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Indole alkaloids from marine sources as potential leads against infectious diseases.

França PH, Barbosa DP, da Silva DL, Ribeiro ÊA, Santana AE, Santos BV, Barbosa-Filho JM, Quintans JS, Barreto RS, Quintans-Júnior LJ, de Araújo-Júnior JX - Biomed Res Int (2014)

Bottom Line: Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources.Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents.In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.

ABSTRACT
Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

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Related in: MedlinePlus

Structures of β-carbolines with eudistomin-derived scaffold and simple β-carbolines.
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Related In: Results  -  Collection


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fig2: Structures of β-carbolines with eudistomin-derived scaffold and simple β-carbolines.

Mentions: Seven β-carboline-based metabolites, designated as eudistomins Y1–Y7 (Figure 2), were isolated from a tunicate of the genus Eudistoma collected in South Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the β-carboline nucleus at C-1. Eudistomin Y6 exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermidis ATCC12228 and B. subtilis ATCC 6633 with MIC values of 12.5 and 25 μg/mL, respectively, but showed no inhibitory activity toward the other two strains of Gram-positive bacteria, S. aureus ATCC 6538 and M. lutes ATCC 9341, and the Gram-negative bacteria including E. coli ATCC 11775, Salmonella typhimurium ATCC 14028, and Klebsiella pneumoniae ATCC 4352. Eudistomins Y1 and Y4 also displayed the same selectivity as eudistomin Y6 but demonstrated weak antibacterial activity against the two strains of bacteria S. epidermidis ATCC12228 and B. subtilis ATCC 6633 with MICs of 50 and 200 μg/mL, respectively [68].


Indole alkaloids from marine sources as potential leads against infectious diseases.

França PH, Barbosa DP, da Silva DL, Ribeiro ÊA, Santana AE, Santos BV, Barbosa-Filho JM, Quintans JS, Barreto RS, Quintans-Júnior LJ, de Araújo-Júnior JX - Biomed Res Int (2014)

Structures of β-carbolines with eudistomin-derived scaffold and simple β-carbolines.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4066687&req=5

fig2: Structures of β-carbolines with eudistomin-derived scaffold and simple β-carbolines.
Mentions: Seven β-carboline-based metabolites, designated as eudistomins Y1–Y7 (Figure 2), were isolated from a tunicate of the genus Eudistoma collected in South Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the β-carboline nucleus at C-1. Eudistomin Y6 exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermidis ATCC12228 and B. subtilis ATCC 6633 with MIC values of 12.5 and 25 μg/mL, respectively, but showed no inhibitory activity toward the other two strains of Gram-positive bacteria, S. aureus ATCC 6538 and M. lutes ATCC 9341, and the Gram-negative bacteria including E. coli ATCC 11775, Salmonella typhimurium ATCC 14028, and Klebsiella pneumoniae ATCC 4352. Eudistomins Y1 and Y4 also displayed the same selectivity as eudistomin Y6 but demonstrated weak antibacterial activity against the two strains of bacteria S. epidermidis ATCC12228 and B. subtilis ATCC 6633 with MICs of 50 and 200 μg/mL, respectively [68].

Bottom Line: Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources.Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents.In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.

ABSTRACT
Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

Show MeSH
Related in: MedlinePlus