Limits...
The relationship between interleukin-18 polymorphisms and allergic disease: a meta-analysis.

Cheng D, Hao Y, Zhou W, Ma Y - Biomed Res Int (2014)

Bottom Line: Recent studies have suggested that IL-18 -607C/A and -137G/C polymorphisms may be associated with the risk of allergic disease; however, individually published results are inconclusive.In the overall analysis and the subgroup analysis according to ethnicity, we did not find significant association between IL-18 -607C/A or -137G/C polymorphism and the risk of allergic disease (all P > 0.05).In the stratified analysis by source of control, IL-18-607C/A showed significantly reduced risk in population-based subgroup, and for IL-18 -137G/C only significantly decreased risk was found in the hospital-based subgroup.

View Article: PubMed Central - PubMed

Affiliation: Department of Transfusion, The First Hospital of China Medical University, North Nanjing Street, No. 155, Shenyang, Liaoning 110001, China.

ABSTRACT
Recent studies have suggested that IL-18 -607C/A and -137G/C polymorphisms may be associated with the risk of allergic disease; however, individually published results are inconclusive. Therefore, we performed a meta-analysis to clarify whether IL-18 -607C/A and -137G/C polymorphisms were associated with the risk of allergic disease. A total of 21 studies including 5,331 cases and 9,658 controls were involved in this meta-analysis. In the overall analysis and the subgroup analysis according to ethnicity, we did not find significant association between IL-18 -607C/A or -137G/C polymorphism and the risk of allergic disease (all P > 0.05). However, in a stratified analysis by type of allergic disease, our results indicated that IL-18 -607C/A polymorphism was associated with a significantly decreased risk of allergic asthma in heterozygous comparison and IL-18 -137G/C was associated with a significantly decreased risk of allergic dermatitis in recessive model and homozygous comparison. In the stratified analysis by source of control, IL-18-607C/A showed significantly reduced risk in population-based subgroup, and for IL-18 -137G/C only significantly decreased risk was found in the hospital-based subgroup. Our meta-analysis suggests that IL-18 -607C/A and -137G/C polymorphisms may be protective factors for the risk of allergic asthma and allergic dermatitis, respectively.

Show MeSH

Related in: MedlinePlus

Forest plots for IL-18 −137G/C polymorphism and allergic disease risk under dominant model. (a) Subgroup analysis by types of disease. (b) Subgroup analysis by ethnicity. (c) Subgroup analysis by source of control.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4066680&req=5

fig3: Forest plots for IL-18 −137G/C polymorphism and allergic disease risk under dominant model. (a) Subgroup analysis by types of disease. (b) Subgroup analysis by ethnicity. (c) Subgroup analysis by source of control.

Mentions: For IL-18 −137G/C polymorphism, a total of 5,067 cases and 9,379 controls were included in the meta-analysis. We found significant between-study heterogeneity under allele model (I2 = 73%), dominant model (I2 = 67%), and heterozygous comparison (I2 = 56%) and the random-effects model was used, whereas the fixed-effect model was used in recessive model (I2 = 39%) and homozygous comparison (I2 = 46%). In the overall analysis, we did not find significant association between IL-18 −137G/C polymorphism and the risk of allergic disease under all models (C allele versus G allele: OR = 0.93, 95% CI = 0.80–1.07, P = 0.31; CC + CG versus GG: OR = 0.97, 95% CI = 0.82–1.14, P = 0.70; CC versus CG + GG: OR = 0.77, 95% CI = 0.58–1.02, P = 0.07; CC versus GG: OR = 0.76, 95% CI = 0.55–1.04, P = 0.08; CG versus GG: OR = 1.02, 95% CI = 0.88–1.18, P = 0.78, Figure 3). When the data were stratified by the type of allergic disease, a significant association between IL-18 −137G/C polymorphism and AD was found under recessive model (CC versus CG + GG: OR = 0.30, 95% CI = 0.15–0.60, P < 0.001) and homozygous comparison (CC versus GG: OR = 0.26, 95% CI = 0.12–0.53, P < 0.001). In the subgroup analysis by ethnicity, the results suggested that IL-18 −137G/C polymorphism was not associated with the risk of allergic disease (all P > 0.05 under all models) in Asian and Caucasian populations. In a stratified analysis by source of control, only significantly decreased risk was found in the hospital-based subgroup under recessive model (OR = 0.72, 95% CI = 0.54–0.96, P = 0.03) and homozygous comparison (OR = 0.72, 95% CI = 0.53–0.97, P = 0.03).


