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Cunninghamella spinosum fungal corneal ulcer- first case report.

Bhandary SV, VijayaPai H, Rao LG, Yegneswaran PP - Indian J Ophthalmol (2014)

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kasturba Medical College, Manipal, Karnataka, India.

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Sir, Cunninghamella species are mainly soil fungi of the Mediterranean and subtropical zones, and less commonly found in temperate regions... However, C.bertholletiae is the only species known to cause disease in man and animals.Cunninghamella is an opportunistic fungus seen to affect diabetics and immunocompromised individuals... It can present as rhinocerebral, pulmonary, cutaneoarticular or disseminated forms... Literature review did not reveal any case report of Cunninghamella spinosum causing ocular involvement till date... We report a rare case of corneal ulcer caused by Cunninghamella spinosum... He was not a diabetic and there was no history suggestive of immunocompromised state... The genus Cunninghamella is characterized by white to gray, rapidly growing colonies, producing erect, straight, branching sporangiophores ending in globose or pyriform-shaped vesicles from which several one-celled, globose to ovoid, echinulate or smooth-walled swollen sporangiola attached by denticles develop... C.bertholletiae causes infections in immunocompromised patients leading to devastating results and it is known to cause infection in the bone marrow transplant patients, pneumonia and mucormycosis... We report this rare case of fungal corneal ulcer by this opportunistic fungus C. spinosum in a patient who was not immunocompromised... It is important to note that the species C.spinosum is not known to affect human race... Although most of the systemic conditions caused by this cunninghamella species are known to cause devastating results, our patient responded well to Natamycin and Azole antifungal agents.

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Central corneal infiltrate, no hypopyon not a typical fungal ulcer on clinical appearance
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Figure 1: Central corneal infiltrate, no hypopyon not a typical fungal ulcer on clinical appearance

Mentions: A 54-year-old male presented with history of injury to the left eye with a stick 11 days ago. He complained of diminution of vision, pain, redness, watering and discharge from the left eye, five days after the injury. He was not a diabetic and there was no history suggestive of immunocompromised state. His visual acuity in left eye at presentation was hand movements. Anterior segment examination revealed a corneal ulcer with infiltrate measuring 7 × 8 mm involving central and paracentral zone of the cornea. [Figs. 1 and 2] There was no hypopyon, satellite lesions or endothelial plaque. Anterior chamber showed grade 3 reaction.


Cunninghamella spinosum fungal corneal ulcer- first case report.

Bhandary SV, VijayaPai H, Rao LG, Yegneswaran PP - Indian J Ophthalmol (2014)

Central corneal infiltrate, no hypopyon not a typical fungal ulcer on clinical appearance
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061691&req=5

Figure 1: Central corneal infiltrate, no hypopyon not a typical fungal ulcer on clinical appearance
Mentions: A 54-year-old male presented with history of injury to the left eye with a stick 11 days ago. He complained of diminution of vision, pain, redness, watering and discharge from the left eye, five days after the injury. He was not a diabetic and there was no history suggestive of immunocompromised state. His visual acuity in left eye at presentation was hand movements. Anterior segment examination revealed a corneal ulcer with infiltrate measuring 7 × 8 mm involving central and paracentral zone of the cornea. [Figs. 1 and 2] There was no hypopyon, satellite lesions or endothelial plaque. Anterior chamber showed grade 3 reaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kasturba Medical College, Manipal, Karnataka, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Cunninghamella species are mainly soil fungi of the Mediterranean and subtropical zones, and less commonly found in temperate regions... However, C.bertholletiae is the only species known to cause disease in man and animals.Cunninghamella is an opportunistic fungus seen to affect diabetics and immunocompromised individuals... It can present as rhinocerebral, pulmonary, cutaneoarticular or disseminated forms... Literature review did not reveal any case report of Cunninghamella spinosum causing ocular involvement till date... We report a rare case of corneal ulcer caused by Cunninghamella spinosum... He was not a diabetic and there was no history suggestive of immunocompromised state... The genus Cunninghamella is characterized by white to gray, rapidly growing colonies, producing erect, straight, branching sporangiophores ending in globose or pyriform-shaped vesicles from which several one-celled, globose to ovoid, echinulate or smooth-walled swollen sporangiola attached by denticles develop... C.bertholletiae causes infections in immunocompromised patients leading to devastating results and it is known to cause infection in the bone marrow transplant patients, pneumonia and mucormycosis... We report this rare case of fungal corneal ulcer by this opportunistic fungus C. spinosum in a patient who was not immunocompromised... It is important to note that the species C.spinosum is not known to affect human race... Although most of the systemic conditions caused by this cunninghamella species are known to cause devastating results, our patient responded well to Natamycin and Azole antifungal agents.

Show MeSH
Related in: MedlinePlus