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Social insecurity in relation to orbitofrontal activity in patients with eating disorders: a near-infrared spectroscopy study.

Katayama H, Kohmura K, Tanaka S, Imaeda M, Kawano N, Noda Y, Nishioka K, Ando M, Aleksic B, Iidaka T, Ozaki N - BMC Psychiatry (2014)

Bottom Line: We hypothesized that frontal activity in patients with ED would be lower than in CTLs and would show different correlations with psychopathological features compared with CTLs.The mean change in oxygenated hemoglobin (oxy-Hb) in bilateral frontal regions during the LFT was significantly smaller in the ED group than in the CTL group.These results suggest that activity of the orbitofrontal cortex is associated with social insecurity and disturbed in patients with ED.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi-ken 466-8550, Japan. tanakas@med.nagoya-u.ac.jp.

ABSTRACT

Background: Functional neuroimaging techniques are widely used to elucidate changes in brain activity, and various questionnaires are used to investigate psychopathological features in patients with eating disorders (ED). It is well known that social skills and interpersonal difficulties are strongly associated with the psychopathology of patients with ED. However, few studies have examined the association between brain activity and social relationships in patients with ED, particularly in patients with extremely low body weight.

Methods: In this study, 22-channel near-infrared spectroscopy was used to quantify regional hemodynamic changes during a letter fluency task (LFT) in 20 female patients with ED with a mean body mass index of 14.0 kg/m(2) and 31 female controls (CTLs). Symptoms were assessed using the Eating Disorder Inventory-2 and Beck Depression Inventory. We hypothesized that frontal activity in patients with ED would be lower than in CTLs and would show different correlations with psychopathological features compared with CTLs.

Results: The LFT performance and score on the social insecurity subscale of the Eating Disorder Inventory-2 were significantly higher in the ED group than in the CTL group. The mean change in oxygenated hemoglobin (oxy-Hb) in bilateral frontal regions during the LFT was significantly smaller in the ED group than in the CTL group. Social insecurity score was positively correlated with the concentration of oxy-Hb in the bilateral orbitofrontal cortex in the ED group but not in the CTL group.

Conclusions: These results suggest that activity of the orbitofrontal cortex is associated with social insecurity and disturbed in patients with ED. Therefore, disturbed orbitofrontal cortex activity may underlie the lack of insight and social isolation that is characteristic of patients with ED.

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Related in: MedlinePlus

Enlarged graphs for channels 17 and 22.
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Figure 4: Enlarged graphs for channels 17 and 22.

Mentions: In both the ED group and the CTL group, the mean change in oxy-Hb concentration during the LFT was significantly correlated with the score on the SI subscale of the EDI-2 before significance levels were corrected by the false discovery rate method (Figures 3 and 4); however, the direction of the relation was opposite in the two groups. In the ED group, the mean change in oxy-Hb concentration during the LFT in channels 12, 16, 17, and 19–22 was positively correlated with SI score (r = 0.47 to 0.70, all p < 0.05), whereas in the CTL group, the mean change in oxy-Hb concentration during the LFT in channels 1, 5, 10, 13, 17, 18, and 22 was negatively correlated with SI score (r = -0.38 to -0.56, all p < 0.05). Additional tables show these findings in more detail (see Additional files 6 and 7).


Social insecurity in relation to orbitofrontal activity in patients with eating disorders: a near-infrared spectroscopy study.

Katayama H, Kohmura K, Tanaka S, Imaeda M, Kawano N, Noda Y, Nishioka K, Ando M, Aleksic B, Iidaka T, Ozaki N - BMC Psychiatry (2014)

Enlarged graphs for channels 17 and 22.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4067083&req=5

Figure 4: Enlarged graphs for channels 17 and 22.
Mentions: In both the ED group and the CTL group, the mean change in oxy-Hb concentration during the LFT was significantly correlated with the score on the SI subscale of the EDI-2 before significance levels were corrected by the false discovery rate method (Figures 3 and 4); however, the direction of the relation was opposite in the two groups. In the ED group, the mean change in oxy-Hb concentration during the LFT in channels 12, 16, 17, and 19–22 was positively correlated with SI score (r = 0.47 to 0.70, all p < 0.05), whereas in the CTL group, the mean change in oxy-Hb concentration during the LFT in channels 1, 5, 10, 13, 17, 18, and 22 was negatively correlated with SI score (r = -0.38 to -0.56, all p < 0.05). Additional tables show these findings in more detail (see Additional files 6 and 7).

Bottom Line: We hypothesized that frontal activity in patients with ED would be lower than in CTLs and would show different correlations with psychopathological features compared with CTLs.The mean change in oxygenated hemoglobin (oxy-Hb) in bilateral frontal regions during the LFT was significantly smaller in the ED group than in the CTL group.These results suggest that activity of the orbitofrontal cortex is associated with social insecurity and disturbed in patients with ED.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi-ken 466-8550, Japan. tanakas@med.nagoya-u.ac.jp.

ABSTRACT

Background: Functional neuroimaging techniques are widely used to elucidate changes in brain activity, and various questionnaires are used to investigate psychopathological features in patients with eating disorders (ED). It is well known that social skills and interpersonal difficulties are strongly associated with the psychopathology of patients with ED. However, few studies have examined the association between brain activity and social relationships in patients with ED, particularly in patients with extremely low body weight.

Methods: In this study, 22-channel near-infrared spectroscopy was used to quantify regional hemodynamic changes during a letter fluency task (LFT) in 20 female patients with ED with a mean body mass index of 14.0 kg/m(2) and 31 female controls (CTLs). Symptoms were assessed using the Eating Disorder Inventory-2 and Beck Depression Inventory. We hypothesized that frontal activity in patients with ED would be lower than in CTLs and would show different correlations with psychopathological features compared with CTLs.

Results: The LFT performance and score on the social insecurity subscale of the Eating Disorder Inventory-2 were significantly higher in the ED group than in the CTL group. The mean change in oxygenated hemoglobin (oxy-Hb) in bilateral frontal regions during the LFT was significantly smaller in the ED group than in the CTL group. Social insecurity score was positively correlated with the concentration of oxy-Hb in the bilateral orbitofrontal cortex in the ED group but not in the CTL group.

Conclusions: These results suggest that activity of the orbitofrontal cortex is associated with social insecurity and disturbed in patients with ED. Therefore, disturbed orbitofrontal cortex activity may underlie the lack of insight and social isolation that is characteristic of patients with ED.

Show MeSH
Related in: MedlinePlus