Limits...
Circulating endothelial-derived apoptotic microparticles in the patients with ischemic symptomatic chronic heart failure: relevance of pro-inflammatory activation and outcomes.

Berezin AE, Kremzer AA, Samura TA, Martovitskaya YV - Int Cardiovasc Res J (2014)

Bottom Line: Besides, P < 0.05 was considered as statistically significant.During a median follow-up of 2.18 years, 21 participants died and 106 subjects were hospitalized repetitively.The number of circulating EPMs independently predicted all-cause mortality (OR = 1.58; 95% CI = 1.20 - 1.88; P = 0.001), CHF-related death (OR = 1.22; 95% CI: 1.12 - 1.36; P < 0.001), and CHF-related re-hospitalization (OR = 1.20; 95% CI: 1.11 - 1.32; P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: State Medical University, Internal Medicine Department, Zaporozhye, Ukraine.

ABSTRACT

Background: Endothelial-derived apoptotic microparticles (EMPs) play a pivotal role in endothelial dysfunction in hronic Heart Failure (CHF).

Objectives: The present study aimed to evaluate the association between EMPs and pro-inflammatory biomarkers, clinical status, and outcomes in the patients with ischemic CHF.

Patients and methods: This study was conducted on 154 patients with ischemic symptomatic moderate-to-severe CHF on discharge from hospital. The observation period was up to 3 years. Circulating NT-pro-BNP, TNF-alpha, sFas, and sFas ligand were determined at baseline. Flow cytometry analysis was used for quantifying the number of EMPs. All-cause mortality, CHF-related death, and CHD-re-hospitalization rate were examined. The data were analyzed using descriptive statistics, Receive Operation Characteristic Curve (ROC), and logistic regression analysis. Besides, P < 0.05 was considered as statistically significant.

Results: During a median follow-up of 2.18 years, 21 participants died and 106 subjects were hospitalized repetitively. The results showed a significant difference between the patients with a large number of EMPs (> 0.514 n/mL) and those with a low level of the biomarker (< 0.514 n/mL) regarding their survival. The number of circulating EPMs independently predicted all-cause mortality (OR = 1.58; 95% CI = 1.20 - 1.88; P = 0.001), CHF-related death (OR = 1.22; 95% CI: 1.12 - 1.36; P < 0.001), and CHF-related re-hospitalization (OR = 1.20; 95% CI: 1.11 - 1.32; P < 0.001).

Conclusions: Among the patients with symptoms of CHF, increased number of circulating EMPs was associated with increased 3-year CHF-related death, all-cause mortality, and risk of recurrent hospitalization due to CHF.

No MeSH data available.


Related in: MedlinePlus

Reliability of the Model Included EMPs Number for Cumulative Survival in Study Patient Population; Results of the Receive Operation Characteristic Curve (ROC) Analysis. The Figure Shows the Ratio of Sensitivity and Specificity for Optimal Predict Number of EMPs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4109036&req=5

fig11944: Reliability of the Model Included EMPs Number for Cumulative Survival in Study Patient Population; Results of the Receive Operation Characteristic Curve (ROC) Analysis. The Figure Shows the Ratio of Sensitivity and Specificity for Optimal Predict Number of EMPs.

Mentions: The optimum cut-off point for EMPs number in circulation was determined by the relative importance of the sensitivity and specificity of the test. ROC analysis showed that the cut-off point of EMPs number for cumulative survival function was 0.514 n/mL (Figure 2). Besides, the area under cure was 0.913 (Std. error = 0.025; 95% CI, 0.863 - 0.962) and the sensitivity and specificity of the test were 89.6% and 69.7%, respectively. The model was robust for all the occasions and provided significant results using the optimal cut-off point of EMPs (Table 4). The results revealed a significant difference between the patients with a large number of EMPs (> 0.514 n/mL) and those with a low level of the biomarker (< 0.514 n/mL) regarding their survival. The divergence of survival curves reached statistical significance in the 50th week of the observation period (P < 0.001) (Figure 3).


