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Nicotine exposure increases the complexity of dopamine neurons in the parainterfascicular nucleus (PIF) sub-region of VTA.

Zhang D, Dragomir A, Akay YM, Akay M - J Neuroeng Rehabil (2014)

Bottom Line: Approximate entropy values were then grouped according to each anatomic location including the PBP, PIF and PN.Our results have shown that the local field potentials corresponding to the neurons located in the PIF region of the VTA have ApEn values significantly higher (p = 2x10-4) in the maternal nicotine cases when compared to the saline.Therefore, we speculate that the dopamine neurons located in the PIF sub-region of the VTA are very likely involved with the nicotine addiction.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Biomedical Engineering, Cullen College of Engineering, University of Houston, Houston, TX 77204, USA. makay@uh.edu.

ABSTRACT

Background: Recent publications highlight differences within the sub-regions of the ventral tegmental area (VTA) including the parabrachial pigmented nucleus (PBP), parainterfascicular nucleus (PIF) and paranigral nucleus (PN) in the projections to the prefrontal cortex (PFC) and the glutamatergic pathway.

Methods: In order to characterize the effects of prenatal nicotine exposure on the mesocorticolimbic system of the rat offspring, local field potentials were recorded from 27 sites across the VTA of 9 rats aged 40-55 days. The extracellular VTA neural activities were analyzed using Approximate Entropy (ApEn) method. Approximate entropy values were then grouped according to each anatomic location including the PBP, PIF and PN.

Results: Our results have shown that the local field potentials corresponding to the neurons located in the PIF region of the VTA have ApEn values significantly higher (p = 2x10-4) in the maternal nicotine cases when compared to the saline.

Conclusion: Therefore, we speculate that the dopamine neurons located in the PIF sub-region of the VTA are very likely involved with the nicotine addiction.

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Related in: MedlinePlus

Gestational nicotine significantly increased the approximate entropy values of LFPs in PIF. This bar plot shows the alterations on approximate entropy values between gestational nicotine treated group and control group in PBP, PIF and PN. The difference in the case of the PIF is statistically significant when comparing between control and Gestational nicotine exposure.
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Figure 3: Gestational nicotine significantly increased the approximate entropy values of LFPs in PIF. This bar plot shows the alterations on approximate entropy values between gestational nicotine treated group and control group in PBP, PIF and PN. The difference in the case of the PIF is statistically significant when comparing between control and Gestational nicotine exposure.

Mentions: We generally observed slower oscillatory rhythms within the PIF sub-region of the control group (saline-treated dams), while faster oscillations were observed in the PIF of maternal nicotine exposure group. The slower, rhythmic oscillations are usually a hallmark of synchronous neural activity of the neurons, while the faster and generally smaller amplitude oscillations in the latter case may be an indicator of less synchronized, more random neural activity in the respective area. Throughout the recordings most of the power was found in the [0–3] Hz frequency band, consistent with the observations of previous studies.Figure 3 summarizes the results for all rats under study. The mean approximate entropy values estimated from LFPs recorded within the PBP sub-region were 0.37 ± 0.009 (SEM) and 0.39 ± 0.005 for the rats in control group and maternal nicotine exposure group, respectively. The largest differences were observed for the PIF sub-region, where the mean values were 0.28 ± 0.007 (control) and 0.43 ± 0.01 (maternal nicotine exposure), while in the case of the PN the mean approximate entropy values were 0.38 ± 0.01 (control) and 0.39 ± 0.009 (maternal nicotine exposure).


Nicotine exposure increases the complexity of dopamine neurons in the parainterfascicular nucleus (PIF) sub-region of VTA.

Zhang D, Dragomir A, Akay YM, Akay M - J Neuroeng Rehabil (2014)

Gestational nicotine significantly increased the approximate entropy values of LFPs in PIF. This bar plot shows the alterations on approximate entropy values between gestational nicotine treated group and control group in PBP, PIF and PN. The difference in the case of the PIF is statistically significant when comparing between control and Gestational nicotine exposure.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4061779&req=5

Figure 3: Gestational nicotine significantly increased the approximate entropy values of LFPs in PIF. This bar plot shows the alterations on approximate entropy values between gestational nicotine treated group and control group in PBP, PIF and PN. The difference in the case of the PIF is statistically significant when comparing between control and Gestational nicotine exposure.
Mentions: We generally observed slower oscillatory rhythms within the PIF sub-region of the control group (saline-treated dams), while faster oscillations were observed in the PIF of maternal nicotine exposure group. The slower, rhythmic oscillations are usually a hallmark of synchronous neural activity of the neurons, while the faster and generally smaller amplitude oscillations in the latter case may be an indicator of less synchronized, more random neural activity in the respective area. Throughout the recordings most of the power was found in the [0–3] Hz frequency band, consistent with the observations of previous studies.Figure 3 summarizes the results for all rats under study. The mean approximate entropy values estimated from LFPs recorded within the PBP sub-region were 0.37 ± 0.009 (SEM) and 0.39 ± 0.005 for the rats in control group and maternal nicotine exposure group, respectively. The largest differences were observed for the PIF sub-region, where the mean values were 0.28 ± 0.007 (control) and 0.43 ± 0.01 (maternal nicotine exposure), while in the case of the PN the mean approximate entropy values were 0.38 ± 0.01 (control) and 0.39 ± 0.009 (maternal nicotine exposure).

Bottom Line: Approximate entropy values were then grouped according to each anatomic location including the PBP, PIF and PN.Our results have shown that the local field potentials corresponding to the neurons located in the PIF region of the VTA have ApEn values significantly higher (p = 2x10-4) in the maternal nicotine cases when compared to the saline.Therefore, we speculate that the dopamine neurons located in the PIF sub-region of the VTA are very likely involved with the nicotine addiction.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Biomedical Engineering, Cullen College of Engineering, University of Houston, Houston, TX 77204, USA. makay@uh.edu.

ABSTRACT

Background: Recent publications highlight differences within the sub-regions of the ventral tegmental area (VTA) including the parabrachial pigmented nucleus (PBP), parainterfascicular nucleus (PIF) and paranigral nucleus (PN) in the projections to the prefrontal cortex (PFC) and the glutamatergic pathway.

Methods: In order to characterize the effects of prenatal nicotine exposure on the mesocorticolimbic system of the rat offspring, local field potentials were recorded from 27 sites across the VTA of 9 rats aged 40-55 days. The extracellular VTA neural activities were analyzed using Approximate Entropy (ApEn) method. Approximate entropy values were then grouped according to each anatomic location including the PBP, PIF and PN.

Results: Our results have shown that the local field potentials corresponding to the neurons located in the PIF region of the VTA have ApEn values significantly higher (p = 2x10-4) in the maternal nicotine cases when compared to the saline.

Conclusion: Therefore, we speculate that the dopamine neurons located in the PIF sub-region of the VTA are very likely involved with the nicotine addiction.

Show MeSH
Related in: MedlinePlus