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Impact of Repetitive Transcranial Magnetic Stimulation (rTMS) on Brain Functional Marker of Auditory Hallucinations in Schizophrenia Patients.

Maïza O, Hervé PY, Etard O, Razafimandimby A, Montagne-Larmurier A, Dollfus S - Brain Sci (2013)

Bottom Line: Before rTMS, activations were negatively correlated with AHRS in a left posterior superior temporal sulcus (pSTS) cluster, considered henceforward as a functional region of interest (fROI).This decoupling was explained by a significant decrease of AHRS scores after rTMS that contrasted with a relative stability of cerebral activations.A voxel-based-morphometry analysis evidenced a cluster of the left pSTS where grey matter volume negatively correlated with AHRS before rTMS and positively correlated with activations in the fROI at both sessions. rTMS decreases the severity of AVH leading to modify the functional correlate of AVH underlain by grey matter abnormalities.

View Article: PubMed Central - PubMed

Affiliation: CHU de Caen, Service Universitaire de Psychiatrie, Centre Esquirol, Caen 14000, France. razafima@cyceron.fr.

ABSTRACT

Unlabelled: Several cross-sectional functional Magnetic Resonance Imaging (fMRI) studies reported a negative correlation between auditory verbal hallucination (AVH) severity and amplitude of the activations during language tasks. The present study assessed the time course of this correlation and its possible structural underpinnings by combining structural, functional MRI and repetitive Transcranial Magnetic Stimulation (rTMS).

Methods: Nine schizophrenia patients with AVH (evaluated with the Auditory Hallucination Rating scale; AHRS) and nine healthy participants underwent two sessions of an fMRI speech listening paradigm. Meanwhile, patients received high frequency (20 Hz) rTMS.

Results: Before rTMS, activations were negatively correlated with AHRS in a left posterior superior temporal sulcus (pSTS) cluster, considered henceforward as a functional region of interest (fROI). After rTMS, activations in this fROI no longer correlated with AHRS. This decoupling was explained by a significant decrease of AHRS scores after rTMS that contrasted with a relative stability of cerebral activations. A voxel-based-morphometry analysis evidenced a cluster of the left pSTS where grey matter volume negatively correlated with AHRS before rTMS and positively correlated with activations in the fROI at both sessions.

Conclusion: rTMS decreases the severity of AVH leading to modify the functional correlate of AVH underlain by grey matter abnormalities.

No MeSH data available.


Related in: MedlinePlus

Correlation between baseline Blood Oxygen Level Dependent (BOLD) signal variations and baseline Auditory Hallucination Rating Scale (AHRS) scores.
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brainsci-03-00728-f002: Correlation between baseline Blood Oxygen Level Dependent (BOLD) signal variations and baseline Auditory Hallucination Rating Scale (AHRS) scores.

Mentions: The severity of hallucinations, assessed with the AHRS, was negatively correlated with brain activations in the posterior part of the left superior temporal sulcus (STS) (x = −50, y = −42, z = 10; 17 voxels; Figure 2).


Impact of Repetitive Transcranial Magnetic Stimulation (rTMS) on Brain Functional Marker of Auditory Hallucinations in Schizophrenia Patients.

Maïza O, Hervé PY, Etard O, Razafimandimby A, Montagne-Larmurier A, Dollfus S - Brain Sci (2013)

Correlation between baseline Blood Oxygen Level Dependent (BOLD) signal variations and baseline Auditory Hallucination Rating Scale (AHRS) scores.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061846&req=5

brainsci-03-00728-f002: Correlation between baseline Blood Oxygen Level Dependent (BOLD) signal variations and baseline Auditory Hallucination Rating Scale (AHRS) scores.
Mentions: The severity of hallucinations, assessed with the AHRS, was negatively correlated with brain activations in the posterior part of the left superior temporal sulcus (STS) (x = −50, y = −42, z = 10; 17 voxels; Figure 2).

Bottom Line: Before rTMS, activations were negatively correlated with AHRS in a left posterior superior temporal sulcus (pSTS) cluster, considered henceforward as a functional region of interest (fROI).This decoupling was explained by a significant decrease of AHRS scores after rTMS that contrasted with a relative stability of cerebral activations.A voxel-based-morphometry analysis evidenced a cluster of the left pSTS where grey matter volume negatively correlated with AHRS before rTMS and positively correlated with activations in the fROI at both sessions. rTMS decreases the severity of AVH leading to modify the functional correlate of AVH underlain by grey matter abnormalities.

View Article: PubMed Central - PubMed

Affiliation: CHU de Caen, Service Universitaire de Psychiatrie, Centre Esquirol, Caen 14000, France. razafima@cyceron.fr.

ABSTRACT

Unlabelled: Several cross-sectional functional Magnetic Resonance Imaging (fMRI) studies reported a negative correlation between auditory verbal hallucination (AVH) severity and amplitude of the activations during language tasks. The present study assessed the time course of this correlation and its possible structural underpinnings by combining structural, functional MRI and repetitive Transcranial Magnetic Stimulation (rTMS).

Methods: Nine schizophrenia patients with AVH (evaluated with the Auditory Hallucination Rating scale; AHRS) and nine healthy participants underwent two sessions of an fMRI speech listening paradigm. Meanwhile, patients received high frequency (20 Hz) rTMS.

Results: Before rTMS, activations were negatively correlated with AHRS in a left posterior superior temporal sulcus (pSTS) cluster, considered henceforward as a functional region of interest (fROI). After rTMS, activations in this fROI no longer correlated with AHRS. This decoupling was explained by a significant decrease of AHRS scores after rTMS that contrasted with a relative stability of cerebral activations. A voxel-based-morphometry analysis evidenced a cluster of the left pSTS where grey matter volume negatively correlated with AHRS before rTMS and positively correlated with activations in the fROI at both sessions.

Conclusion: rTMS decreases the severity of AVH leading to modify the functional correlate of AVH underlain by grey matter abnormalities.

No MeSH data available.


Related in: MedlinePlus