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Cytomegalovirus retinitis in acquired immunodeficiency syndrome patients: A problem worth giving attention to.

Gupta PK, Patel NV, Patel SD, Patel KJ - Indian J Sex Transm Dis (2014)

Bottom Line: Out of 800 patients registered with CD4 <150 cells/µl in ART center, 100 patients reached us.CMV retinitis occurs even in patients with higher CD4 counts.Timely diagnosis and intervention of this treatable condition can reduce the number of blinding years in these young patients who otherwise live longer as a result of HAART.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Government Medical College, Surat, Gujarat, India.

ABSTRACT

Background: Cytomegalovirus (CMV) retinitis remains the most common ocular opportunistic infection in patients with acquired immunodeficiency syndrome even in the era of highly active antiretroviral therapy (HAART). Increased survival of patients on HAART has increased incidence of blindness, which will further increase in the future. The objective of this study was to determine the incidence of CMV retinitis and the effect of HAART on the natural history of CMV retinitis in patients referred from ART center.

Materials and methods: Patients with baseline/current CD4 counts <150 cells/µl were evaluated for CMV retinitis. Complete ophthalmological evaluation was carried out and records of CD4 counts, HAART regime, presence of any form of CMV retinitis and response to HAART were noted.

Results: Out of 800 patients registered with CD4 <150 cells/µl in ART center, 100 patients reached us. Among these, CMV retinitis was observed in 15% patients, with median CD4 count at the time of examination being 56 cells/µl (range: 24-306 cells/µl). 66.67% patients were HAART non-responders and 63.6% eyes were economically blind.

Conclusion: CMV retinitis occurs even in patients with higher CD4 counts. Timely diagnosis and intervention of this treatable condition can reduce the number of blinding years in these young patients who otherwise live longer as a result of HAART.

No MeSH data available.


Related in: MedlinePlus

Active classic hemorrhagic pattern in an 18-year-old male with CD4 counts of 24 cells/μl on the second line highly active antiretroviral therapy
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Figure 1: Active classic hemorrhagic pattern in an 18-year-old male with CD4 counts of 24 cells/μl on the second line highly active antiretroviral therapy

Mentions: In patients with CMV retinitis, 54.5% had active disease [Table 3] of which 75% patients had classic hemorrhagic pattern [Figure 1], 8% had frosted branch angiitis [Figure 2] and17% had granular pattern [Figure 3 and Table 4]. Nearly 22.7% of patients had healed/necrotic lesions [Figure 4]. 22.7% had advanced disease with retinal detachment


Cytomegalovirus retinitis in acquired immunodeficiency syndrome patients: A problem worth giving attention to.

Gupta PK, Patel NV, Patel SD, Patel KJ - Indian J Sex Transm Dis (2014)

Active classic hemorrhagic pattern in an 18-year-old male with CD4 counts of 24 cells/μl on the second line highly active antiretroviral therapy
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4066592&req=5

Figure 1: Active classic hemorrhagic pattern in an 18-year-old male with CD4 counts of 24 cells/μl on the second line highly active antiretroviral therapy
Mentions: In patients with CMV retinitis, 54.5% had active disease [Table 3] of which 75% patients had classic hemorrhagic pattern [Figure 1], 8% had frosted branch angiitis [Figure 2] and17% had granular pattern [Figure 3 and Table 4]. Nearly 22.7% of patients had healed/necrotic lesions [Figure 4]. 22.7% had advanced disease with retinal detachment

Bottom Line: Out of 800 patients registered with CD4 <150 cells/µl in ART center, 100 patients reached us.CMV retinitis occurs even in patients with higher CD4 counts.Timely diagnosis and intervention of this treatable condition can reduce the number of blinding years in these young patients who otherwise live longer as a result of HAART.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Government Medical College, Surat, Gujarat, India.

ABSTRACT

Background: Cytomegalovirus (CMV) retinitis remains the most common ocular opportunistic infection in patients with acquired immunodeficiency syndrome even in the era of highly active antiretroviral therapy (HAART). Increased survival of patients on HAART has increased incidence of blindness, which will further increase in the future. The objective of this study was to determine the incidence of CMV retinitis and the effect of HAART on the natural history of CMV retinitis in patients referred from ART center.

Materials and methods: Patients with baseline/current CD4 counts <150 cells/µl were evaluated for CMV retinitis. Complete ophthalmological evaluation was carried out and records of CD4 counts, HAART regime, presence of any form of CMV retinitis and response to HAART were noted.

Results: Out of 800 patients registered with CD4 <150 cells/µl in ART center, 100 patients reached us. Among these, CMV retinitis was observed in 15% patients, with median CD4 count at the time of examination being 56 cells/µl (range: 24-306 cells/µl). 66.67% patients were HAART non-responders and 63.6% eyes were economically blind.

Conclusion: CMV retinitis occurs even in patients with higher CD4 counts. Timely diagnosis and intervention of this treatable condition can reduce the number of blinding years in these young patients who otherwise live longer as a result of HAART.

No MeSH data available.


Related in: MedlinePlus