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Wnt Signaling in Neurogenesis during Aging and Physical Activity.

Chen M, Do H - Brain Sci (2012)

Bottom Line: Relatively little is known, however, about how aging and physical activity affect the Wnt signaling pathway.Herein, we briefly review the salient features of neurogenesis in young and then in old adult animals.Then, we discuss Wnt signaling and review the very few in vitro and in vivo studies that have examined the Wnt signaling pathways in aging and physical activity.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological Sciences, California State University, 5151 State University Drive, Los Angeles, CA 90032, USA. mchen@calstatela.edu.

ABSTRACT
Over the past decade, much progress has been made regarding our understanding of neurogenesis in both young and old animals and where it occurs throughout the lifespan, although the growth of new neurons declines with increasing age. In addition, physical activity can reverse this age-dependent decline in neurogenesis. Highly correlated with this decline is the degree of inter and intracellular Wnt signaling, the molecular mechanisms of which have only recently started to be elucidated. So far, most of what we know about intracellular signaling during/following exercise centers around the CREB/CRE initiated transcriptional events. Relatively little is known, however, about how aging and physical activity affect the Wnt signaling pathway. Herein, we briefly review the salient features of neurogenesis in young and then in old adult animals. Then, we discuss Wnt signaling and review the very few in vitro and in vivo studies that have examined the Wnt signaling pathways in aging and physical activity.

No MeSH data available.


Related in: MedlinePlus

Wnts are secreted by astrocytes, neural stem cells or neural progenitor cells. Wnts are transcribed and translated and then acetylated by the acetyltransferase, Porcupine (Porc), in the endoplasmic reticulum. On the trans face of the Golgi, is a multimeric protein, called wntless, which aids in the transfer of Wnts to endosomes. Upon fusion of the two membranes, Wnt is secreted to the exterior of the cell.
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brainsci-02-00745-f001: Wnts are secreted by astrocytes, neural stem cells or neural progenitor cells. Wnts are transcribed and translated and then acetylated by the acetyltransferase, Porcupine (Porc), in the endoplasmic reticulum. On the trans face of the Golgi, is a multimeric protein, called wntless, which aids in the transfer of Wnts to endosomes. Upon fusion of the two membranes, Wnt is secreted to the exterior of the cell.

Mentions: Wnts are postranslationally acetylated in the endoplasmic reticulum by an acetyltransferase, called porcupine (Figure 1). Following transfer and subsequent removal from the Golgi, another protein, called Wntless, acts like a chaperone for the transfer of Wnts to endosomes, whose membrane fuses with the plasma membrane, resulting in the secretion of Wnts to the extracellular space [37], Figure 1. What follows is a brief review highlighting the three Wnts that have been shown to play the largest roles in adult hippocampal neurogenesis: Wnt3(a), Wnt1 and Wnt7(a).


Wnt Signaling in Neurogenesis during Aging and Physical Activity.

Chen M, Do H - Brain Sci (2012)

Wnts are secreted by astrocytes, neural stem cells or neural progenitor cells. Wnts are transcribed and translated and then acetylated by the acetyltransferase, Porcupine (Porc), in the endoplasmic reticulum. On the trans face of the Golgi, is a multimeric protein, called wntless, which aids in the transfer of Wnts to endosomes. Upon fusion of the two membranes, Wnt is secreted to the exterior of the cell.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061808&req=5

brainsci-02-00745-f001: Wnts are secreted by astrocytes, neural stem cells or neural progenitor cells. Wnts are transcribed and translated and then acetylated by the acetyltransferase, Porcupine (Porc), in the endoplasmic reticulum. On the trans face of the Golgi, is a multimeric protein, called wntless, which aids in the transfer of Wnts to endosomes. Upon fusion of the two membranes, Wnt is secreted to the exterior of the cell.
Mentions: Wnts are postranslationally acetylated in the endoplasmic reticulum by an acetyltransferase, called porcupine (Figure 1). Following transfer and subsequent removal from the Golgi, another protein, called Wntless, acts like a chaperone for the transfer of Wnts to endosomes, whose membrane fuses with the plasma membrane, resulting in the secretion of Wnts to the extracellular space [37], Figure 1. What follows is a brief review highlighting the three Wnts that have been shown to play the largest roles in adult hippocampal neurogenesis: Wnt3(a), Wnt1 and Wnt7(a).

Bottom Line: Relatively little is known, however, about how aging and physical activity affect the Wnt signaling pathway.Herein, we briefly review the salient features of neurogenesis in young and then in old adult animals.Then, we discuss Wnt signaling and review the very few in vitro and in vivo studies that have examined the Wnt signaling pathways in aging and physical activity.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological Sciences, California State University, 5151 State University Drive, Los Angeles, CA 90032, USA. mchen@calstatela.edu.

ABSTRACT
Over the past decade, much progress has been made regarding our understanding of neurogenesis in both young and old animals and where it occurs throughout the lifespan, although the growth of new neurons declines with increasing age. In addition, physical activity can reverse this age-dependent decline in neurogenesis. Highly correlated with this decline is the degree of inter and intracellular Wnt signaling, the molecular mechanisms of which have only recently started to be elucidated. So far, most of what we know about intracellular signaling during/following exercise centers around the CREB/CRE initiated transcriptional events. Relatively little is known, however, about how aging and physical activity affect the Wnt signaling pathway. Herein, we briefly review the salient features of neurogenesis in young and then in old adult animals. Then, we discuss Wnt signaling and review the very few in vitro and in vivo studies that have examined the Wnt signaling pathways in aging and physical activity.

No MeSH data available.


Related in: MedlinePlus