The relationship between interleukin-18 polymorphisms and allergic disease: a meta-analysis.

Cheng D, Hao Y, Zhou W, Ma Y - Biomed Res Int (2014)

Forest plots for IL-18 −137G/C polymorphism and allergic disease risk under dominant model. (a) Subgroup analysis by types of disease. (b) Subgroup analysis by ethnicity. (c) Subgroup analysis by source of control.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4066680&req=5

fig3: Forest plots for IL-18 −137G/C polymorphism and allergic disease risk under dominant model. (a) Subgroup analysis by types of disease. (b) Subgroup analysis by ethnicity. (c) Subgroup analysis by source of control.
Mentions: For IL-18 −137G/C polymorphism, a total of 5,067 cases and 9,379 controls were included in the meta-analysis. We found significant between-study heterogeneity under allele model (I2 = 73%), dominant model (I2 = 67%), and heterozygous comparison (I2 = 56%) and the random-effects model was used, whereas the fixed-effect model was used in recessive model (I2 = 39%) and homozygous comparison (I2 = 46%). In the overall analysis, we did not find significant association between IL-18 −137G/C polymorphism and the risk of allergic disease under all models (C allele versus G allele: OR = 0.93, 95% CI = 0.80–1.07, P = 0.31; CC + CG versus GG: OR = 0.97, 95% CI = 0.82–1.14, P = 0.70; CC versus CG + GG: OR = 0.77, 95% CI = 0.58–1.02, P = 0.07; CC versus GG: OR = 0.76, 95% CI = 0.55–1.04, P = 0.08; CG versus GG: OR = 1.02, 95% CI = 0.88–1.18, P = 0.78, Figure 3). When the data were stratified by the type of allergic disease, a significant association between IL-18 −137G/C polymorphism and AD was found under recessive model (CC versus CG + GG: OR = 0.30, 95% CI = 0.15–0.60, P < 0.001) and homozygous comparison (CC versus GG: OR = 0.26, 95% CI = 0.12–0.53, P < 0.001). In the subgroup analysis by ethnicity, the results suggested that IL-18 −137G/C polymorphism was not associated with the risk of allergic disease (all P > 0.05 under all models) in Asian and Caucasian populations. In a stratified analysis by source of control, only significantly decreased risk was found in the hospital-based subgroup under recessive model (OR = 0.72, 95% CI = 0.54–0.96, P = 0.03) and homozygous comparison (OR = 0.72, 95% CI = 0.53–0.97, P = 0.03).

Bottom Line: Recent studies have suggested that IL-18 -607C/A and -137G/C polymorphisms may be associated with the risk of allergic disease; however, individually published results are inconclusive.In the overall analysis and the subgroup analysis according to ethnicity, we did not find significant association between IL-18 -607C/A or -137G/C polymorphism and the risk of allergic disease (all P > 0.05).In the stratified analysis by source of control, IL-18-607C/A showed significantly reduced risk in population-based subgroup, and for IL-18 -137G/C only significantly decreased risk was found in the hospital-based subgroup.

View Article: PubMed Central - PubMed

Affiliation: Department of Transfusion, The First Hospital of China Medical University, North Nanjing Street, No. 155, Shenyang, Liaoning 110001, China.

ABSTRACT
Recent studies have suggested that IL-18 -607C/A and -137G/C polymorphisms may be associated with the risk of allergic disease; however, individually published results are inconclusive. Therefore, we performed a meta-analysis to clarify whether IL-18 -607C/A and -137G/C polymorphisms were associated with the risk of allergic disease. A total of 21 studies including 5,331 cases and 9,658 controls were involved in this meta-analysis. In the overall analysis and the subgroup analysis according to ethnicity, we did not find significant association between IL-18 -607C/A or -137G/C polymorphism and the risk of allergic disease (all P > 0.05). However, in a stratified analysis by type of allergic disease, our results indicated that IL-18 -607C/A polymorphism was associated with a significantly decreased risk of allergic asthma in heterozygous comparison and IL-18 -137G/C was associated with a significantly decreased risk of allergic dermatitis in recessive model and homozygous comparison. In the stratified analysis by source of control, IL-18-607C/A showed significantly reduced risk in population-based subgroup, and for IL-18 -137G/C only significantly decreased risk was found in the hospital-based subgroup. Our meta-analysis suggests that IL-18 -607C/A and -137G/C polymorphisms may be protective factors for the risk of allergic asthma and allergic dermatitis, respectively.

Show MeSH
Related in: MedlinePlus