Circulating endothelial-derived apoptotic microparticles in the patients with ischemic symptomatic chronic heart failure: relevance of pro-inflammatory activation and outcomes.

Berezin AE, Kremzer AA, Samura TA, Martovitskaya YV - Int Cardiovasc Res J (2014)

Reliability of the Model Included EMPs Number for Cumulative Survival in Study Patient Population; Results of the Receive Operation Characteristic Curve (ROC) Analysis. The Figure Shows the Ratio of Sensitivity and Specificity for Optimal Predict Number of EMPs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109036&req=5

fig11944: Reliability of the Model Included EMPs Number for Cumulative Survival in Study Patient Population; Results of the Receive Operation Characteristic Curve (ROC) Analysis. The Figure Shows the Ratio of Sensitivity and Specificity for Optimal Predict Number of EMPs.
Mentions: The optimum cut-off point for EMPs number in circulation was determined by the relative importance of the sensitivity and specificity of the test. ROC analysis showed that the cut-off point of EMPs number for cumulative survival function was 0.514 n/mL (Figure 2). Besides, the area under cure was 0.913 (Std. error = 0.025; 95% CI, 0.863 - 0.962) and the sensitivity and specificity of the test were 89.6% and 69.7%, respectively. The model was robust for all the occasions and provided significant results using the optimal cut-off point of EMPs (Table 4). The results revealed a significant difference between the patients with a large number of EMPs (> 0.514 n/mL) and those with a low level of the biomarker (< 0.514 n/mL) regarding their survival. The divergence of survival curves reached statistical significance in the 50th week of the observation period (P < 0.001) (Figure 3).

Bottom Line: Besides, P < 0.05 was considered as statistically significant.During a median follow-up of 2.18 years, 21 participants died and 106 subjects were hospitalized repetitively.The number of circulating EPMs independently predicted all-cause mortality (OR = 1.58; 95% CI = 1.20 - 1.88; P = 0.001), CHF-related death (OR = 1.22; 95% CI: 1.12 - 1.36; P < 0.001), and CHF-related re-hospitalization (OR = 1.20; 95% CI: 1.11 - 1.32; P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: State Medical University, Internal Medicine Department, Zaporozhye, Ukraine.

ABSTRACT

Background: Endothelial-derived apoptotic microparticles (EMPs) play a pivotal role in endothelial dysfunction in hronic Heart Failure (CHF).

Objectives: The present study aimed to evaluate the association between EMPs and pro-inflammatory biomarkers, clinical status, and outcomes in the patients with ischemic CHF.

Patients and methods: This study was conducted on 154 patients with ischemic symptomatic moderate-to-severe CHF on discharge from hospital. The observation period was up to 3 years. Circulating NT-pro-BNP, TNF-alpha, sFas, and sFas ligand were determined at baseline. Flow cytometry analysis was used for quantifying the number of EMPs. All-cause mortality, CHF-related death, and CHD-re-hospitalization rate were examined. The data were analyzed using descriptive statistics, Receive Operation Characteristic Curve (ROC), and logistic regression analysis. Besides, P < 0.05 was considered as statistically significant.

Results: During a median follow-up of 2.18 years, 21 participants died and 106 subjects were hospitalized repetitively. The results showed a significant difference between the patients with a large number of EMPs (> 0.514 n/mL) and those with a low level of the biomarker (< 0.514 n/mL) regarding their survival. The number of circulating EPMs independently predicted all-cause mortality (OR = 1.58; 95% CI = 1.20 - 1.88; P = 0.001), CHF-related death (OR = 1.22; 95% CI: 1.12 - 1.36; P < 0.001), and CHF-related re-hospitalization (OR = 1.20; 95% CI: 1.11 - 1.32; P < 0.001).

Conclusions: Among the patients with symptoms of CHF, increased number of circulating EMPs was associated with increased 3-year CHF-related death, all-cause mortality, and risk of recurrent hospitalization due to CHF.

No MeSH data available.


Related in: MedlinePlus