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Indole alkaloids from marine sources as potential leads against infectious diseases.

França PH, Barbosa DP, da Silva DL, Ribeiro ÊA, Santana AE, Santos BV, Barbosa-Filho JM, Quintans JS, Barreto RS, Quintans-Júnior LJ, de Araújo-Júnior JX - Biomed Res Int (2014)

Bottom Line: Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources.Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents.In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.

ABSTRACT
Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

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Related in: MedlinePlus

Structures of meridianins C and G.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig13: Structures of meridianins C and G.

Mentions: Meridianins A-G (Figure 13) comprise indole alkaloids substituted at the C-3 position by a 2-aminopyridine ring and had been previously isolated from the tunicate Aplidium meridianum. Investigations on the antimalarial and antileishmanial activity of meridianin C and G were carried out and showed that these two compounds inhibited P. falciparum D6 and W2 clones with IC50 values in the range of 4.4 to 14.4 μM. Meridianin C was also active against L. donovani promastigotes showing an IC50 value of 64 μM [89].


Indole alkaloids from marine sources as potential leads against infectious diseases.

França PH, Barbosa DP, da Silva DL, Ribeiro ÊA, Santana AE, Santos BV, Barbosa-Filho JM, Quintans JS, Barreto RS, Quintans-Júnior LJ, de Araújo-Júnior JX - Biomed Res Int (2014)

Structures of meridianins C and G.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4066687&req=5

fig13: Structures of meridianins C and G.
Mentions: Meridianins A-G (Figure 13) comprise indole alkaloids substituted at the C-3 position by a 2-aminopyridine ring and had been previously isolated from the tunicate Aplidium meridianum. Investigations on the antimalarial and antileishmanial activity of meridianin C and G were carried out and showed that these two compounds inhibited P. falciparum D6 and W2 clones with IC50 values in the range of 4.4 to 14.4 μM. Meridianin C was also active against L. donovani promastigotes showing an IC50 value of 64 μM [89].

Bottom Line: Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources.Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents.In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.

ABSTRACT
Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

Show MeSH
Related in: MedlinePlus