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Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema.

Zhu D, Zhu H, Wang C, Yang D - Indian J Ophthalmol (2014)

Bottom Line: Maximum height of submacular fluid measured by Optical coherence tomography (OCT) was significantly associated with aqueous sICAM-1 (r = -0.45, P = 0.034).The maximum height of macular thickness measured by OCT was not significantly associated with either VEGF (P = 0.300), MCP-1 (P = 0.320) or sICAM-1 (P = 0.285).Our results suggest that sICAM-1 may majorly contribute to the formation of subretinal fluid in DME patients and imply that MCP-1 and sICAM-1 may be the potential therapy targets, besides VEGF.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical College, Hohhot, Inner Mongolia, China.

ABSTRACT

Objective: To investigate the correlations between aqueous concentrations of vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), soluble intracellular adhesion molecule-1 (sICAM-1) and diabetic macular edema (DME).

Materials and methods: VEGF, MCP-1 and sICAM-1 concentrations in aqueous humor samples of 22 patients with DME and 23 patients with cataract of a control group were measured with solid-phase chemiluminescence immunoassay.

Results: Aqueous VEGF (89.2 ± 58.5 pg/ml versus 48.5 ± 27.8 pg/ml, P = 0.006), MCP-1 (684.2 ± 423.4 pg/ml versus 432.4 ± 230.4 pg/ml, P = 0.019) and sICAM-1 (3213.8 ± 2581.6 pg/ml versus 260.2 ± 212.2 pg/ml, P < 0.001) all vary significantly between DME group and control group. Maximum height of submacular fluid measured by Optical coherence tomography (OCT) was significantly associated with aqueous sICAM-1 (r = -0.45, P = 0.034). The maximum height of macular thickness measured by OCT was not significantly associated with either VEGF (P = 0.300), MCP-1 (P = 0.320) or sICAM-1 (P = 0.285).

Conclusions: Our results suggest that sICAM-1 may majorly contribute to the formation of subretinal fluid in DME patients and imply that MCP-1 and sICAM-1 may be the potential therapy targets, besides VEGF.

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Related in: MedlinePlus

Error bar showing the vascular endothelial growth factor in aqueous humor between cataract patients (n = 23) and diabetic macular edema patients (n = 22) (independent t-test, 48.5 ± 27.8 pg/ml versus 89.2 ± 58.5 pg/ml, P = 0.006)
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Figure 1: Error bar showing the vascular endothelial growth factor in aqueous humor between cataract patients (n = 23) and diabetic macular edema patients (n = 22) (independent t-test, 48.5 ± 27.8 pg/ml versus 89.2 ± 58.5 pg/ml, P = 0.006)

Mentions: Independent t-test showed that the aqueous VEGF vary significantly between DME group and control group (89.2 ± 58.5 pg/ml versus 48.5 ± 27.8 pg/ml, P = 0.006, Fig. 1). Similarly, aqueous MCP-1 (684.2 ± 423.4 pg/ml versus 432.4 ± 230.4 pg/ml, P = 0.019, Fig. 2) and sICAM-1 (3213.8 ± 2581.6 pg/ml versus 260.2 ± 212.2 pg/ml, P < 0.001, Fig. 3) also vary significantly between DME group and control group.


Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema.

Zhu D, Zhu H, Wang C, Yang D - Indian J Ophthalmol (2014)

Error bar showing the vascular endothelial growth factor in aqueous humor between cataract patients (n = 23) and diabetic macular edema patients (n = 22) (independent t-test, 48.5 ± 27.8 pg/ml versus 89.2 ± 58.5 pg/ml, P = 0.006)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061666&req=5

Figure 1: Error bar showing the vascular endothelial growth factor in aqueous humor between cataract patients (n = 23) and diabetic macular edema patients (n = 22) (independent t-test, 48.5 ± 27.8 pg/ml versus 89.2 ± 58.5 pg/ml, P = 0.006)
Mentions: Independent t-test showed that the aqueous VEGF vary significantly between DME group and control group (89.2 ± 58.5 pg/ml versus 48.5 ± 27.8 pg/ml, P = 0.006, Fig. 1). Similarly, aqueous MCP-1 (684.2 ± 423.4 pg/ml versus 432.4 ± 230.4 pg/ml, P = 0.019, Fig. 2) and sICAM-1 (3213.8 ± 2581.6 pg/ml versus 260.2 ± 212.2 pg/ml, P < 0.001, Fig. 3) also vary significantly between DME group and control group.

Bottom Line: Maximum height of submacular fluid measured by Optical coherence tomography (OCT) was significantly associated with aqueous sICAM-1 (r = -0.45, P = 0.034).The maximum height of macular thickness measured by OCT was not significantly associated with either VEGF (P = 0.300), MCP-1 (P = 0.320) or sICAM-1 (P = 0.285).Our results suggest that sICAM-1 may majorly contribute to the formation of subretinal fluid in DME patients and imply that MCP-1 and sICAM-1 may be the potential therapy targets, besides VEGF.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical College, Hohhot, Inner Mongolia, China.

ABSTRACT

Objective: To investigate the correlations between aqueous concentrations of vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), soluble intracellular adhesion molecule-1 (sICAM-1) and diabetic macular edema (DME).

Materials and methods: VEGF, MCP-1 and sICAM-1 concentrations in aqueous humor samples of 22 patients with DME and 23 patients with cataract of a control group were measured with solid-phase chemiluminescence immunoassay.

Results: Aqueous VEGF (89.2 ± 58.5 pg/ml versus 48.5 ± 27.8 pg/ml, P = 0.006), MCP-1 (684.2 ± 423.4 pg/ml versus 432.4 ± 230.4 pg/ml, P = 0.019) and sICAM-1 (3213.8 ± 2581.6 pg/ml versus 260.2 ± 212.2 pg/ml, P < 0.001) all vary significantly between DME group and control group. Maximum height of submacular fluid measured by Optical coherence tomography (OCT) was significantly associated with aqueous sICAM-1 (r = -0.45, P = 0.034). The maximum height of macular thickness measured by OCT was not significantly associated with either VEGF (P = 0.300), MCP-1 (P = 0.320) or sICAM-1 (P = 0.285).

Conclusions: Our results suggest that sICAM-1 may majorly contribute to the formation of subretinal fluid in DME patients and imply that MCP-1 and sICAM-1 may be the potential therapy targets, besides VEGF.

Show MeSH
Related in: MedlinePlus