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Kinetics of orthostatic blood pressure in primary hypertension.

Milouk FZ, El Bakkali M, Coghlan L, Lachhab A, Aboudrar S, Benjelloun H - Int Cardiovasc Res J (2014)

Bottom Line: Orthostatic systolic BP (Ortho SBP) was recorded for 10 minutes at the rhythm of 3 measurements per minute and was compared to the values of supine systolic preorthostatic (Preortho SBP).Hypertensives with very similar supine SBP behavior could exhibit widely different Ortho SBP.Thus, careful and effective treatment of hypertensives requires careful consideration and assessment of orthostatic BP.

View Article: PubMed Central - PubMed

Affiliation: Unit of Cardiology A, Ibn Sina University Hospital, Rabat 10000, Morocco.

ABSTRACT

Background: Primary Hypertension (HT) is the most prevalent cardiovascular disorder worldwide and is accompanied by significant morbidity and mortality.

Objectives: The present study aimed to investigate the kinetics of orthostatic Blood Pressure (BP) in primary hypertensive patients during the change from supine position to standing position as well as during the standing position using the Orthostatic Test (OT).

Patients and methods: This prospective study included a group of 107 primary hypertensive patients (mean age: 55.82 ± 11.35 years, ranging from 39 to 80 years). Orthostatic systolic BP (Ortho SBP) was recorded for 10 minutes at the rhythm of 3 measurements per minute and was compared to the values of supine systolic preorthostatic (Preortho SBP). According to the changes in Ortho SBP, three subgroups of primary hypertensive patients were selected as follows: Subgroup A: Ortho SBP was higher than mean Preortho SBP by 10 mmHg or more. Subgroup B: Ortho SBP was lower than mean Preortho SBP by 20 mmHg or more. Subgroup C: -20 mmHg < (Ortho SBP - Preortho SBP) < + 10 mmHg. The kinetics of each group was then recorded.

Results: In this study, the prevalence of subgroups A, B, and C was 27.1%, 15.9%, and 57.0%, respectively. In subgroup A, the adrenergic peripheral sympathetic alpha response was 20% during the OT.

Conclusions: Hypertensives with very similar supine SBP behavior could exhibit widely different Ortho SBP. Thus, careful and effective treatment of hypertensives requires careful consideration and assessment of orthostatic BP.

No MeSH data available.


Related in: MedlinePlus

Representative Curve of the Kinetics of the Mean SBP in the Hypertensive Patients of Subgroup B during Orthostatic Test (**: P < 0.05)
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fig11912: Representative Curve of the Kinetics of the Mean SBP in the Hypertensive Patients of Subgroup B during Orthostatic Test (**: P < 0.05)

Mentions: In subgroup B, 17 hypertensive patients had OH (15.9% of the total population), 59% of whom (10/17) were female. The mean Preortho SBP was 163.4 ± 7.2 mmHg ranging from 160 to 167 mmHg. In addition, the mean Ortho SBP was 137.5 ± 11.2 mmHg ranging from 128 to 143 mmHg. In this subgroup, in comparison to Preortho SBP, the mean Ortho SBP decreased in the first minute of OT (-20.3 mmHg) and continued to decrease throughout the whole OT. The change was -36.2 mmHg in the 5th minute and -38.4 mmHg in the 10th minute. OH was maintained throughout the test (Figure 2).


Kinetics of orthostatic blood pressure in primary hypertension.

Milouk FZ, El Bakkali M, Coghlan L, Lachhab A, Aboudrar S, Benjelloun H - Int Cardiovasc Res J (2014)

Representative Curve of the Kinetics of the Mean SBP in the Hypertensive Patients of Subgroup B during Orthostatic Test (**: P < 0.05)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109041&req=5

fig11912: Representative Curve of the Kinetics of the Mean SBP in the Hypertensive Patients of Subgroup B during Orthostatic Test (**: P < 0.05)
Mentions: In subgroup B, 17 hypertensive patients had OH (15.9% of the total population), 59% of whom (10/17) were female. The mean Preortho SBP was 163.4 ± 7.2 mmHg ranging from 160 to 167 mmHg. In addition, the mean Ortho SBP was 137.5 ± 11.2 mmHg ranging from 128 to 143 mmHg. In this subgroup, in comparison to Preortho SBP, the mean Ortho SBP decreased in the first minute of OT (-20.3 mmHg) and continued to decrease throughout the whole OT. The change was -36.2 mmHg in the 5th minute and -38.4 mmHg in the 10th minute. OH was maintained throughout the test (Figure 2).

Bottom Line: Orthostatic systolic BP (Ortho SBP) was recorded for 10 minutes at the rhythm of 3 measurements per minute and was compared to the values of supine systolic preorthostatic (Preortho SBP).Hypertensives with very similar supine SBP behavior could exhibit widely different Ortho SBP.Thus, careful and effective treatment of hypertensives requires careful consideration and assessment of orthostatic BP.

View Article: PubMed Central - PubMed

Affiliation: Unit of Cardiology A, Ibn Sina University Hospital, Rabat 10000, Morocco.

ABSTRACT

Background: Primary Hypertension (HT) is the most prevalent cardiovascular disorder worldwide and is accompanied by significant morbidity and mortality.

Objectives: The present study aimed to investigate the kinetics of orthostatic Blood Pressure (BP) in primary hypertensive patients during the change from supine position to standing position as well as during the standing position using the Orthostatic Test (OT).

Patients and methods: This prospective study included a group of 107 primary hypertensive patients (mean age: 55.82 ± 11.35 years, ranging from 39 to 80 years). Orthostatic systolic BP (Ortho SBP) was recorded for 10 minutes at the rhythm of 3 measurements per minute and was compared to the values of supine systolic preorthostatic (Preortho SBP). According to the changes in Ortho SBP, three subgroups of primary hypertensive patients were selected as follows: Subgroup A: Ortho SBP was higher than mean Preortho SBP by 10 mmHg or more. Subgroup B: Ortho SBP was lower than mean Preortho SBP by 20 mmHg or more. Subgroup C: -20 mmHg < (Ortho SBP - Preortho SBP) < + 10 mmHg. The kinetics of each group was then recorded.

Results: In this study, the prevalence of subgroups A, B, and C was 27.1%, 15.9%, and 57.0%, respectively. In subgroup A, the adrenergic peripheral sympathetic alpha response was 20% during the OT.

Conclusions: Hypertensives with very similar supine SBP behavior could exhibit widely different Ortho SBP. Thus, careful and effective treatment of hypertensives requires careful consideration and assessment of orthostatic BP.

No MeSH data available.


Related in: MedlinePlus