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Indole alkaloids from marine sources as potential leads against infectious diseases.

França PH, Barbosa DP, da Silva DL, Ribeiro ÊA, Santana AE, Santos BV, Barbosa-Filho JM, Quintans JS, Barreto RS, Quintans-Júnior LJ, de Araújo-Júnior JX - Biomed Res Int (2014)

Bottom Line: Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources.Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents.In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.

ABSTRACT
Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

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Related in: MedlinePlus

Structures of marinacarbolines and pendolmycin derivative.
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Related In: Results  -  Collection


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fig7: Structures of marinacarbolines and pendolmycin derivative.

Mentions: Alkaloids obtained from the fermentation broth of Marinactinospora thermotolerans SCSIO 0652 were tested for their antiplasmodial activities against P. falciparum line 3D7, a drug-sensitive strain, and Dd2, a multi-drug-resistant strain. The results of the antiplasmodial assays revealed that marinacarboline A (Figure 7) and methylpendolmycin-14-O-α-glucoside (Figure 6) inhibited P. falciparum line Dd2 with IC50 values of 1.92 and 5.03 μM, respectively, and marinacarbolines C and D inhibited P. falciparum lines 3D7 and Dd2 with IC50 values between 3.09 and 5.39 μM [82].


Indole alkaloids from marine sources as potential leads against infectious diseases.

França PH, Barbosa DP, da Silva DL, Ribeiro ÊA, Santana AE, Santos BV, Barbosa-Filho JM, Quintans JS, Barreto RS, Quintans-Júnior LJ, de Araújo-Júnior JX - Biomed Res Int (2014)

Structures of marinacarbolines and pendolmycin derivative.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4066687&req=5

fig7: Structures of marinacarbolines and pendolmycin derivative.
Mentions: Alkaloids obtained from the fermentation broth of Marinactinospora thermotolerans SCSIO 0652 were tested for their antiplasmodial activities against P. falciparum line 3D7, a drug-sensitive strain, and Dd2, a multi-drug-resistant strain. The results of the antiplasmodial assays revealed that marinacarboline A (Figure 7) and methylpendolmycin-14-O-α-glucoside (Figure 6) inhibited P. falciparum line Dd2 with IC50 values of 1.92 and 5.03 μM, respectively, and marinacarbolines C and D inhibited P. falciparum lines 3D7 and Dd2 with IC50 values between 3.09 and 5.39 μM [82].

Bottom Line: Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources.Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents.In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.

ABSTRACT
Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

Show MeSH
Related in: MedlinePlus