Limits...
New oral anticoagulants in acute coronary syndrome: is there any advantage over existing treatments?

Messori A, Fadda V, Gatto R, Maratea D, Trippoli S - Int Cardiovasc Res J (2014)

Bottom Line: According to these margins, triple therapy based on any NOAC proved to be superior to dual therapy alone, but at the same time demonstrated its equivalence with dual therapy.The results for apixaban-based triple therapy were inconclusive (not superior, not not-inferior, not equivalent and, of course, not inferior to the controls).Those for rivaroxaban-based triple therapy showed that this combination treatment was superior to dual therapy alone and failed to meet the criterion of equivalence.

View Article: PubMed Central - PubMed

Affiliation: HTA Unit, ESTAV Toscana Centro, Regional Health Service, 50100 Firenze, Italy.

ABSTRACT

Background: After an acute coronary syndrome, dual antiplatelet therapy with clopidogrel plus aspirin is still a standard of care, but several new approaches have been investigated.

Objectives: The present study re-examined the studies published thus far on this topic to evaluate the effectiveness of dual antiplatelet therapy in comparison to some of these new approaches (mainly, ticagrelor + aspirin and dual therapy plus a new oral anticoagulant [NOAC]; i.e., "triple therapy").

Materials and methods: The clinical material was directly derived from that reported in recent meta-analyses. Our re-analysis relied on standard equivalence methods in which interpretation is based on Relative Risks (RRs) along with their 95% Confidence Intervals (CI). The equivalence margins employed in our statistical testing were directly derived from those reported in randomized studies.

Results: The equivalence margins were initially set at RR ranging from 0.775 to 1.29. According to these margins, triple therapy based on any NOAC proved to be superior to dual therapy alone, but at the same time demonstrated its equivalence with dual therapy. The results for apixaban-based triple therapy were inconclusive (not superior, not not-inferior, not equivalent and, of course, not inferior to the controls). Those for rivaroxaban-based triple therapy showed that this combination treatment was superior to dual therapy alone and failed to meet the criterion of equivalence. In the comparison between rivaroxaban-based triple therapy and ticagrelor + aspirin, the RR was 1 and its 95% CI remained within a post-hoc margin of ± 15%.

Conclusions: Even if one considers the most effective NOAC in combination with clopidogrel + ticagrelor, this triple therapy is not more effective than ticagrelor + aspirin. On the other hand, the increased risk of bleeding with triple regimens is well demonstrated. We therefore conclude that these triple regimens did not play any important roles in the patients experiencing an acute coronary syndrome.

No MeSH data available.


Related in: MedlinePlus

Rates of MACE after Acute Coronary Syndrome in the Patients Treated with Different Combinations of NAOCs and/or Antiplatelet AgentsThe equivalence test is based on the area comprised between the two vertical dashed lines reflecting the pre-determined equivalence margins (from 0.775 to around 1.29). Each horizontal bar indicates two-sided 95% CI for the RR (solid square). The criterion for demonstrating equivalence is when both extremes of the 95% CI remain within the two vertical lines. Comparisons (top to bottom): 1) triple therapy with clopidogrel + aspirin + any NOAC vs. dual therapy; 2) triple therapy with apixaban + clopidogrel + aspirin vs. dual therapy (APPRAISE-2 trial); 3) triple therapy with rivaroxaban + clopidogrel + aspirin vs. dual therapy (ATLAS-2 trial); 4) triple therapy with rivaroxaban + clopidogrel + aspirin vs. ticagrelor + aspirin. All the effectiveness data were derived from Olsgren’s meta-analysis (4) with the exception of the fourth comparison the data of which were obtained from Gatto et al. (5).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4109037&req=5

fig11922: Rates of MACE after Acute Coronary Syndrome in the Patients Treated with Different Combinations of NAOCs and/or Antiplatelet AgentsThe equivalence test is based on the area comprised between the two vertical dashed lines reflecting the pre-determined equivalence margins (from 0.775 to around 1.29). Each horizontal bar indicates two-sided 95% CI for the RR (solid square). The criterion for demonstrating equivalence is when both extremes of the 95% CI remain within the two vertical lines. Comparisons (top to bottom): 1) triple therapy with clopidogrel + aspirin + any NOAC vs. dual therapy; 2) triple therapy with apixaban + clopidogrel + aspirin vs. dual therapy (APPRAISE-2 trial); 3) triple therapy with rivaroxaban + clopidogrel + aspirin vs. dual therapy (ATLAS-2 trial); 4) triple therapy with rivaroxaban + clopidogrel + aspirin vs. ticagrelor + aspirin. All the effectiveness data were derived from Olsgren’s meta-analysis (4) with the exception of the fourth comparison the data of which were obtained from Gatto et al. (5).

Mentions: The present study results have been summarized in Figure 1. Considering the pooled RR for all NOACs, triple therapy proved to be superior to dual therapy alone, but at the same time demonstrated its equivalence with dual therapy (according to the equivalence margin of around ± 22.5%). This contradiction can, in general, have two different explanations: too wide equivalence margins or very small magnitude of the benefit despite its statistical significance. In this case, the first explanation is preferable (6).


