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Matrix metalloproteinases 2 and 9 immunoexpression in prostate carcinoma at the positive margin of radical prostatectomy specimens.

Oguić R, Mozetič V, Cini Tešar E, Fučkar Čupić D, Mustać E, Dorđević G - Patholog Res Int (2014)

Bottom Line: Tissue microarrays of 120 archival prostate carcinoma samples were immunohistochemically evaluated for MMP-2 and MMP-9 expression and compared with clinicopathological parameters.In the group of patients with negative margins, MMP-9 expression above the cut-off value was significantly associated with recurrence (P = 0.0065).Multivariate analysis indicated that MMP-9 is a good predictor of biochemical recurrence (odds ratio = 10.29; P = 0.0052).

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Clinical Hospital Centre Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.

ABSTRACT
The aim of this study was to evaluate the expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) in prostate cancer in the main tumor mass and tumor cells at the positive margin as well as the influence of these biomarkers on the biochemical recurrence of the disease in prostatectomy patients. Tissue microarrays of 120 archival prostate carcinoma samples were immunohistochemically evaluated for MMP-2 and MMP-9 expression and compared with clinicopathological parameters. Tumors with positive surgical margins showed significantly higher overall expression of MMP-9 versus tumors with negative resection margins (P = 0.0121). MMP-9 expression was significantly elevated in tumors from patients who had biochemical recurrence (P = 0.0207). In the group of patients with negative margins, MMP-9 expression above the cut-off value was significantly associated with recurrence (P = 0.0065). Multivariate analysis indicated that MMP-9 is a good predictor of biochemical recurrence (odds ratio = 10.29; P = 0.0052). Expression of MMP-2 in tumor cells was significantly higher at the positive margins than in the main tumor mass (P = 0.0301). The present results highlight the potential value of MMP-2 and MMP-9 expression for predicting the behavior of prostate tumors after prostatectomy with both positive and negative surgical margins.

No MeSH data available.


Related in: MedlinePlus

Biochemical recurrence with respect to molecular biomarkers in patients with tumors with negative surgical margins.
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Related In: Results  -  Collection


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fig2: Biochemical recurrence with respect to molecular biomarkers in patients with tumors with negative surgical margins.

Mentions: We analyzed the biochemical recurrence of the disease in relation to MMP expression in the group of patients with negative surgical margins that did not receive any therapy after prostatectomy that could have affected the outcome. MMP-9 expression was significantly elevated in tumors from patients who experienced biochemical recurrence (P = 0.0207). MMP-2 expression in tumors tended to be increased in patients with biochemical recurrence (P = 0.0770; Figure 2).


Matrix metalloproteinases 2 and 9 immunoexpression in prostate carcinoma at the positive margin of radical prostatectomy specimens.

Oguić R, Mozetič V, Cini Tešar E, Fučkar Čupić D, Mustać E, Dorđević G - Patholog Res Int (2014)

Biochemical recurrence with respect to molecular biomarkers in patients with tumors with negative surgical margins.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4109076&req=5

fig2: Biochemical recurrence with respect to molecular biomarkers in patients with tumors with negative surgical margins.
Mentions: We analyzed the biochemical recurrence of the disease in relation to MMP expression in the group of patients with negative surgical margins that did not receive any therapy after prostatectomy that could have affected the outcome. MMP-9 expression was significantly elevated in tumors from patients who experienced biochemical recurrence (P = 0.0207). MMP-2 expression in tumors tended to be increased in patients with biochemical recurrence (P = 0.0770; Figure 2).

Bottom Line: Tissue microarrays of 120 archival prostate carcinoma samples were immunohistochemically evaluated for MMP-2 and MMP-9 expression and compared with clinicopathological parameters.In the group of patients with negative margins, MMP-9 expression above the cut-off value was significantly associated with recurrence (P = 0.0065).Multivariate analysis indicated that MMP-9 is a good predictor of biochemical recurrence (odds ratio = 10.29; P = 0.0052).

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Clinical Hospital Centre Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.

ABSTRACT
The aim of this study was to evaluate the expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) in prostate cancer in the main tumor mass and tumor cells at the positive margin as well as the influence of these biomarkers on the biochemical recurrence of the disease in prostatectomy patients. Tissue microarrays of 120 archival prostate carcinoma samples were immunohistochemically evaluated for MMP-2 and MMP-9 expression and compared with clinicopathological parameters. Tumors with positive surgical margins showed significantly higher overall expression of MMP-9 versus tumors with negative resection margins (P = 0.0121). MMP-9 expression was significantly elevated in tumors from patients who had biochemical recurrence (P = 0.0207). In the group of patients with negative margins, MMP-9 expression above the cut-off value was significantly associated with recurrence (P = 0.0065). Multivariate analysis indicated that MMP-9 is a good predictor of biochemical recurrence (odds ratio = 10.29; P = 0.0052). Expression of MMP-2 in tumor cells was significantly higher at the positive margins than in the main tumor mass (P = 0.0301). The present results highlight the potential value of MMP-2 and MMP-9 expression for predicting the behavior of prostate tumors after prostatectomy with both positive and negative surgical margins.

No MeSH data available.


Related in: MedlinePlus