Postexercise improvement in insulin-stimulated glucose uptake occurs concomitant with greater AS160 phosphorylation in muscle from normal and insulin-resistant rats.
Bottom Line: Furthermore, insulin-stimulated GU for LFD-3hPEX was greater than HFD-3hPEX values.For HFD-3hPEX muscles, pAS160 exceeded HFD-Sedentary, but in muscle from LFD-3hPEX rats, pAS160 was greater still than HFD-3hPEX values.These results implicated pAS160 as a potential determinant of the exercise-induced elevation in insulin-stimulated GU for each diet group and also revealed pAS160 as a possible mediator of greater postexercise GU of insulin-stimulated muscles from the insulin-sensitive versus insulin-resistant group.
Affiliation: Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI.Show MeSH
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Affiliation: Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI.