Glucose sensing in the peritoneal space offers faster kinetics than sensing in the subcutaneous space.
Bottom Line: We compared the temporal response characteristics of simultaneously placed subcutaneous and intraperitoneal sensors during intravenous glucose tolerance tests in eight swine.Using compartmental modeling based on simultaneous intravenous sensing, blood draws, and intraarterial sensing, we found that intraperitoneal kinetics were more than twice as fast as subcutaneous kinetics (mean time constant of 5.6 min for intraperitoneal vs. 12.4 min for subcutaneous).Combined with the known faster kinetics of intraperitoneal insulin delivery over subcutaneous delivery, our findings suggest that artificial pancreas technologies may be optimized by sensing glucose and delivering insulin in the intraperitoneal space.
Affiliation: Theranova, LLC, San Francisco, CA.Show MeSH
Related in: MedlinePlus
Mentions: Figure 1A shows raw sensor current data from a hyperglycemia challenge. Of note are the rapid rise and fall of the intravascular (intraarterial and intravenous) sensors, and the less rapid waveforms from the extravascular (intraperitoneal and subcutaneous) sensors. Figure 1B illustrates the response-time analysis described above, in which latency (a measure of how rapidly the tissue glucose increases after a vascular bolus) and recovery (a measure of how rapidly the tissue glucose decreases as the vascular glucose decreases over 35 min postbolus) were read from each sensor curve.