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Altered Neuronal Dynamics in the Striatum on the Behavior of Huntingtin Interacting Protein 14 (HIP14) Knockout Mice.

Estrada-Sánchez AM, Barton SJ, Rebec GV - Brain Sci (2013)

Bottom Line: Growing evidence suggests that huntingtin interacting protein 14 (HIP14) contributes to HD neuropathology.Striatal LFP activity anticipates this difference.Our results suggest that HIP14 plays a critical role in the aberrant behavioral modulation of striatal neuronal activity underlying motor inflexibility, including the motor signs of HD.

View Article: PubMed Central - PubMed

Affiliation: Program in Neuroscience, Indiana University, Bloomington, IN 47405, USA.

ABSTRACT
Huntington's disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene, impairs information processing in the striatum, which, as part of the basal ganglia, modulates motor output. Growing evidence suggests that huntingtin interacting protein 14 (HIP14) contributes to HD neuropathology. Here, we recorded local field potentials (LFPs) in the striatum as HIP14 knockout mice and wild-type controls freely navigated a plus-shaped maze. Upon entering the choice point of the maze, HIP14 knockouts tend to continue in a straight line, turning left or right significantly less often than wild-types, a sign of motor inflexibility that also occurs in HD mice. Striatal LFP activity anticipates this difference. In wild-types, the power spectral density pattern associated with entry into the choice point differs significantly from the pattern immediately before entry, especially at low frequencies (≤13 Hz), whereas HIP14 knockouts show no change in LFP activity as they enter the choice point. The lack of change in striatal activity may explain the turning deficit in the plus maze. Our results suggest that HIP14 plays a critical role in the aberrant behavioral modulation of striatal neuronal activity underlying motor inflexibility, including the motor signs of HD.

No MeSH data available.


Related in: MedlinePlus

Striatal local field potential (LFP) activity recorded from wild-type and HIP14 knockout mice before and after entry into the choice point. Spectrogram plots were obtained 2 s before and 2 s after the wild-type (A) and HIP14 knockout (B) mice enter the center of the maze (denoted by zero). Graphs were obtained from the average of the total of crossing events obtained from 5 wild-type (339 events) and 6 HIP14 knockout mice (701 events).
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brainsci-03-01588-f002: Striatal local field potential (LFP) activity recorded from wild-type and HIP14 knockout mice before and after entry into the choice point. Spectrogram plots were obtained 2 s before and 2 s after the wild-type (A) and HIP14 knockout (B) mice enter the center of the maze (denoted by zero). Graphs were obtained from the average of the total of crossing events obtained from 5 wild-type (339 events) and 6 HIP14 knockout mice (701 events).

Mentions: Because evaluating patterns of arm choice provides information on behavioral flexibility, we focused our analysis of striatal LFP activity on events surrounding the choice point. We first constructed spectrograms based on total entries into the choice point obtained from five randomly selected wild-type (339 entries) and six HIP14 knockout mice (701 entries). As shown in Figure 2, two seconds before entering the choice point (denoted by zero), both groups showed high power at low frequencies [delta (0.1–4 Hz), theta (4–7 Hz)]. Note, however, that when the mice cross the choice point, LFP power decreases only in wild-types; HIP14 knockouts maintain the same level of power at low frequencies.


Altered Neuronal Dynamics in the Striatum on the Behavior of Huntingtin Interacting Protein 14 (HIP14) Knockout Mice.

Estrada-Sánchez AM, Barton SJ, Rebec GV - Brain Sci (2013)

Striatal local field potential (LFP) activity recorded from wild-type and HIP14 knockout mice before and after entry into the choice point. Spectrogram plots were obtained 2 s before and 2 s after the wild-type (A) and HIP14 knockout (B) mice enter the center of the maze (denoted by zero). Graphs were obtained from the average of the total of crossing events obtained from 5 wild-type (339 events) and 6 HIP14 knockout mice (701 events).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061888&req=5

brainsci-03-01588-f002: Striatal local field potential (LFP) activity recorded from wild-type and HIP14 knockout mice before and after entry into the choice point. Spectrogram plots were obtained 2 s before and 2 s after the wild-type (A) and HIP14 knockout (B) mice enter the center of the maze (denoted by zero). Graphs were obtained from the average of the total of crossing events obtained from 5 wild-type (339 events) and 6 HIP14 knockout mice (701 events).
Mentions: Because evaluating patterns of arm choice provides information on behavioral flexibility, we focused our analysis of striatal LFP activity on events surrounding the choice point. We first constructed spectrograms based on total entries into the choice point obtained from five randomly selected wild-type (339 entries) and six HIP14 knockout mice (701 entries). As shown in Figure 2, two seconds before entering the choice point (denoted by zero), both groups showed high power at low frequencies [delta (0.1–4 Hz), theta (4–7 Hz)]. Note, however, that when the mice cross the choice point, LFP power decreases only in wild-types; HIP14 knockouts maintain the same level of power at low frequencies.

Bottom Line: Growing evidence suggests that huntingtin interacting protein 14 (HIP14) contributes to HD neuropathology.Striatal LFP activity anticipates this difference.Our results suggest that HIP14 plays a critical role in the aberrant behavioral modulation of striatal neuronal activity underlying motor inflexibility, including the motor signs of HD.

View Article: PubMed Central - PubMed

Affiliation: Program in Neuroscience, Indiana University, Bloomington, IN 47405, USA.

ABSTRACT
Huntington's disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene, impairs information processing in the striatum, which, as part of the basal ganglia, modulates motor output. Growing evidence suggests that huntingtin interacting protein 14 (HIP14) contributes to HD neuropathology. Here, we recorded local field potentials (LFPs) in the striatum as HIP14 knockout mice and wild-type controls freely navigated a plus-shaped maze. Upon entering the choice point of the maze, HIP14 knockouts tend to continue in a straight line, turning left or right significantly less often than wild-types, a sign of motor inflexibility that also occurs in HD mice. Striatal LFP activity anticipates this difference. In wild-types, the power spectral density pattern associated with entry into the choice point differs significantly from the pattern immediately before entry, especially at low frequencies (≤13 Hz), whereas HIP14 knockouts show no change in LFP activity as they enter the choice point. The lack of change in striatal activity may explain the turning deficit in the plus maze. Our results suggest that HIP14 plays a critical role in the aberrant behavioral modulation of striatal neuronal activity underlying motor inflexibility, including the motor signs of HD.

No MeSH data available.


Related in: MedlinePlus