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Abdominal obesity is associated with heart disease in dogs.

Thengchaisri N, Theerapun W, Kaewmokul S, Sastravaha A - BMC Vet. Res. (2014)

Bottom Line: The following morphometric measurements were greater in the heart disease group compared with healthy canines: MBMI (65.0 ± 4.5 vs. 52.5 ± 3.7 kg/m2, respectively, P = 0.035); WIWDR (4.1 ± 0.1 vs. 3.1 ± 0.1, P < 0.01); and WTLR (1.25 ± 0.04 vs. 1.05 ± 0.04, P < 0.01).However, there was no significant difference in WHSDR (3.6 ± 0.1 vs. 3.7 ± 0.2, P = 0.875).Our data indicate that abdominal obesity, rather than overall obesity, is associated with heart disease in dogs.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, 50 Pahonyothin Rd,, Lat Yao, Chatuchak, Bangkok 10900, Thailand. ajnaris@yahoo.com.

ABSTRACT

Background: The relationship between overall obesity and fat distribution in dogs and the development of heart disease is unclear. In the present study we evaluated the association between overall obesity and fat distribution and clinical heart disease by morphometric and computed tomography (CT)-based measurements. Body condition score (BCS), modified body mass index (MBMI, kg/m2), waist-to-hock-to-stifle distance ratio (WHSDR), waist-to-ilium wing distance ratio (WIWDR), and waist-to-truncal length ratio (WTLR) were compared between dogs with (n = 44) and without (n = 43) heart disease using receiver operating characteristic (ROC) analysis. Intra-abdominal fat (IAF) and subcutaneous fat (SQF) were measured in dogs with (n = 8) and without (n = 9) heart disease at the center of the fourth and fifth lumbar vertebrae by CT.

Results: BCS was similar between heart disease and healthy groups (3.6 ± 0.2 vs. 3.3 ± 0.1, P = 0.126). The following morphometric measurements were greater in the heart disease group compared with healthy canines: MBMI (65.0 ± 4.5 vs. 52.5 ± 3.7 kg/m2, respectively, P = 0.035); WIWDR (4.1 ± 0.1 vs. 3.1 ± 0.1, P < 0.01); and WTLR (1.25 ± 0.04 vs. 1.05 ± 0.04, P < 0.01). However, there was no significant difference in WHSDR (3.6 ± 0.1 vs. 3.7 ± 0.2, P = 0.875). Interestingly, IAF was significantly increased in dogs with heart disease compared with healthy dogs (23.5 ± 1.5% vs. 19.4 ± 1.2%, P = 0.039) whereas SQF was similar between two groups (35.5 ± 2.7% vs. 38.6 ± 3.5%, P = 0.496). Of the five morphometric indices studied, WIWDR and WTLR provided acceptable discrimination for diagnosing heart disease in dogs, with areas under the ROC curve of 0.778 (95% confidence interval [CI]:0.683-0.874) and 0.727 (95% CI:0.619-0.835), respectively.

Conclusions: Our data indicate that abdominal obesity, rather than overall obesity, is associated with heart disease in dogs. Measurements of both WIWDR and WTLR are particular useful for detection of an abdominal obesity in dogs.

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The percentage of cross-sectional areas of subcutaneous and intra-abdominal fat between healthy dogs and dogs with heart disease. *P < 0.05.
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Figure 3: The percentage of cross-sectional areas of subcutaneous and intra-abdominal fat between healthy dogs and dogs with heart disease. *P < 0.05.

Mentions: Correlation analyses of fat measurements revealed that BCS was positively correlated with MBMI (r = 0.494, P < 0.01), WHSDR (r = 0.553, P < 0.01) and WTLR (r = 0.572, P < 0.01), but not with WIWDR (r = 0.182, P > 0.05) (Table 2). Furthermore, MBMI was significantly correlated with WIWDR (r = 0.303, P < 0.01) and WTLR (r = 0.690, P < 0.01), but not with WHSDR (r = 0.130, P > 0.05) (Table 2).We used CT to assess IAF and SQF at the center of the fourth and fifth vertebrae in dogs with or without heart disease (Figure 2). There was no significant difference in SQF between dogs in the heart disease group and those in the healthy group (35.5 ± 2.7% vs. 38.6 ± 3.5%, respectively; P = 0.50) (Figure 3); however, the amount of IAF of dogs in the heart disease group was significantly higher than that in the healthy group (23.5 ± 1.5% vs. 19.4 ± 1.2%; P = 0.04) (Figure 3). Moreover, the level of SQF was significantly higher than the level of IAF in both the heart disease and the healthy group.


