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Collagen cross-linking in the treatment of pellucid marginal degeneration.

Hassan Z, Nemeth G, Modis L, Szalai E, Berta A - Indian J Ophthalmol (2014)

Bottom Line: Uncorrected, LogMAR visual acuity has improved from +0.8 to +0.55 during the 6 months and +0.3 during the 8 months follow-up after CXL.Keratometric values and topografic indexes disclosed no progression of the disease.CXL may postpone or eliminate the need of corneal transplantation in cases with PMD.

View Article: PubMed Central - PubMed

Affiliation: Orbident Refractive Surgery and Medical Center, University of Debrecen, Debrecen, Hungary.

ABSTRACT
Pellucid marginal degeneration (PMD) is an uncommon cause of inferior peripheral corneal thinning disorder, characterized by irregular astigmatism. We analyzed a case of bilateral PMD patient and treated one eye with corneal collagen cross-linking (CXL) therapy. Corneal topography was characteristic for PMD. Visual acuity, slitlamp examinations, tonometry, and corneal thickness were observed. Simulated keratometric and topographic index values were detected with corneal topography. Uncorrected, LogMAR visual acuity has improved from +0.8 to +0.55 during the 6 months and +0.3 during the 8 months follow-up after CXL. Pachymetry values and intraocular pressure showed no changes. Keratometric values and topografic indexes disclosed no progression of the disease. CXL may postpone or eliminate the need of corneal transplantation in cases with PMD.

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Related in: MedlinePlus

Slit-lamp photograph of the right eye shows inferior steepening with a clear zone between limbus and the steep band
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Figure 1: Slit-lamp photograph of the right eye shows inferior steepening with a clear zone between limbus and the steep band

Mentions: Ophthalmic examination revealed his best-uncorrected visual acuity, a value of +0.8 in the right eye and +0.1 in the left eye observed with a logarithmic scale (LogMAR). Slitlamp examination of the cornea showed inferior peripheral corneal-thinning without iron lines, vascularization, or lipid deposition [Fig. 1]. The lesion was nonulcerative and inflammatory, and implied the protrusion of the cornea. Between the thinned area and the limbus, the corneal thickness was normal. However, the left eye showed a clear band of peripheral thinning about 1–2 mm wide, with anterior protrusion of the cornea just above the thinned area. A 2.0-mm zone of normal-thickness cornea was seen between the thinned area and the limbus. Scheimpflug image (Oculus Pentacam HR) of the anterior segment of the right eye shows irregular shaped central corneal region [Fig. 2a and b].


Collagen cross-linking in the treatment of pellucid marginal degeneration.

Hassan Z, Nemeth G, Modis L, Szalai E, Berta A - Indian J Ophthalmol (2014)

Slit-lamp photograph of the right eye shows inferior steepening with a clear zone between limbus and the steep band
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061688&req=5

Figure 1: Slit-lamp photograph of the right eye shows inferior steepening with a clear zone between limbus and the steep band
Mentions: Ophthalmic examination revealed his best-uncorrected visual acuity, a value of +0.8 in the right eye and +0.1 in the left eye observed with a logarithmic scale (LogMAR). Slitlamp examination of the cornea showed inferior peripheral corneal-thinning without iron lines, vascularization, or lipid deposition [Fig. 1]. The lesion was nonulcerative and inflammatory, and implied the protrusion of the cornea. Between the thinned area and the limbus, the corneal thickness was normal. However, the left eye showed a clear band of peripheral thinning about 1–2 mm wide, with anterior protrusion of the cornea just above the thinned area. A 2.0-mm zone of normal-thickness cornea was seen between the thinned area and the limbus. Scheimpflug image (Oculus Pentacam HR) of the anterior segment of the right eye shows irregular shaped central corneal region [Fig. 2a and b].

Bottom Line: Uncorrected, LogMAR visual acuity has improved from +0.8 to +0.55 during the 6 months and +0.3 during the 8 months follow-up after CXL.Keratometric values and topografic indexes disclosed no progression of the disease.CXL may postpone or eliminate the need of corneal transplantation in cases with PMD.

View Article: PubMed Central - PubMed

Affiliation: Orbident Refractive Surgery and Medical Center, University of Debrecen, Debrecen, Hungary.

ABSTRACT
Pellucid marginal degeneration (PMD) is an uncommon cause of inferior peripheral corneal thinning disorder, characterized by irregular astigmatism. We analyzed a case of bilateral PMD patient and treated one eye with corneal collagen cross-linking (CXL) therapy. Corneal topography was characteristic for PMD. Visual acuity, slitlamp examinations, tonometry, and corneal thickness were observed. Simulated keratometric and topographic index values were detected with corneal topography. Uncorrected, LogMAR visual acuity has improved from +0.8 to +0.55 during the 6 months and +0.3 during the 8 months follow-up after CXL. Pachymetry values and intraocular pressure showed no changes. Keratometric values and topografic indexes disclosed no progression of the disease. CXL may postpone or eliminate the need of corneal transplantation in cases with PMD.

Show MeSH
Related in: MedlinePlus