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Intraocular pressure and influencing systemic health parameters in a Korean population.

Han YS, Lee JW, Lee JS - Indian J Ophthalmol (2014)

Bottom Line: The mean IOP of men was significantly higher than women ( P = 0.000).By multiple linear regression analysis, IOP was positively associated with gender (male), BMI, total cholesterol, and TG and negatively associated with age ( P = 0.000).IOP was found to increase with total cholesterol, TG, BMI, and to decrease with only age regardless of sex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, College of Medicine, Pusan National University; Medical Research Institute, Pusan National University Hospital, Pusan, Korea.

ABSTRACT

Aim: To evaluate the relationship between intraocular pressure (IOP) and systemic health parameters such as age, gender, body mass index (BMI), total cholesterol, high density lipoprotein (HDL), and triglyceride (TG) in a Korean population.

Materials and methods: A total of 30,893 healthy subjects underwent automated multiphasic tests, including non-contact tonometry, automated perimetry, fundus photography, and blood samplings for total cholesterol, HDL, and TG. Seven age groups were divided by decades ranging from 20 to 29 years to 80 + years. The association between IOP and BMI, plasma lipid profiles was examined using cross-sectional analysis.

Results: The mean age of subjects was 47.7 years. The mean IOP of subjects was 15.4 ± 3.2 mmHg for both eyes. The mean IOP of men was significantly higher than women ( P = 0.000). By multiple linear regression analysis, IOP was positively associated with gender (male), BMI, total cholesterol, and TG and negatively associated with age ( P = 0.000). BMI, total cholesterol, and TG had significantly positive correlations with IOP after adjusting for age, gender, and other variables which can influence the IOP ( P = 0.000).

Conclusions: In a Korean population, the mean IOP, total cholesterol, TG, and BMI values of men were higher than women. IOP was found to increase with total cholesterol, TG, BMI, and to decrease with only age regardless of sex.

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Related in: MedlinePlus

Linear regression model of the BMI versus the IOP of the left eyes (BMI: Body mass index, IOP: Intraocular pressure)
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Figure 2: Linear regression model of the BMI versus the IOP of the left eyes (BMI: Body mass index, IOP: Intraocular pressure)

Mentions: The IOP had linear trends of increase with BMI, total cholesterol, and TG (Chi-square test for trend, P < 0.0001) [Tables 4–6]. However, IOP tended to decrease with increasing HDL (Chi-square test for trend, P < 0.0001) [Table 7]. A linear regression model showed that each kg/m2 of BMI resulted in an increase in IOP of 0.107 mmHg and 0.116 mmHg for right and left eyes, respectively (P = 0.000) [Figs. 1 and 2]. A linear regression model showed that each mg/dL of total cholesterol resulted in an increase in IOP of 0.008 mmHg and 0.009 mmHg for right and left eyes, respectively (P = 0.000) [Figs. 3 and 4]. A linear regression model showed that each mg/dL of TG resulted in an increase in IOP of 0.005 mmHg and 0.006 mmHg for right and left eyes, respectively (P = 0.000) [Figs. 5 and 6]. A linear regression model showed that each mg/dL of HDL resulted in a decrease in IOP of 0.016 mmHg and 0.017 mmHg for right and left eyes, respectively (P = 0.000) [Figs. 7 and 8].


Intraocular pressure and influencing systemic health parameters in a Korean population.

Han YS, Lee JW, Lee JS - Indian J Ophthalmol (2014)

Linear regression model of the BMI versus the IOP of the left eyes (BMI: Body mass index, IOP: Intraocular pressure)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061668&req=5

Figure 2: Linear regression model of the BMI versus the IOP of the left eyes (BMI: Body mass index, IOP: Intraocular pressure)
Mentions: The IOP had linear trends of increase with BMI, total cholesterol, and TG (Chi-square test for trend, P < 0.0001) [Tables 4–6]. However, IOP tended to decrease with increasing HDL (Chi-square test for trend, P < 0.0001) [Table 7]. A linear regression model showed that each kg/m2 of BMI resulted in an increase in IOP of 0.107 mmHg and 0.116 mmHg for right and left eyes, respectively (P = 0.000) [Figs. 1 and 2]. A linear regression model showed that each mg/dL of total cholesterol resulted in an increase in IOP of 0.008 mmHg and 0.009 mmHg for right and left eyes, respectively (P = 0.000) [Figs. 3 and 4]. A linear regression model showed that each mg/dL of TG resulted in an increase in IOP of 0.005 mmHg and 0.006 mmHg for right and left eyes, respectively (P = 0.000) [Figs. 5 and 6]. A linear regression model showed that each mg/dL of HDL resulted in a decrease in IOP of 0.016 mmHg and 0.017 mmHg for right and left eyes, respectively (P = 0.000) [Figs. 7 and 8].

Bottom Line: The mean IOP of men was significantly higher than women ( P = 0.000).By multiple linear regression analysis, IOP was positively associated with gender (male), BMI, total cholesterol, and TG and negatively associated with age ( P = 0.000).IOP was found to increase with total cholesterol, TG, BMI, and to decrease with only age regardless of sex.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, College of Medicine, Pusan National University; Medical Research Institute, Pusan National University Hospital, Pusan, Korea.

ABSTRACT

Aim: To evaluate the relationship between intraocular pressure (IOP) and systemic health parameters such as age, gender, body mass index (BMI), total cholesterol, high density lipoprotein (HDL), and triglyceride (TG) in a Korean population.

Materials and methods: A total of 30,893 healthy subjects underwent automated multiphasic tests, including non-contact tonometry, automated perimetry, fundus photography, and blood samplings for total cholesterol, HDL, and TG. Seven age groups were divided by decades ranging from 20 to 29 years to 80 + years. The association between IOP and BMI, plasma lipid profiles was examined using cross-sectional analysis.

Results: The mean age of subjects was 47.7 years. The mean IOP of subjects was 15.4 ± 3.2 mmHg for both eyes. The mean IOP of men was significantly higher than women ( P = 0.000). By multiple linear regression analysis, IOP was positively associated with gender (male), BMI, total cholesterol, and TG and negatively associated with age ( P = 0.000). BMI, total cholesterol, and TG had significantly positive correlations with IOP after adjusting for age, gender, and other variables which can influence the IOP ( P = 0.000).

Conclusions: In a Korean population, the mean IOP, total cholesterol, TG, and BMI values of men were higher than women. IOP was found to increase with total cholesterol, TG, BMI, and to decrease with only age regardless of sex.

Show MeSH
Related in: MedlinePlus