Abdominal obesity is associated with heart disease in dogs.

Thengchaisri N, Theerapun W, Kaewmokul S, Sastravaha A - BMC Vet. Res. (2014)

The percentage of cross-sectional areas of subcutaneous and intra-abdominal fat between healthy dogs and dogs with heart disease. *P < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4066699&req=5

Figure 3: The percentage of cross-sectional areas of subcutaneous and intra-abdominal fat between healthy dogs and dogs with heart disease. *P < 0.05.
Mentions: Correlation analyses of fat measurements revealed that BCS was positively correlated with MBMI (r = 0.494, P < 0.01), WHSDR (r = 0.553, P < 0.01) and WTLR (r = 0.572, P < 0.01), but not with WIWDR (r = 0.182, P > 0.05) (Table 2). Furthermore, MBMI was significantly correlated with WIWDR (r = 0.303, P < 0.01) and WTLR (r = 0.690, P < 0.01), but not with WHSDR (r = 0.130, P > 0.05) (Table 2).We used CT to assess IAF and SQF at the center of the fourth and fifth vertebrae in dogs with or without heart disease (Figure 2). There was no significant difference in SQF between dogs in the heart disease group and those in the healthy group (35.5 ± 2.7% vs. 38.6 ± 3.5%, respectively; P = 0.50) (Figure 3); however, the amount of IAF of dogs in the heart disease group was significantly higher than that in the healthy group (23.5 ± 1.5% vs. 19.4 ± 1.2%; P = 0.04) (Figure 3). Moreover, the level of SQF was significantly higher than the level of IAF in both the heart disease and the healthy group.

Bottom Line: The following morphometric measurements were greater in the heart disease group compared with healthy canines: MBMI (65.0 ± 4.5 vs. 52.5 ± 3.7 kg/m2, respectively, P = 0.035); WIWDR (4.1 ± 0.1 vs. 3.1 ± 0.1, P < 0.01); and WTLR (1.25 ± 0.04 vs. 1.05 ± 0.04, P < 0.01).However, there was no significant difference in WHSDR (3.6 ± 0.1 vs. 3.7 ± 0.2, P = 0.875).Our data indicate that abdominal obesity, rather than overall obesity, is associated with heart disease in dogs.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, 50 Pahonyothin Rd,, Lat Yao, Chatuchak, Bangkok 10900, Thailand. ajnaris@yahoo.com.

ABSTRACT

Background: The relationship between overall obesity and fat distribution in dogs and the development of heart disease is unclear. In the present study we evaluated the association between overall obesity and fat distribution and clinical heart disease by morphometric and computed tomography (CT)-based measurements. Body condition score (BCS), modified body mass index (MBMI, kg/m2), waist-to-hock-to-stifle distance ratio (WHSDR), waist-to-ilium wing distance ratio (WIWDR), and waist-to-truncal length ratio (WTLR) were compared between dogs with (n = 44) and without (n = 43) heart disease using receiver operating characteristic (ROC) analysis. Intra-abdominal fat (IAF) and subcutaneous fat (SQF) were measured in dogs with (n = 8) and without (n = 9) heart disease at the center of the fourth and fifth lumbar vertebrae by CT.

Results: BCS was similar between heart disease and healthy groups (3.6 ± 0.2 vs. 3.3 ± 0.1, P = 0.126). The following morphometric measurements were greater in the heart disease group compared with healthy canines: MBMI (65.0 ± 4.5 vs. 52.5 ± 3.7 kg/m2, respectively, P = 0.035); WIWDR (4.1 ± 0.1 vs. 3.1 ± 0.1, P < 0.01); and WTLR (1.25 ± 0.04 vs. 1.05 ± 0.04, P < 0.01). However, there was no significant difference in WHSDR (3.6 ± 0.1 vs. 3.7 ± 0.2, P = 0.875). Interestingly, IAF was significantly increased in dogs with heart disease compared with healthy dogs (23.5 ± 1.5% vs. 19.4 ± 1.2%, P = 0.039) whereas SQF was similar between two groups (35.5 ± 2.7% vs. 38.6 ± 3.5%, P = 0.496). Of the five morphometric indices studied, WIWDR and WTLR provided acceptable discrimination for diagnosing heart disease in dogs, with areas under the ROC curve of 0.778 (95% confidence interval [CI]:0.683-0.874) and 0.727 (95% CI:0.619-0.835), respectively.

Conclusions: Our data indicate that abdominal obesity, rather than overall obesity, is associated with heart disease in dogs. Measurements of both WIWDR and WTLR are particular useful for detection of an abdominal obesity in dogs.

Show MeSH
Related in: MedlinePlus