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The influence of different cellular environments on PET radioligand binding: an application to D2/3-dopamine receptor imaging.

Quelch DR, Withey SL, Nutt DJ, Tyacke RJ, Parker CA - Neuropharmacology (2014)

Bottom Line: Extension of in vivo competition imaging to other receptor systems has been relatively unsuccessful.These studies suggest that sensitivity to endogenous dopamine release in vivo is related to a decrease in affinity in the endosomal environment compared with those found at the cell surface.This pharmacological approach is fully translatable to other receptor systems.

View Article: PubMed Central - PubMed

Affiliation: Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, UK. Electronic address: d.quelch09@imperial.ac.uk.

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The influence of different cellular environments on PET radioligand binding: an application to D2/3-dopamine receptor imaging.

Quelch DR, Withey SL, Nutt DJ, Tyacke RJ, Parker CA - Neuropharmacology (2014)

© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109028&req=5

Bottom Line: Extension of in vivo competition imaging to other receptor systems has been relatively unsuccessful.These studies suggest that sensitivity to endogenous dopamine release in vivo is related to a decrease in affinity in the endosomal environment compared with those found at the cell surface.This pharmacological approach is fully translatable to other receptor systems.

View Article: PubMed Central - PubMed

Affiliation: Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, UK. Electronic address: d.quelch09@imperial.ac.uk.

Show MeSH