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Pleurodesis induction in rats by Copaiba (Copaifera multijuga Hayne) oil.

Westphal FL, Canzian M, Pieri FA, Reichl AC, Pêgo-Fernandes PM, Lima LC, Veiga-Junior VF - Biomed Res Int (2014)

Bottom Line: The grade of the alveolar edema mean was higher in the silver nitrate group in relation to the copaiba group, in which this alteration was not observed.The presence of bronchopneumonia was higher in the 24 h silver nitrate group (n = 4) in relation to the copaiba group (n = 0).In conclusion, both groups promoted pleurodesis, with better results in copaiba group and the silver nitrate group presented greater aggression to the pulmonary parenchyma.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitário Getúlio Vargas, Universidade Federal do Amazonas, Avenida Apurinã 4, Praça 14 de Janeiro, 69020-170 Manaus, AM, Brazil.

ABSTRACT
This study aims to assess and compare copaiba oleoresin of Copaifera multijuga and 0.5% silver nitrate for the induction of pleurodesis in an experimental model. Ninety-six male Wistar rats were divided into three groups: control (0.9% saline solution), copaiba (copaiba oil), and silver nitrate (0.5% silver nitrate). The substances were injected into the right pleural cavity and the alterations were observed macroscopically and microscopically at 24, 48, 72, and 504 h. The value of macroscopic alterations grade and acute inflammatory reaction grade means was higher in the 24 h copaiba group in relation to silver nitrate. Fibrosis and neovascularization means in the visceral pleura were higher in 504 h copaiba group in relation to the silver nitrate group. The grade of the alveolar edema mean was higher in the silver nitrate group in relation to the copaiba group, in which this alteration was not observed. The presence of bronchopneumonia was higher in the 24 h silver nitrate group (n = 4) in relation to the copaiba group (n = 0). In conclusion, both groups promoted pleurodesis, with better results in copaiba group and the silver nitrate group presented greater aggression to the pulmonary parenchyma.

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Distribution of means of scores presented in macroscopic and microscopic analysis after treatment with the substances, in different times. C: copaiba oil; N: silver nitrate; macro: macroscopic; API: acute parietal inflammation; AVI: acute visceral inflammation; CPI: chronic parietal inflammation; CVI: chronic visceral inflammation; PF: parietal fibrosis; VF: visceral fibrosis; T1: 24 h; T2: 48 h; T3: 72 h; T4: 504 h; P < 0.05 was considered as significant, presenting difference between the treatments.
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fig3: Distribution of means of scores presented in macroscopic and microscopic analysis after treatment with the substances, in different times. C: copaiba oil; N: silver nitrate; macro: macroscopic; API: acute parietal inflammation; AVI: acute visceral inflammation; CPI: chronic parietal inflammation; CVI: chronic visceral inflammation; PF: parietal fibrosis; VF: visceral fibrosis; T1: 24 h; T2: 48 h; T3: 72 h; T4: 504 h; P < 0.05 was considered as significant, presenting difference between the treatments.

Mentions: Macroscopic and microscopic changes related to the process of inflammation and acute and chronic fibrosis, both in the parietal and visceral pleura, in different times, are detailed in Figure 3. It demonstrates that copaiba oil presents more obvious macroscopic changes every time, with microscopic correspondence at 72 h and 504 h. It is observed that at times 24 h and 48 h there was no development of fibrosis in both groups, which was more evident at times 72 h and 504 h (Figure 3).


Pleurodesis induction in rats by Copaiba (Copaifera multijuga Hayne) oil.

Westphal FL, Canzian M, Pieri FA, Reichl AC, Pêgo-Fernandes PM, Lima LC, Veiga-Junior VF - Biomed Res Int (2014)

Distribution of means of scores presented in macroscopic and microscopic analysis after treatment with the substances, in different times. C: copaiba oil; N: silver nitrate; macro: macroscopic; API: acute parietal inflammation; AVI: acute visceral inflammation; CPI: chronic parietal inflammation; CVI: chronic visceral inflammation; PF: parietal fibrosis; VF: visceral fibrosis; T1: 24 h; T2: 48 h; T3: 72 h; T4: 504 h; P < 0.05 was considered as significant, presenting difference between the treatments.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4066724&req=5

fig3: Distribution of means of scores presented in macroscopic and microscopic analysis after treatment with the substances, in different times. C: copaiba oil; N: silver nitrate; macro: macroscopic; API: acute parietal inflammation; AVI: acute visceral inflammation; CPI: chronic parietal inflammation; CVI: chronic visceral inflammation; PF: parietal fibrosis; VF: visceral fibrosis; T1: 24 h; T2: 48 h; T3: 72 h; T4: 504 h; P < 0.05 was considered as significant, presenting difference between the treatments.
Mentions: Macroscopic and microscopic changes related to the process of inflammation and acute and chronic fibrosis, both in the parietal and visceral pleura, in different times, are detailed in Figure 3. It demonstrates that copaiba oil presents more obvious macroscopic changes every time, with microscopic correspondence at 72 h and 504 h. It is observed that at times 24 h and 48 h there was no development of fibrosis in both groups, which was more evident at times 72 h and 504 h (Figure 3).

Bottom Line: The grade of the alveolar edema mean was higher in the silver nitrate group in relation to the copaiba group, in which this alteration was not observed.The presence of bronchopneumonia was higher in the 24 h silver nitrate group (n = 4) in relation to the copaiba group (n = 0).In conclusion, both groups promoted pleurodesis, with better results in copaiba group and the silver nitrate group presented greater aggression to the pulmonary parenchyma.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitário Getúlio Vargas, Universidade Federal do Amazonas, Avenida Apurinã 4, Praça 14 de Janeiro, 69020-170 Manaus, AM, Brazil.

ABSTRACT
This study aims to assess and compare copaiba oleoresin of Copaifera multijuga and 0.5% silver nitrate for the induction of pleurodesis in an experimental model. Ninety-six male Wistar rats were divided into three groups: control (0.9% saline solution), copaiba (copaiba oil), and silver nitrate (0.5% silver nitrate). The substances were injected into the right pleural cavity and the alterations were observed macroscopically and microscopically at 24, 48, 72, and 504 h. The value of macroscopic alterations grade and acute inflammatory reaction grade means was higher in the 24 h copaiba group in relation to silver nitrate. Fibrosis and neovascularization means in the visceral pleura were higher in 504 h copaiba group in relation to the silver nitrate group. The grade of the alveolar edema mean was higher in the silver nitrate group in relation to the copaiba group, in which this alteration was not observed. The presence of bronchopneumonia was higher in the 24 h silver nitrate group (n = 4) in relation to the copaiba group (n = 0). In conclusion, both groups promoted pleurodesis, with better results in copaiba group and the silver nitrate group presented greater aggression to the pulmonary parenchyma.

Show MeSH
Related in: MedlinePlus