New oral anticoagulants in acute coronary syndrome: is there any advantage over existing treatments?

Messori A, Fadda V, Gatto R, Maratea D, Trippoli S - Int Cardiovasc Res J (2014)

Rates of MACE after Acute Coronary Syndrome in the Patients Treated with Different Combinations of NAOCs and/or Antiplatelet AgentsThe equivalence test is based on the area comprised between the two vertical dashed lines reflecting the pre-determined equivalence margins (from 0.775 to around 1.29). Each horizontal bar indicates two-sided 95% CI for the RR (solid square). The criterion for demonstrating equivalence is when both extremes of the 95% CI remain within the two vertical lines. Comparisons (top to bottom): 1) triple therapy with clopidogrel + aspirin + any NOAC vs. dual therapy; 2) triple therapy with apixaban + clopidogrel + aspirin vs. dual therapy (APPRAISE-2 trial); 3) triple therapy with rivaroxaban + clopidogrel + aspirin vs. dual therapy (ATLAS-2 trial); 4) triple therapy with rivaroxaban + clopidogrel + aspirin vs. ticagrelor + aspirin. All the effectiveness data were derived from Olsgren’s meta-analysis (4) with the exception of the fourth comparison the data of which were obtained from Gatto et al. (5).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109037&req=5

fig11922: Rates of MACE after Acute Coronary Syndrome in the Patients Treated with Different Combinations of NAOCs and/or Antiplatelet AgentsThe equivalence test is based on the area comprised between the two vertical dashed lines reflecting the pre-determined equivalence margins (from 0.775 to around 1.29). Each horizontal bar indicates two-sided 95% CI for the RR (solid square). The criterion for demonstrating equivalence is when both extremes of the 95% CI remain within the two vertical lines. Comparisons (top to bottom): 1) triple therapy with clopidogrel + aspirin + any NOAC vs. dual therapy; 2) triple therapy with apixaban + clopidogrel + aspirin vs. dual therapy (APPRAISE-2 trial); 3) triple therapy with rivaroxaban + clopidogrel + aspirin vs. dual therapy (ATLAS-2 trial); 4) triple therapy with rivaroxaban + clopidogrel + aspirin vs. ticagrelor + aspirin. All the effectiveness data were derived from Olsgren’s meta-analysis (4) with the exception of the fourth comparison the data of which were obtained from Gatto et al. (5).
Mentions: The present study results have been summarized in Figure 1. Considering the pooled RR for all NOACs, triple therapy proved to be superior to dual therapy alone, but at the same time demonstrated its equivalence with dual therapy (according to the equivalence margin of around ± 22.5%). This contradiction can, in general, have two different explanations: too wide equivalence margins or very small magnitude of the benefit despite its statistical significance. In this case, the first explanation is preferable (6).

Bottom Line: According to these margins, triple therapy based on any NOAC proved to be superior to dual therapy alone, but at the same time demonstrated its equivalence with dual therapy.The results for apixaban-based triple therapy were inconclusive (not superior, not not-inferior, not equivalent and, of course, not inferior to the controls).Those for rivaroxaban-based triple therapy showed that this combination treatment was superior to dual therapy alone and failed to meet the criterion of equivalence.

View Article: PubMed Central - PubMed

Affiliation: HTA Unit, ESTAV Toscana Centro, Regional Health Service, 50100 Firenze, Italy.

ABSTRACT

Background: After an acute coronary syndrome, dual antiplatelet therapy with clopidogrel plus aspirin is still a standard of care, but several new approaches have been investigated.

Objectives: The present study re-examined the studies published thus far on this topic to evaluate the effectiveness of dual antiplatelet therapy in comparison to some of these new approaches (mainly, ticagrelor + aspirin and dual therapy plus a new oral anticoagulant [NOAC]; i.e., "triple therapy").

Materials and methods: The clinical material was directly derived from that reported in recent meta-analyses. Our re-analysis relied on standard equivalence methods in which interpretation is based on Relative Risks (RRs) along with their 95% Confidence Intervals (CI). The equivalence margins employed in our statistical testing were directly derived from those reported in randomized studies.

Results: The equivalence margins were initially set at RR ranging from 0.775 to 1.29. According to these margins, triple therapy based on any NOAC proved to be superior to dual therapy alone, but at the same time demonstrated its equivalence with dual therapy. The results for apixaban-based triple therapy were inconclusive (not superior, not not-inferior, not equivalent and, of course, not inferior to the controls). Those for rivaroxaban-based triple therapy showed that this combination treatment was superior to dual therapy alone and failed to meet the criterion of equivalence. In the comparison between rivaroxaban-based triple therapy and ticagrelor + aspirin, the RR was 1 and its 95% CI remained within a post-hoc margin of ± 15%.

Conclusions: Even if one considers the most effective NOAC in combination with clopidogrel + ticagrelor, this triple therapy is not more effective than ticagrelor + aspirin. On the other hand, the increased risk of bleeding with triple regimens is well demonstrated. We therefore conclude that these triple regimens did not play any important roles in the patients experiencing an acute coronary syndrome.

No MeSH data available.


Related in: MedlinePlus