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Normative spectral domain optical coherence tomography data on macular and retinal nerve fiber layer thickness in Indians.

Appukuttan B, Giridhar A, Gopalakrishnan M, Sivaprasad S - Indian J Ophthalmol (2014)

Bottom Line: This data was compared with published literature on Caucasians to assess the ethnic variations of these parameters.The central foveal thickness showed a gender-based difference (P = 0.005) but did not correlate significantly with age (P = 0.134), whereas the parafoveal, perifoveal thickness, macular volume, and RNFL thickness showed significant negative correlation with age.It also suggests that age should be considered while interpreting the macular thickness and RNFL, whereas gender should also be given consideration in central foveal thickness.

View Article: PubMed Central - PubMed

Affiliation: Department of Vitreoretinal Services, Giridhar Eye Institute, Ponneth Temple Road, Kadavanthra, Cochin, Kerala, India.

ABSTRACT

Aim: To provide the normative data of macular and retinal nerve fiber layer (RNFL) thickness in Indians using spectral domain OCT (Spectralis OCT, Heidelberg Engineering, Germany) and to evaluate the effects of age, gender, and refraction on these parameters.

Design: Observational, cross-sectional study.

Materials and methods: The eyes of 105 healthy patients aged between 20-75 years, with no ocular disease and best corrected visual acuity of 20/20, were scanned using standard scanning protocols by a single examiner. Exclusion criteria included glaucoma, retinal diseases, diabetes, history of prior intraocular surgery or laser treatment. The mean macular and RNFL thickness were recorded, and the effects of age, gender, and refraction on these parameters were evaluated. This data was compared with published literature on Caucasians to assess the ethnic variations of these parameters.

Results: The normal central foveal thickness in healthy Indian eyes measured using Spectralis OCT was 260.1 ± 18.19 ΅m. The nasal inner quadrant showed maximum retinal thickness (338.88 ± 18.17 ΅m).The mean RNFL thickness was 101.43 ± 8.63 ΅m with maximum thickness in the inferior quadrant. The central foveal thickness showed a gender-based difference (P = 0.005) but did not correlate significantly with age (P = 0.134), whereas the parafoveal, perifoveal thickness, macular volume, and RNFL thickness showed significant negative correlation with age.

Conclusions: Our study provides the normative database for Indians on Spectralis OCT. It also suggests that age should be considered while interpreting the macular thickness and RNFL, whereas gender should also be given consideration in central foveal thickness.

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Related in: MedlinePlus

The standard ETDRS subfields dividing the macula into central fovea, inner macula, and outer macula. CFT: Central foveal thickness, SIM: Superior inner macula, NIM: Nasal inner macula, IIM: Inferior inner macula, TIM: Temporal inner macula, SOM: Superior outer macula, NOM: Nasal outer macula, IOM: Inferior outer macula, TOM: Temporal outer macula
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Figure 2: The standard ETDRS subfields dividing the macula into central fovea, inner macula, and outer macula. CFT: Central foveal thickness, SIM: Superior inner macula, NIM: Nasal inner macula, IIM: Inferior inner macula, TIM: Temporal inner macula, SOM: Superior outer macula, NOM: Nasal outer macula, IOM: Inferior outer macula, TOM: Temporal outer macula

Mentions: Each scan was individually reviewed, and segmentation lines were adjusted to ensure accuracy in both RNFL and macular thickness measurements. Macular thickness was reported in a modified Early Treatment of Diabetic Retinopathy Study macular map with the central subfield 1 mm in diameter and the inner and outer subfields having diameters of 3 mm and 6 mm, respectively [Figs. 1a and b]. The retinal thickness in the inner and outer subfields, the Central Foveal Thickness (CFT), the Center Point Thickness (CPT), and the macular volume were calculated.


Normative spectral domain optical coherence tomography data on macular and retinal nerve fiber layer thickness in Indians.

Appukuttan B, Giridhar A, Gopalakrishnan M, Sivaprasad S - Indian J Ophthalmol (2014)

The standard ETDRS subfields dividing the macula into central fovea, inner macula, and outer macula. CFT: Central foveal thickness, SIM: Superior inner macula, NIM: Nasal inner macula, IIM: Inferior inner macula, TIM: Temporal inner macula, SOM: Superior outer macula, NOM: Nasal outer macula, IOM: Inferior outer macula, TOM: Temporal outer macula
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061670&req=5

Figure 2: The standard ETDRS subfields dividing the macula into central fovea, inner macula, and outer macula. CFT: Central foveal thickness, SIM: Superior inner macula, NIM: Nasal inner macula, IIM: Inferior inner macula, TIM: Temporal inner macula, SOM: Superior outer macula, NOM: Nasal outer macula, IOM: Inferior outer macula, TOM: Temporal outer macula
Mentions: Each scan was individually reviewed, and segmentation lines were adjusted to ensure accuracy in both RNFL and macular thickness measurements. Macular thickness was reported in a modified Early Treatment of Diabetic Retinopathy Study macular map with the central subfield 1 mm in diameter and the inner and outer subfields having diameters of 3 mm and 6 mm, respectively [Figs. 1a and b]. The retinal thickness in the inner and outer subfields, the Central Foveal Thickness (CFT), the Center Point Thickness (CPT), and the macular volume were calculated.

Bottom Line: This data was compared with published literature on Caucasians to assess the ethnic variations of these parameters.The central foveal thickness showed a gender-based difference (P = 0.005) but did not correlate significantly with age (P = 0.134), whereas the parafoveal, perifoveal thickness, macular volume, and RNFL thickness showed significant negative correlation with age.It also suggests that age should be considered while interpreting the macular thickness and RNFL, whereas gender should also be given consideration in central foveal thickness.

View Article: PubMed Central - PubMed

Affiliation: Department of Vitreoretinal Services, Giridhar Eye Institute, Ponneth Temple Road, Kadavanthra, Cochin, Kerala, India.

ABSTRACT

Aim: To provide the normative data of macular and retinal nerve fiber layer (RNFL) thickness in Indians using spectral domain OCT (Spectralis OCT, Heidelberg Engineering, Germany) and to evaluate the effects of age, gender, and refraction on these parameters.

Design: Observational, cross-sectional study.

Materials and methods: The eyes of 105 healthy patients aged between 20-75 years, with no ocular disease and best corrected visual acuity of 20/20, were scanned using standard scanning protocols by a single examiner. Exclusion criteria included glaucoma, retinal diseases, diabetes, history of prior intraocular surgery or laser treatment. The mean macular and RNFL thickness were recorded, and the effects of age, gender, and refraction on these parameters were evaluated. This data was compared with published literature on Caucasians to assess the ethnic variations of these parameters.

Results: The normal central foveal thickness in healthy Indian eyes measured using Spectralis OCT was 260.1 ± 18.19 ΅m. The nasal inner quadrant showed maximum retinal thickness (338.88 ± 18.17 ΅m).The mean RNFL thickness was 101.43 ± 8.63 ΅m with maximum thickness in the inferior quadrant. The central foveal thickness showed a gender-based difference (P = 0.005) but did not correlate significantly with age (P = 0.134), whereas the parafoveal, perifoveal thickness, macular volume, and RNFL thickness showed significant negative correlation with age.

Conclusions: Our study provides the normative database for Indians on Spectralis OCT. It also suggests that age should be considered while interpreting the macular thickness and RNFL, whereas gender should also be given consideration in central foveal thickness.

Show MeSH
Related in: MedlinePlus