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Hyperhomocysteinia is a risk factor for retinal venous occlusion: a case control study.

Al Wadani F, Khandekar R, Salim G, Al Ali M, Ramzi S - Indian J Ophthalmol (2014)

Bottom Line: A similar number of eyes without RVO were also examined.We included 20 cases of RVO and 20 age- and sex-matched persons without RVO.Any list of investigations for a case of RVO should include total plasma homocysteine (tHcy) levels.

View Article: PubMed Central - PubMed

Affiliation: Eye and Ear Health Care, Deaprtment of Non communicable Diseases control, Ministry of Health, Muscat, Oman.

ABSTRACT

Background: We evaluated the role of hyperhomocysteinemia as a risk factor for retinal vein occlusion (RVO) in Indian patients.

Type of study: Matched case control type of longitudinal study was conducted in 2006-2007.

Materials and methods: Two medical retina specialists examined the eyes having an event of RVO in the last 15 days. A similar number of eyes without RVO were also examined. The serum and urine homocysteine levels of these persons were tested. Matched pair analysis was carried out to determine the risk of RVO among those with hyperhomocysteinemia.

Results: We included 20 cases of RVO and 20 age- and sex-matched persons without RVO. The risk of RVO was significantly higher in persons with hyperhomocysteinemia [difference of mean 31.62 μmol/L (95% Confidence Interval 16.60-47 . 86), P = 2.1 × 10-13 ]. The mean urine homocysteine level among cases and controls was not statistically significant. There were 12 persons with hypertension in both cases and control groups.

Conclusion: Hyperhomocysteinemia is a risk factor for RVO. Any list of investigations for a case of RVO should include total plasma homocysteine (tHcy) levels.

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Related in: MedlinePlus

Histogram showing distribution of log values of serum homocysteine level in patients with retinal vein occlusion (cases) (n = 20, mean = 3.36, standard deviation = 0.45)
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Figure 1: Histogram showing distribution of log values of serum homocysteine level in patients with retinal vein occlusion (cases) (n = 20, mean = 3.36, standard deviation = 0.45)

Mentions: The serum homocysteine levels of patients with RVO did not show normal distribution. Therefore, we calculated the log values of serum levels of both cases and controls, and they showed normal distribution [Figs. 1 and 2]. The risk of RVO was significantly higher in persons with hyperhomocysteinemia [difference of mean 31.62 μmol/L (95% Confidence Interval or CI 16.60-47.86), P = 2.1 × 10−13]. We compared the results of our study with those of different case control studies [Table 1]. Hyperhomocysteinemia seems to be risk factor for RVO.


Hyperhomocysteinia is a risk factor for retinal venous occlusion: a case control study.

Al Wadani F, Khandekar R, Salim G, Al Ali M, Ramzi S - Indian J Ophthalmol (2014)

Histogram showing distribution of log values of serum homocysteine level in patients with retinal vein occlusion (cases) (n = 20, mean = 3.36, standard deviation = 0.45)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061665&req=5

Figure 1: Histogram showing distribution of log values of serum homocysteine level in patients with retinal vein occlusion (cases) (n = 20, mean = 3.36, standard deviation = 0.45)
Mentions: The serum homocysteine levels of patients with RVO did not show normal distribution. Therefore, we calculated the log values of serum levels of both cases and controls, and they showed normal distribution [Figs. 1 and 2]. The risk of RVO was significantly higher in persons with hyperhomocysteinemia [difference of mean 31.62 μmol/L (95% Confidence Interval or CI 16.60-47.86), P = 2.1 × 10−13]. We compared the results of our study with those of different case control studies [Table 1]. Hyperhomocysteinemia seems to be risk factor for RVO.

Bottom Line: A similar number of eyes without RVO were also examined.We included 20 cases of RVO and 20 age- and sex-matched persons without RVO.Any list of investigations for a case of RVO should include total plasma homocysteine (tHcy) levels.

View Article: PubMed Central - PubMed

Affiliation: Eye and Ear Health Care, Deaprtment of Non communicable Diseases control, Ministry of Health, Muscat, Oman.

ABSTRACT

Background: We evaluated the role of hyperhomocysteinemia as a risk factor for retinal vein occlusion (RVO) in Indian patients.

Type of study: Matched case control type of longitudinal study was conducted in 2006-2007.

Materials and methods: Two medical retina specialists examined the eyes having an event of RVO in the last 15 days. A similar number of eyes without RVO were also examined. The serum and urine homocysteine levels of these persons were tested. Matched pair analysis was carried out to determine the risk of RVO among those with hyperhomocysteinemia.

Results: We included 20 cases of RVO and 20 age- and sex-matched persons without RVO. The risk of RVO was significantly higher in persons with hyperhomocysteinemia [difference of mean 31.62 μmol/L (95% Confidence Interval 16.60-47 . 86), P = 2.1 × 10-13 ]. The mean urine homocysteine level among cases and controls was not statistically significant. There were 12 persons with hypertension in both cases and control groups.

Conclusion: Hyperhomocysteinemia is a risk factor for RVO. Any list of investigations for a case of RVO should include total plasma homocysteine (tHcy) levels.

Show MeSH
Related in: MedlinePlus