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Rhodotorula mucilaginosa Keratitis: a rare fungus from Eastern India.

Saha S, Sengupta J, Chatterjee D, Banerjee D - Indian J Ophthalmol (2014)

Bottom Line: Molecular identification of the organism was performed which showed 100% homology with Rhodotorula mucilaginosa.Management of these cases is difficult often necessitating surgical procedures.However further reports are necessary to understand the disease and establish a treatment protocol.

View Article: PubMed Central - PubMed

Affiliation: Ocular Microbiology Laboratory Services, Priyamvada Birla Aravind Eye Hospital, 10 Loudon Street, Kolkata; Department of Microbiology, Vidyasagar University, Midnapore, India.

ABSTRACT
Rhodotorula mucilaginosa rarely cause keratitis in immunocompromised individuals. A 30 year old male with history of minor trauma presented with cotton wool like stromal infiltration and hypopyon in left eye. Microbiological examination of corneal scraping showed fungal hyphae and yeast cells in direct smear. Molecular identification of the organism was performed which showed 100% homology with Rhodotorula mucilaginosa. Management of these cases is difficult often necessitating surgical procedures. However further reports are necessary to understand the disease and establish a treatment protocol.

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Gram stain image from corneal scraping showing mould hyphae and yeast
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Figure 2: Gram stain image from corneal scraping showing mould hyphae and yeast

Mentions: Standard microbiological workup was performed. 10% Potassium hydroxide (KOH) and Gram's staining showed mould hyphae and yeast [Fig. 2]. Topical treatment with Amphotericin B and natamycin 5% was started hourly along with atropine 1% eye drops used thrice a day. Systemic therapy consisted of oral itraconazole 100 mg twice daily. On medical therapy, there was progression of infiltrate necessitating a therapeutic keratoplasty with a 10 mm donor corneal button at 7 days from initial presentation. The excised corneal button was also subjected to microbiological and histopathological examination.


Rhodotorula mucilaginosa Keratitis: a rare fungus from Eastern India.

Saha S, Sengupta J, Chatterjee D, Banerjee D - Indian J Ophthalmol (2014)

Gram stain image from corneal scraping showing mould hyphae and yeast
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061676&req=5

Figure 2: Gram stain image from corneal scraping showing mould hyphae and yeast
Mentions: Standard microbiological workup was performed. 10% Potassium hydroxide (KOH) and Gram's staining showed mould hyphae and yeast [Fig. 2]. Topical treatment with Amphotericin B and natamycin 5% was started hourly along with atropine 1% eye drops used thrice a day. Systemic therapy consisted of oral itraconazole 100 mg twice daily. On medical therapy, there was progression of infiltrate necessitating a therapeutic keratoplasty with a 10 mm donor corneal button at 7 days from initial presentation. The excised corneal button was also subjected to microbiological and histopathological examination.

Bottom Line: Molecular identification of the organism was performed which showed 100% homology with Rhodotorula mucilaginosa.Management of these cases is difficult often necessitating surgical procedures.However further reports are necessary to understand the disease and establish a treatment protocol.

View Article: PubMed Central - PubMed

Affiliation: Ocular Microbiology Laboratory Services, Priyamvada Birla Aravind Eye Hospital, 10 Loudon Street, Kolkata; Department of Microbiology, Vidyasagar University, Midnapore, India.

ABSTRACT
Rhodotorula mucilaginosa rarely cause keratitis in immunocompromised individuals. A 30 year old male with history of minor trauma presented with cotton wool like stromal infiltration and hypopyon in left eye. Microbiological examination of corneal scraping showed fungal hyphae and yeast cells in direct smear. Molecular identification of the organism was performed which showed 100% homology with Rhodotorula mucilaginosa. Management of these cases is difficult often necessitating surgical procedures. However further reports are necessary to understand the disease and establish a treatment protocol.

Show MeSH
Related in: MedlinePlus