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Inherent insulin sensitivity is a major determinant of multimeric adiponectin responsiveness to short-term weight loss in extreme obesity.

Mai S, Walker GE, Brunani A, Guzzaloni G, Grossi G, Oldani A, Aimaretti G, Scacchi M, Marzullo P - Sci Rep (2014)

Bottom Line: In obese patients, short-term weight loss did not change total adiponectin levels and insulin resistance, while the distribution pattern of adiponectin oligomers changed due to significant increment of HMW-A (p < 0.01) and reduction of MMW-A (p < 0.05).By multivariate analysis, final HMW-A levels were significantly related to baseline ISIOGTT and final body weight (adjusted R(2) = 0.41).Especially, we documented that HMW-A is promptly responsive to short-term weight loss prior to changes in insulin resistance, by a magnitude that is proportioned to whole body insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Metabolic Research, Ospedale S. Giuseppe, I.R.C.S.S. Istituto Auxologico Italiano, Strada Cadorna 90, 28921, Piancavallo-Verbania.

ABSTRACT
High molecular weight (HMW-A) adiponectin levels mirror alterations in glucose homeostasis better than medium (MMW-A) and low molecular weight (LMW-A) components. In 25 patients with wide-range extreme obesity (BMI 40-77 kg/m(2)), we aimed to explore if improvements of multimeric adiponectin following 4-wk weight loss reflect baseline OGTT-derived insulin sensitivity (ISIOGTT) and disposition index (DIOGTT). Compared to 40 lean controls, adiponectin oligomers were lower in extreme obesity (p < 0.001) and, within this group, HMW-A levels were higher in insulin-sensitive (p < 0.05) than -resistant patients. In obese patients, short-term weight loss did not change total adiponectin levels and insulin resistance, while the distribution pattern of adiponectin oligomers changed due to significant increment of HMW-A (p < 0.01) and reduction of MMW-A (p < 0.05). By multivariate analysis, final HMW-A levels were significantly related to baseline ISIOGTT and final body weight (adjusted R(2) = 0.41). Our data suggest that HMW adiponectin may reflect baseline insulin sensitivity appropriately in the context of extreme obesity. Especially, we documented that HMW-A is promptly responsive to short-term weight loss prior to changes in insulin resistance, by a magnitude that is proportioned to whole body insulin sensitivity. This may suggest an insulin sensitivity-dependent control operated by HMW-A on metabolic dynamics of patients with extreme obesity.

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Bivariate correlation between the Matsuda Index (ISIOGTT) and baseline (Panel a) and final (Panel b) HMW adiponectin levels in the obese population.Coefficients are discussed in the Results section.
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f1: Bivariate correlation between the Matsuda Index (ISIOGTT) and baseline (Panel a) and final (Panel b) HMW adiponectin levels in the obese population.Coefficients are discussed in the Results section.

Mentions: In the obese population, simple regression analyses at baseline failed to provide associations between adiponectin components and measures of adiposity, such as BMI, waist circumference and percent fat mass, yet values of HMW-to-total adiponectin ratio were negatively related to waist (r = −0.51, p < 0.01). Baseline HMW adiponectin levels paralleled values of ISIOGTT (r = 0.43, p < 0.05; Fig. 1a) and DIOGTT (r = 0.42; p < 0.05), while LMW adiponectin levels were associated to HOMA-IR (r = −0.43, p < 0.05). Also negative was the association between total adiponectin and fasting insulin (r = −0.51, p < 0.01), PAUC (r = −0.45, p < 0.05) and GAUC (r = −43, p < 005).


Inherent insulin sensitivity is a major determinant of multimeric adiponectin responsiveness to short-term weight loss in extreme obesity.

Mai S, Walker GE, Brunani A, Guzzaloni G, Grossi G, Oldani A, Aimaretti G, Scacchi M, Marzullo P - Sci Rep (2014)

Bivariate correlation between the Matsuda Index (ISIOGTT) and baseline (Panel a) and final (Panel b) HMW adiponectin levels in the obese population.Coefficients are discussed in the Results section.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4109026&req=5

f1: Bivariate correlation between the Matsuda Index (ISIOGTT) and baseline (Panel a) and final (Panel b) HMW adiponectin levels in the obese population.Coefficients are discussed in the Results section.
Mentions: In the obese population, simple regression analyses at baseline failed to provide associations between adiponectin components and measures of adiposity, such as BMI, waist circumference and percent fat mass, yet values of HMW-to-total adiponectin ratio were negatively related to waist (r = −0.51, p < 0.01). Baseline HMW adiponectin levels paralleled values of ISIOGTT (r = 0.43, p < 0.05; Fig. 1a) and DIOGTT (r = 0.42; p < 0.05), while LMW adiponectin levels were associated to HOMA-IR (r = −0.43, p < 0.05). Also negative was the association between total adiponectin and fasting insulin (r = −0.51, p < 0.01), PAUC (r = −0.45, p < 0.05) and GAUC (r = −43, p < 005).

Bottom Line: In obese patients, short-term weight loss did not change total adiponectin levels and insulin resistance, while the distribution pattern of adiponectin oligomers changed due to significant increment of HMW-A (p < 0.01) and reduction of MMW-A (p < 0.05).By multivariate analysis, final HMW-A levels were significantly related to baseline ISIOGTT and final body weight (adjusted R(2) = 0.41).Especially, we documented that HMW-A is promptly responsive to short-term weight loss prior to changes in insulin resistance, by a magnitude that is proportioned to whole body insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Metabolic Research, Ospedale S. Giuseppe, I.R.C.S.S. Istituto Auxologico Italiano, Strada Cadorna 90, 28921, Piancavallo-Verbania.

ABSTRACT
High molecular weight (HMW-A) adiponectin levels mirror alterations in glucose homeostasis better than medium (MMW-A) and low molecular weight (LMW-A) components. In 25 patients with wide-range extreme obesity (BMI 40-77 kg/m(2)), we aimed to explore if improvements of multimeric adiponectin following 4-wk weight loss reflect baseline OGTT-derived insulin sensitivity (ISIOGTT) and disposition index (DIOGTT). Compared to 40 lean controls, adiponectin oligomers were lower in extreme obesity (p < 0.001) and, within this group, HMW-A levels were higher in insulin-sensitive (p < 0.05) than -resistant patients. In obese patients, short-term weight loss did not change total adiponectin levels and insulin resistance, while the distribution pattern of adiponectin oligomers changed due to significant increment of HMW-A (p < 0.01) and reduction of MMW-A (p < 0.05). By multivariate analysis, final HMW-A levels were significantly related to baseline ISIOGTT and final body weight (adjusted R(2) = 0.41). Our data suggest that HMW adiponectin may reflect baseline insulin sensitivity appropriately in the context of extreme obesity. Especially, we documented that HMW-A is promptly responsive to short-term weight loss prior to changes in insulin resistance, by a magnitude that is proportioned to whole body insulin sensitivity. This may suggest an insulin sensitivity-dependent control operated by HMW-A on metabolic dynamics of patients with extreme obesity.

Show MeSH
Related in: MedlinePlus