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Annular elastolytic giant cell granuloma of conjunctiva: a case report.

Konar K, Sanyal S, Rakshit A - Indian J Ophthalmol (2014)

Bottom Line: All the previous patients were females with lesions in nasal or temporal bulbar conjunctiva varying 2-3 mm in size.We report a male patient aged 70 years presenting with a 14 mm × 7 mm fleshy mass on right lower bulbar conjunctiva.Clinical differential diagnoses were lymphoma, squamous cell carcinoma in situ and amyloidosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Burdwan Medical College, Burdwan, West Bengal, India.

ABSTRACT
Annular elastolytic giant cell granuloma is a condition characterized histologically by damaged elastic fibers associated with preponderance of giant cells along with absence of necrobiosis, lipid, mucin, and pallisading granuloma. It usually occurs on sun-damaged skin and hence the previous name actinic granuloma. A similar process occurs on the conjunctiva. Over the past three decades only four cases of conjunctival actinic granuloma have been documented. All the previous patients were females with lesions in nasal or temporal bulbar conjunctiva varying 2-3 mm in size. We report a male patient aged 70 years presenting with a 14 mm × 7 mm fleshy mass on right lower bulbar conjunctiva. Clinical differential diagnoses were lymphoma, squamous cell carcinoma in situ and amyloidosis. Surgical excision followed by histopathology confirmed it to be a case of actinic granuloma. This is the first case of isolated conjunctival actinic granuloma of such a large size reported from India.

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Microphotograph showing the absence of elastic tissue in the centre of granuloma. Van Geison stain ×400
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Figure 4: Microphotograph showing the absence of elastic tissue in the centre of granuloma. Van Geison stain ×400

Mentions: The conjunctival mass was clinically diagnosed to be a squamous cell carcinoma in situ, lymphoma or amyloidosis. Excision biopsy followed by histopathological examination was done. Histopathology revealed a localized granulomatous inflammation with histiocytes around a homogeneous material along with giant cells and chronic inflammatory cells [Figs. 2 and 3]. Van Gieson and Congo red stains were performed. Congo red stain was negative. Van Gieson stain demonstrated the complete absence of elastic tissue at the center of the granuloma [Fig. 4].


Annular elastolytic giant cell granuloma of conjunctiva: a case report.

Konar K, Sanyal S, Rakshit A - Indian J Ophthalmol (2014)

Microphotograph showing the absence of elastic tissue in the centre of granuloma. Van Geison stain ×400
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061685&req=5

Figure 4: Microphotograph showing the absence of elastic tissue in the centre of granuloma. Van Geison stain ×400
Mentions: The conjunctival mass was clinically diagnosed to be a squamous cell carcinoma in situ, lymphoma or amyloidosis. Excision biopsy followed by histopathological examination was done. Histopathology revealed a localized granulomatous inflammation with histiocytes around a homogeneous material along with giant cells and chronic inflammatory cells [Figs. 2 and 3]. Van Gieson and Congo red stains were performed. Congo red stain was negative. Van Gieson stain demonstrated the complete absence of elastic tissue at the center of the granuloma [Fig. 4].

Bottom Line: All the previous patients were females with lesions in nasal or temporal bulbar conjunctiva varying 2-3 mm in size.We report a male patient aged 70 years presenting with a 14 mm × 7 mm fleshy mass on right lower bulbar conjunctiva.Clinical differential diagnoses were lymphoma, squamous cell carcinoma in situ and amyloidosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Burdwan Medical College, Burdwan, West Bengal, India.

ABSTRACT
Annular elastolytic giant cell granuloma is a condition characterized histologically by damaged elastic fibers associated with preponderance of giant cells along with absence of necrobiosis, lipid, mucin, and pallisading granuloma. It usually occurs on sun-damaged skin and hence the previous name actinic granuloma. A similar process occurs on the conjunctiva. Over the past three decades only four cases of conjunctival actinic granuloma have been documented. All the previous patients were females with lesions in nasal or temporal bulbar conjunctiva varying 2-3 mm in size. We report a male patient aged 70 years presenting with a 14 mm × 7 mm fleshy mass on right lower bulbar conjunctiva. Clinical differential diagnoses were lymphoma, squamous cell carcinoma in situ and amyloidosis. Surgical excision followed by histopathology confirmed it to be a case of actinic granuloma. This is the first case of isolated conjunctival actinic granuloma of such a large size reported from India.

Show MeSH
Related in: MedlinePlus