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Neurovascular coupling of the posterior cerebral artery in spinal cord injury: a pilot study.

Phillips AA, Krassioukov AV, Zheng MM, Warburton DE - Brain Sci (2013)

Bottom Line: Heart rate and end-tidal carbon dioxide responded similarly between groups.Clearly, NVC is impaired in those with SCI.This study may provide a link between poor perfusion of the posterior cerebral region (containing the medullary autonomic centres) and autonomic dysfunction after SCI.

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver V6T 1Z1, Canada. andrei.krassioukov@vch.ca.

ABSTRACT

Purpose: To compare neurovascular coupling in the posterior cerebral artery (PCA) between those with spinal cord injury (SCI) and able bodied (AB) individuals.

Methods: A total of seven SCI and seven AB were matched for age and sex. Measures included PCA velocity (PCAv), beat-by-beat blood pressure and end-tidal carbon dioxide. Posterior cerebral cortex activation was achieved by 10 cycles of (1) 30 s eyes closed (pre-stimulation), (2) 30 s reading (stimulation).

Results: Blood pressure was significantly reduced in those with SCI (SBP: 100 ± 13 mmHg; DBP: 58 ± 13 mmHg) vs.

Ab (sbp: 121 ± 12 mmHg; DBP: 74 ± 9 mmHg) during both pre-stimulation and stimulation, but the relative increase was similar during the stimulation period. Changes in PCAv during stimulation were mitigated in the SCI group (6% ± 6%) vs. AB (29% ± 12%, P < 0.001). Heart rate and end-tidal carbon dioxide responded similarly between groups.

Conclusions: Clearly, NVC is impaired in those with SCI. This study may provide a link between poor perfusion of the posterior cerebral region (containing the medullary autonomic centres) and autonomic dysfunction after SCI.

No MeSH data available.


Related in: MedlinePlus

Individual data for mean arterial pressure (MAP; left) and posterior cerebral artery mean blood flow velocity (PCAvmean; right) pre- and post-visual stimulation. Black hash-lines represent those with SCI (spinal cord injury). Blue solid slides represent able-bodied individuals.
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brainsci-03-00781-f001: Individual data for mean arterial pressure (MAP; left) and posterior cerebral artery mean blood flow velocity (PCAvmean; right) pre- and post-visual stimulation. Black hash-lines represent those with SCI (spinal cord injury). Blue solid slides represent able-bodied individuals.

Mentions: The average pre-stimulation PCAv was similar between the AB (37 ± 6 cm/s) and SCI (37 ± 10 cm/s) participants (Table 1). The increase in mean PCAv during the stimulation period was significantly lower in SCI (6% ± 6%) as compared to AB (29% ± 12%). Similarly, increases in both systolic and end-diastolic PCAv during the stimulation task were reduced in the SCI group (Table 1). Individual data is presented in Figure 1.


Neurovascular coupling of the posterior cerebral artery in spinal cord injury: a pilot study.

Phillips AA, Krassioukov AV, Zheng MM, Warburton DE - Brain Sci (2013)

Individual data for mean arterial pressure (MAP; left) and posterior cerebral artery mean blood flow velocity (PCAvmean; right) pre- and post-visual stimulation. Black hash-lines represent those with SCI (spinal cord injury). Blue solid slides represent able-bodied individuals.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061840&req=5

brainsci-03-00781-f001: Individual data for mean arterial pressure (MAP; left) and posterior cerebral artery mean blood flow velocity (PCAvmean; right) pre- and post-visual stimulation. Black hash-lines represent those with SCI (spinal cord injury). Blue solid slides represent able-bodied individuals.
Mentions: The average pre-stimulation PCAv was similar between the AB (37 ± 6 cm/s) and SCI (37 ± 10 cm/s) participants (Table 1). The increase in mean PCAv during the stimulation period was significantly lower in SCI (6% ± 6%) as compared to AB (29% ± 12%). Similarly, increases in both systolic and end-diastolic PCAv during the stimulation task were reduced in the SCI group (Table 1). Individual data is presented in Figure 1.

Bottom Line: Heart rate and end-tidal carbon dioxide responded similarly between groups.Clearly, NVC is impaired in those with SCI.This study may provide a link between poor perfusion of the posterior cerebral region (containing the medullary autonomic centres) and autonomic dysfunction after SCI.

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver V6T 1Z1, Canada. andrei.krassioukov@vch.ca.

ABSTRACT

Purpose: To compare neurovascular coupling in the posterior cerebral artery (PCA) between those with spinal cord injury (SCI) and able bodied (AB) individuals.

Methods: A total of seven SCI and seven AB were matched for age and sex. Measures included PCA velocity (PCAv), beat-by-beat blood pressure and end-tidal carbon dioxide. Posterior cerebral cortex activation was achieved by 10 cycles of (1) 30 s eyes closed (pre-stimulation), (2) 30 s reading (stimulation).

Results: Blood pressure was significantly reduced in those with SCI (SBP: 100 ± 13 mmHg; DBP: 58 ± 13 mmHg) vs.

Ab (sbp: 121 ± 12 mmHg; DBP: 74 ± 9 mmHg) during both pre-stimulation and stimulation, but the relative increase was similar during the stimulation period. Changes in PCAv during stimulation were mitigated in the SCI group (6% ± 6%) vs. AB (29% ± 12%, P < 0.001). Heart rate and end-tidal carbon dioxide responded similarly between groups.

Conclusions: Clearly, NVC is impaired in those with SCI. This study may provide a link between poor perfusion of the posterior cerebral region (containing the medullary autonomic centres) and autonomic dysfunction after SCI.

No MeSH data available.


Related in: MedlinePlus