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Indole alkaloids from marine sources as potential leads against infectious diseases.

França PH, Barbosa DP, da Silva DL, Ribeiro ÊA, Santana AE, Santos BV, Barbosa-Filho JM, Quintans JS, Barreto RS, Quintans-Júnior LJ, de Araújo-Júnior JX - Biomed Res Int (2014)

Bottom Line: Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources.Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents.In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.

ABSTRACT
Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

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Related in: MedlinePlus

Structures of hyrtioerectines D–F.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig14: Structures of hyrtioerectines D–F.

Mentions: Hyrtioerectines D–F (Figure 14) were isolated from Hyrtios species and had their antimicrobial activities screened. These β-carboline-derived compounds showed inhibition zones of 17, 9, and 14 mm against C. albicans compared to 35 mm illustrated by clotrimazole at the same concentration. In addition, they caused inhibition zones of 20, 10, and 16 mm against S. aureus, respectively, compared to 30 mm illustrated by ampicillin, as well as inhibition zones of 7–9 mm against Pseudomonas aeruginosa compared to 30 mm illustrated by imipenem [91].


Indole alkaloids from marine sources as potential leads against infectious diseases.

França PH, Barbosa DP, da Silva DL, Ribeiro ÊA, Santana AE, Santos BV, Barbosa-Filho JM, Quintans JS, Barreto RS, Quintans-Júnior LJ, de Araújo-Júnior JX - Biomed Res Int (2014)

Structures of hyrtioerectines D–F.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4066687&req=5

fig14: Structures of hyrtioerectines D–F.
Mentions: Hyrtioerectines D–F (Figure 14) were isolated from Hyrtios species and had their antimicrobial activities screened. These β-carboline-derived compounds showed inhibition zones of 17, 9, and 14 mm against C. albicans compared to 35 mm illustrated by clotrimazole at the same concentration. In addition, they caused inhibition zones of 20, 10, and 16 mm against S. aureus, respectively, compared to 30 mm illustrated by ampicillin, as well as inhibition zones of 7–9 mm against Pseudomonas aeruginosa compared to 30 mm illustrated by imipenem [91].

Bottom Line: Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources.Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents.In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.

ABSTRACT
Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

Show MeSH
Related in: MedlinePlus