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The microRNAs as prognostic biomarkers for survival in esophageal cancer: a meta-analysis.

Fu W, Pang L, Chen Y, Yang L, Zhu J, Wei Y - ScientificWorldJournal (2014)

Bottom Line: In all, thirty-nine miRNAs associated with prognosis were reported in these studies.The pooled HR of higher miR-21 expression compared with lower miR-21 expression in ESCC was 1.84 (95% CI: 1.41-2.40, P < 0.001), which could significantly predict poorer OS in ESCC.Our results support that miR-21 and miR-375 have a prognostic role in ESCC and may be useful therapeutic targets for the treatment of ESCC and meticulous follow-up for early detection of recurrence.

View Article: PubMed Central - PubMed

Affiliation: Medical College of Shihezi University, Shihezi, Xinjiang 832000, China ; Department of Thoracic and Cardiovascular Surgery, Hospital of Xinjiang Production and Construction Corps, Urumchi, Xinjiang 830002, China.

ABSTRACT

Objectives: We performed this meta-analysis to summarize all the results from available studies, aiming delineating the prognostic role of miRNA in esophageal cancer.

Design and methods: We searched the electronic databases PubMed, EMBASE, and ISI Web of Science without time restrictions for the correlative literature to aggregate the survival results. Relevant data were extracted from studies investigating the relationship between miRNAs expression and survival in esophageal cancer patients. Pooled hazard ratios of miR-21 and miR-375 for OS in ESCC were calculated.

Results: A total of 25 studies involving 2,258 subjects analyzed the relationship between miRNA and prognosis of EC. In all, thirty-nine miRNAs associated with prognosis were reported in these studies. The pooled HR of higher miR-21 expression compared with lower miR-21 expression in ESCC was 1.84 (95% CI: 1.41-2.40, P < 0.001), which could significantly predict poorer OS in ESCC. Besides, higher miR-375 was also a significant predictor for OS in ESCC, with a pooled HR of 0.55 (95% CI: 0.42-0.72, P < 0.001).

Conclusions: Our results support that miR-21 and miR-375 have a prognostic role in ESCC and may be useful therapeutic targets for the treatment of ESCC and meticulous follow-up for early detection of recurrence.

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Related in: MedlinePlus

(a) Forest plots of studies evaluating hazard ratios (HRs) of high miR375 expression as compared to low expression. (b) Funnel plots of publication bias for meta-analysis of miR-375. (c) Sensitivity analysis for meta-analysis of miR-375.
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fig2: (a) Forest plots of studies evaluating hazard ratios (HRs) of high miR375 expression as compared to low expression. (b) Funnel plots of publication bias for meta-analysis of miR-375. (c) Sensitivity analysis for meta-analysis of miR-375.

Mentions: For studies evaluating OS in ESCC, no significant heterogeneity have been found (for miR-21: I2 = 0.00%, P = 0.26; miR-375: I2 = 0.00%, P = 0.13), so that the fixed effects were applied to calculate the pooled HR (pooled HR = 1.84, 95% CI 1.41–2.40 P < 0.001 for miR-21, Figure 1; and 0.55, 95% CI: 0.42–0.72, P < 0.001 for miR-375, Figure 2). Publication bias of the included studies was evaluated by Begg's plots and Egger's test. No significant publication biases were found in the results of Begg's plots of miR-21 and miR-375. Egger test reached similar conclusions. Pooled HR and 95% CI were not calculated for miR-145 because of different EC histology and types of survival analysis.


The microRNAs as prognostic biomarkers for survival in esophageal cancer: a meta-analysis.

Fu W, Pang L, Chen Y, Yang L, Zhu J, Wei Y - ScientificWorldJournal (2014)

(a) Forest plots of studies evaluating hazard ratios (HRs) of high miR375 expression as compared to low expression. (b) Funnel plots of publication bias for meta-analysis of miR-375. (c) Sensitivity analysis for meta-analysis of miR-375.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4109072&req=5

fig2: (a) Forest plots of studies evaluating hazard ratios (HRs) of high miR375 expression as compared to low expression. (b) Funnel plots of publication bias for meta-analysis of miR-375. (c) Sensitivity analysis for meta-analysis of miR-375.
Mentions: For studies evaluating OS in ESCC, no significant heterogeneity have been found (for miR-21: I2 = 0.00%, P = 0.26; miR-375: I2 = 0.00%, P = 0.13), so that the fixed effects were applied to calculate the pooled HR (pooled HR = 1.84, 95% CI 1.41–2.40 P < 0.001 for miR-21, Figure 1; and 0.55, 95% CI: 0.42–0.72, P < 0.001 for miR-375, Figure 2). Publication bias of the included studies was evaluated by Begg's plots and Egger's test. No significant publication biases were found in the results of Begg's plots of miR-21 and miR-375. Egger test reached similar conclusions. Pooled HR and 95% CI were not calculated for miR-145 because of different EC histology and types of survival analysis.

Bottom Line: In all, thirty-nine miRNAs associated with prognosis were reported in these studies.The pooled HR of higher miR-21 expression compared with lower miR-21 expression in ESCC was 1.84 (95% CI: 1.41-2.40, P < 0.001), which could significantly predict poorer OS in ESCC.Our results support that miR-21 and miR-375 have a prognostic role in ESCC and may be useful therapeutic targets for the treatment of ESCC and meticulous follow-up for early detection of recurrence.

View Article: PubMed Central - PubMed

Affiliation: Medical College of Shihezi University, Shihezi, Xinjiang 832000, China ; Department of Thoracic and Cardiovascular Surgery, Hospital of Xinjiang Production and Construction Corps, Urumchi, Xinjiang 830002, China.

ABSTRACT

Objectives: We performed this meta-analysis to summarize all the results from available studies, aiming delineating the prognostic role of miRNA in esophageal cancer.

Design and methods: We searched the electronic databases PubMed, EMBASE, and ISI Web of Science without time restrictions for the correlative literature to aggregate the survival results. Relevant data were extracted from studies investigating the relationship between miRNAs expression and survival in esophageal cancer patients. Pooled hazard ratios of miR-21 and miR-375 for OS in ESCC were calculated.

Results: A total of 25 studies involving 2,258 subjects analyzed the relationship between miRNA and prognosis of EC. In all, thirty-nine miRNAs associated with prognosis were reported in these studies. The pooled HR of higher miR-21 expression compared with lower miR-21 expression in ESCC was 1.84 (95% CI: 1.41-2.40, P < 0.001), which could significantly predict poorer OS in ESCC. Besides, higher miR-375 was also a significant predictor for OS in ESCC, with a pooled HR of 0.55 (95% CI: 0.42-0.72, P < 0.001).

Conclusions: Our results support that miR-21 and miR-375 have a prognostic role in ESCC and may be useful therapeutic targets for the treatment of ESCC and meticulous follow-up for early detection of recurrence.

Show MeSH
Related in: MedlinePlus