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Postexercise improvement in insulin-stimulated glucose uptake occurs concomitant with greater AS160 phosphorylation in muscle from normal and insulin-resistant rats.

Castorena CM, Arias EB, Sharma N, Cartee GD - Diabetes (2014)

Bottom Line: Furthermore, insulin-stimulated GU for LFD-3hPEX was greater than HFD-3hPEX values.For HFD-3hPEX muscles, pAS160 exceeded HFD-Sedentary, but in muscle from LFD-3hPEX rats, pAS160 was greater still than HFD-3hPEX values.These results implicated pAS160 as a potential determinant of the exercise-induced elevation in insulin-stimulated GU for each diet group and also revealed pAS160 as a possible mediator of greater postexercise GU of insulin-stimulated muscles from the insulin-sensitive versus insulin-resistant group.

View Article: PubMed Central - PubMed

Affiliation: Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI.

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Total protein abundance for IR, IRS-1, Akt, AS160, and GLUT4. Data were analyzed by two-way ANOVA within each insulin level (minus or plus insulin). There were no significant differences for the total abundance of any of these proteins.
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Figure 4: Total protein abundance for IR, IRS-1, Akt, AS160, and GLUT4. Data were analyzed by two-way ANOVA within each insulin level (minus or plus insulin). There were no significant differences for the total abundance of any of these proteins.

Mentions: Neither diet nor exercise significantly altered the total protein abundance of IR, IRS-1, Akt, AS160, or GLUT4 (Fig. 4).


Postexercise improvement in insulin-stimulated glucose uptake occurs concomitant with greater AS160 phosphorylation in muscle from normal and insulin-resistant rats.

Castorena CM, Arias EB, Sharma N, Cartee GD - Diabetes (2014)

Total protein abundance for IR, IRS-1, Akt, AS160, and GLUT4. Data were analyzed by two-way ANOVA within each insulin level (minus or plus insulin). There were no significant differences for the total abundance of any of these proteins.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4066340&req=5

Figure 4: Total protein abundance for IR, IRS-1, Akt, AS160, and GLUT4. Data were analyzed by two-way ANOVA within each insulin level (minus or plus insulin). There were no significant differences for the total abundance of any of these proteins.
Mentions: Neither diet nor exercise significantly altered the total protein abundance of IR, IRS-1, Akt, AS160, or GLUT4 (Fig. 4).

Bottom Line: Furthermore, insulin-stimulated GU for LFD-3hPEX was greater than HFD-3hPEX values.For HFD-3hPEX muscles, pAS160 exceeded HFD-Sedentary, but in muscle from LFD-3hPEX rats, pAS160 was greater still than HFD-3hPEX values.These results implicated pAS160 as a potential determinant of the exercise-induced elevation in insulin-stimulated GU for each diet group and also revealed pAS160 as a possible mediator of greater postexercise GU of insulin-stimulated muscles from the insulin-sensitive versus insulin-resistant group.

View Article: PubMed Central - PubMed

Affiliation: Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI.

Show MeSH
Related in: MedlinePlus