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The stem cell secretome and its role in brain repair.

Drago D, Cossetti C, Iraci N, Gaude E, Musco G, Bachi A, Pluchino S - Biochimie (2013)

Bottom Line: In this paradigm, significant repair of the injured brain may be achieved by injecting the biologics secreted by stem cells (secretome), rather than implanting stem cells themselves for direct cell replacement.This review discusses the most recent identification of MSC- and NPC-secreted factors, including those that are trafficked within extracellular membrane vesicles (EVs), and reflects on their potential effects on brain repair.It also examines some of the most convincing advances in molecular profiling that have enabled mapping of the SCS.

View Article: PubMed Central - PubMed

Affiliation: CNS Repair Unit, Institute of Experimental Neurology, Division of Neurosciences, San Raffaele Scientific Institute, 20132 Milan, Italy; Biomolecular Mass Spectrometry Unit, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy. Electronic address: drago.denise@hsr.it.

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Proposed model for the therapeutic application of mesenchymal/neural stem cell secretome in CNS repair.Exchange of signals between grafted MSCs or NPCs and the host lead to remarkable tissue trophic effects on endogenous brain cells and beneficial modulatory actions on innate and adaptive immune responses, which ultimately promote the healing of the injured CNS. The characterization of the SCS is one of the main challenges of proteomics and metabolomics applied to neuroscience. Coupling of preconditioned media with bioengineered materials may be employed to control and sustain the expression of customized secretome and possibly extend the duration of the observed therapeutic effects.
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Figure 1: Proposed model for the therapeutic application of mesenchymal/neural stem cell secretome in CNS repair.Exchange of signals between grafted MSCs or NPCs and the host lead to remarkable tissue trophic effects on endogenous brain cells and beneficial modulatory actions on innate and adaptive immune responses, which ultimately promote the healing of the injured CNS. The characterization of the SCS is one of the main challenges of proteomics and metabolomics applied to neuroscience. Coupling of preconditioned media with bioengineered materials may be employed to control and sustain the expression of customized secretome and possibly extend the duration of the observed therapeutic effects.

Mentions: In conclusion, beyond the great enthusiasm for new treatment perspectives, much investigative work is still in progress on the development of robust and customized SCS-based future therapeutics, paving the way for new regenerative medicine approaches to CNS repair (Fig. 1).


The stem cell secretome and its role in brain repair.

Drago D, Cossetti C, Iraci N, Gaude E, Musco G, Bachi A, Pluchino S - Biochimie (2013)

Proposed model for the therapeutic application of mesenchymal/neural stem cell secretome in CNS repair.Exchange of signals between grafted MSCs or NPCs and the host lead to remarkable tissue trophic effects on endogenous brain cells and beneficial modulatory actions on innate and adaptive immune responses, which ultimately promote the healing of the injured CNS. The characterization of the SCS is one of the main challenges of proteomics and metabolomics applied to neuroscience. Coupling of preconditioned media with bioengineered materials may be employed to control and sustain the expression of customized secretome and possibly extend the duration of the observed therapeutic effects.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061727&req=5

Figure 1: Proposed model for the therapeutic application of mesenchymal/neural stem cell secretome in CNS repair.Exchange of signals between grafted MSCs or NPCs and the host lead to remarkable tissue trophic effects on endogenous brain cells and beneficial modulatory actions on innate and adaptive immune responses, which ultimately promote the healing of the injured CNS. The characterization of the SCS is one of the main challenges of proteomics and metabolomics applied to neuroscience. Coupling of preconditioned media with bioengineered materials may be employed to control and sustain the expression of customized secretome and possibly extend the duration of the observed therapeutic effects.
Mentions: In conclusion, beyond the great enthusiasm for new treatment perspectives, much investigative work is still in progress on the development of robust and customized SCS-based future therapeutics, paving the way for new regenerative medicine approaches to CNS repair (Fig. 1).

Bottom Line: In this paradigm, significant repair of the injured brain may be achieved by injecting the biologics secreted by stem cells (secretome), rather than implanting stem cells themselves for direct cell replacement.This review discusses the most recent identification of MSC- and NPC-secreted factors, including those that are trafficked within extracellular membrane vesicles (EVs), and reflects on their potential effects on brain repair.It also examines some of the most convincing advances in molecular profiling that have enabled mapping of the SCS.

View Article: PubMed Central - PubMed

Affiliation: CNS Repair Unit, Institute of Experimental Neurology, Division of Neurosciences, San Raffaele Scientific Institute, 20132 Milan, Italy; Biomolecular Mass Spectrometry Unit, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy. Electronic address: drago.denise@hsr.it.

Show MeSH
Related in: MedlinePlus