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Evaluation of anti-diabetic activity of Glucova Active Tablet on Type I and Type II diabetic model in rats.

Soni H, Patel S, Patel G, Paranjape A - J Ayurveda Integr Med (2014)

Bottom Line: Glucova Active Tablet showed significant effect on fasting blood glucose level.It also showed significant alteration in lipid profile and antioxidant parameters.It was also found showing good anti-hyperlipidemic activity and anti-oxidant property.

View Article: PubMed Central - PubMed

Affiliation: Vasu Research Centre, A Division of Vasu Healthcare Pvt. Ltd., G.I.D.C., Makarpura, India.

ABSTRACT

Background: Glucova Active Tablet is a proprietary Ayurvedic formulation with ingredients reported for anti-hyperglycemic, anti-hyperlipidemic activity and antioxidant properties.

Objective: Evaluation of anti-diabetic activity of Glucova Active Tablet on Type I and Type II diabetic model in rats.

Materials and methods: Experimental Type I diabetes was induced in 24 albino rats with intra-peritoneal injection of streptozotocin (50 mg/kg). Type II diabetes was induced in 18 albino rats by intra-peritoneal injection of streptozotocin (35 mg/kg) along with high fat diet. The rats were divided in 5 groups for Type I model and 4 groups for Type II model. Normal control group was kept common for both experimental models. Glucova Active Tablet (108 mg/kg) treatment was provided for 28 days twice daily orally. Fasting blood glucose level, serum lipid profile and liver anti-oxidant parameters like superoxide dismutase and reduced glutathione was carried out in both experimental models. Pancreas histopathology was also done. Statistical analysis were done by 'analysis of variance' test followed by post hoc Tukey's test, with significant level of P < 0.05.

Results and discussion: Glucova Active Tablet showed significant effect on fasting blood glucose level. It also showed significant alteration in lipid profile and antioxidant parameters. Histopathology study revealed restoration of beta cells in pancreas in Glucova Active Tablet treated group.

Conclusion: Finding of this study concludes that Glucova Active Tablet has shown promising anti-diabetic activity in Type I and Type II diabetic rats. It was also found showing good anti-hyperlipidemic activity and anti-oxidant property.

No MeSH data available.


Related in: MedlinePlus

Histopathological pictures of pancreas of Type I diabetes. (a) Diabetic control, beta cell destruction as indicate by arrow; (b) Glucova Active Tablet treated, showing recovery of pancreatic beta cell destruction as indicate by arrow; (c) Metformin treated, showing recovery of pancreatic beta cell destruction as indicate by arrow; (d) Insulin treated, showing minor recovery of pancreatic beta cell destruction as indicate by arrow
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Figure 1: Histopathological pictures of pancreas of Type I diabetes. (a) Diabetic control, beta cell destruction as indicate by arrow; (b) Glucova Active Tablet treated, showing recovery of pancreatic beta cell destruction as indicate by arrow; (c) Metformin treated, showing recovery of pancreatic beta cell destruction as indicate by arrow; (d) Insulin treated, showing minor recovery of pancreatic beta cell destruction as indicate by arrow

Mentions: Histopathology of pancreas of normal control rat showed normal cytoarchitecture of pancreatic cells [Figure 2a]. The impact of treatment of Glucova Active Tablet on the structure of the beta cells of pancreas was studied as compared to the disease control group of representative model for Type I [Figure 1a] and Type II [Figure 2b] diabetes. Glucova Active Tablet treated groups showed improvement in pancreatic islets cell histopathology in both Type I [Figure 1b] and Type II [Figure 2c] experimental models. Reference standard drug treated groups for Type I diabetic model i.e., Metformin treated [Figure 1c] and Insulin treated [Figure 1d] showed significant recovery. In Type II diabetic model reference standard metformin-treated group [Figure 2d] also showed similar recovery like Type I diabetic model.


Evaluation of anti-diabetic activity of Glucova Active Tablet on Type I and Type II diabetic model in rats.

Soni H, Patel S, Patel G, Paranjape A - J Ayurveda Integr Med (2014)

Histopathological pictures of pancreas of Type I diabetes. (a) Diabetic control, beta cell destruction as indicate by arrow; (b) Glucova Active Tablet treated, showing recovery of pancreatic beta cell destruction as indicate by arrow; (c) Metformin treated, showing recovery of pancreatic beta cell destruction as indicate by arrow; (d) Insulin treated, showing minor recovery of pancreatic beta cell destruction as indicate by arrow
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061597&req=5

Figure 1: Histopathological pictures of pancreas of Type I diabetes. (a) Diabetic control, beta cell destruction as indicate by arrow; (b) Glucova Active Tablet treated, showing recovery of pancreatic beta cell destruction as indicate by arrow; (c) Metformin treated, showing recovery of pancreatic beta cell destruction as indicate by arrow; (d) Insulin treated, showing minor recovery of pancreatic beta cell destruction as indicate by arrow
Mentions: Histopathology of pancreas of normal control rat showed normal cytoarchitecture of pancreatic cells [Figure 2a]. The impact of treatment of Glucova Active Tablet on the structure of the beta cells of pancreas was studied as compared to the disease control group of representative model for Type I [Figure 1a] and Type II [Figure 2b] diabetes. Glucova Active Tablet treated groups showed improvement in pancreatic islets cell histopathology in both Type I [Figure 1b] and Type II [Figure 2c] experimental models. Reference standard drug treated groups for Type I diabetic model i.e., Metformin treated [Figure 1c] and Insulin treated [Figure 1d] showed significant recovery. In Type II diabetic model reference standard metformin-treated group [Figure 2d] also showed similar recovery like Type I diabetic model.

Bottom Line: Glucova Active Tablet showed significant effect on fasting blood glucose level.It also showed significant alteration in lipid profile and antioxidant parameters.It was also found showing good anti-hyperlipidemic activity and anti-oxidant property.

View Article: PubMed Central - PubMed

Affiliation: Vasu Research Centre, A Division of Vasu Healthcare Pvt. Ltd., G.I.D.C., Makarpura, India.

ABSTRACT

Background: Glucova Active Tablet is a proprietary Ayurvedic formulation with ingredients reported for anti-hyperglycemic, anti-hyperlipidemic activity and antioxidant properties.

Objective: Evaluation of anti-diabetic activity of Glucova Active Tablet on Type I and Type II diabetic model in rats.

Materials and methods: Experimental Type I diabetes was induced in 24 albino rats with intra-peritoneal injection of streptozotocin (50 mg/kg). Type II diabetes was induced in 18 albino rats by intra-peritoneal injection of streptozotocin (35 mg/kg) along with high fat diet. The rats were divided in 5 groups for Type I model and 4 groups for Type II model. Normal control group was kept common for both experimental models. Glucova Active Tablet (108 mg/kg) treatment was provided for 28 days twice daily orally. Fasting blood glucose level, serum lipid profile and liver anti-oxidant parameters like superoxide dismutase and reduced glutathione was carried out in both experimental models. Pancreas histopathology was also done. Statistical analysis were done by 'analysis of variance' test followed by post hoc Tukey's test, with significant level of P < 0.05.

Results and discussion: Glucova Active Tablet showed significant effect on fasting blood glucose level. It also showed significant alteration in lipid profile and antioxidant parameters. Histopathology study revealed restoration of beta cells in pancreas in Glucova Active Tablet treated group.

Conclusion: Finding of this study concludes that Glucova Active Tablet has shown promising anti-diabetic activity in Type I and Type II diabetic rats. It was also found showing good anti-hyperlipidemic activity and anti-oxidant property.

No MeSH data available.


Related in: MedlinePlus