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Does copper enhance the antihypertensive effect of Elaeocarpus ganitrus in experimentally induced hypertensive rats?

Barve KH, Chodankar R - J Ayurveda Integr Med (2014)

Bottom Line: E1 and E2 did not show any toxicity at the dose of 5 g/kg in rats.It was found that 15 mg/kg of E1 and 30 mg/kg of E2 decreases the blood pressure by 30.20 mmHg and 28.96 mmHg, respectively, in hypertensive rats.Copper ions in E1 might be additively affecting the reduction in blood pressure with the usage of Elaeocarpus ganitrus extracts.

View Article: PubMed Central - PubMed

Affiliation: Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Department of Pharmacognosy, Shri VileParle Kelavani Manlal's Narsee Monjee Institute of Management Studies, Mumbai, Maharashtra, India.

ABSTRACT
Ayurveda, one of the traditional systems of medicine of India, reports that the seeds of Elaeocarpus ganitrus Linn. (Tilaceae) can be used for the treatment of hypertension. The main aim is to evaluate the antihypertensive effect of Elaeocarpus ganitrus (Rudraksha) seeds. Powdered seeds were extracted by maceration, overnight, using water, in copper (E1) and glass vessel (E2) and analyzed for antihypertensive activity in cadmium chloride (1 mg/kg intraperitoneally, for a period of 15 days) induced hypertensive male Wistar rats at three dose levels. E1 was administered at the dose of 5, 10, and 15 mg/kg and E2 at dose of 10, 20, and 30 mg/kg. All the data were analyzed using one way analysis of variance (ANOVA) followed by Dunnett's multiple comparison test. E1 and E2 did not show any toxicity at the dose of 5 g/kg in rats. It was found that 15 mg/kg of E1 and 30 mg/kg of E2 decreases the blood pressure by 30.20 mmHg and 28.96 mmHg, respectively, in hypertensive rats. Thus, it can be said that 15 mg/kg of E1 produced similar decrease in blood pressure as was observed with 30 mg/kg of E2. Copper ions in E1 might be additively affecting the reduction in blood pressure with the usage of Elaeocarpus ganitrus extracts.

No MeSH data available.


Related in: MedlinePlus

Effect of E1 and E2 on normotensive animals. Each values represent Mean ± S.E.M. for the number of animals utilized during experiment. ***P<0.001, when compare to normal control animals. Actual figures from which graph i drawn Normal control: 103.66±4.13, E1 5: 95.5±0.85, E1 10: 85.15±1.08, E1 15: 70.11±0.83, E2 10: 86.15±1.5, E2 20: 74.18±1.19, E2 30: 64.6±1.35
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Figure 4: Effect of E1 and E2 on normotensive animals. Each values represent Mean ± S.E.M. for the number of animals utilized during experiment. ***P<0.001, when compare to normal control animals. Actual figures from which graph i drawn Normal control: 103.66±4.13, E1 5: 95.5±0.85, E1 10: 85.15±1.08, E1 15: 70.11±0.83, E2 10: 86.15±1.5, E2 20: 74.18±1.19, E2 30: 64.6±1.35

Mentions: Extracts E1 and E2 show considerable and significant effect on the blood pressure of normotensive animals [Figure 2] and hypertensive animals [Figure 3]. Further it was observed that the decrement in blood pressure is same for 10 and 15 mg/kg dose of E1 and 20 and 30 mg/kg dose of E2. Administration of vehicles did not show significant change in the blood pressure of either group.


Does copper enhance the antihypertensive effect of Elaeocarpus ganitrus in experimentally induced hypertensive rats?

Barve KH, Chodankar R - J Ayurveda Integr Med (2014)

Effect of E1 and E2 on normotensive animals. Each values represent Mean ± S.E.M. for the number of animals utilized during experiment. ***P<0.001, when compare to normal control animals. Actual figures from which graph i drawn Normal control: 103.66±4.13, E1 5: 95.5±0.85, E1 10: 85.15±1.08, E1 15: 70.11±0.83, E2 10: 86.15±1.5, E2 20: 74.18±1.19, E2 30: 64.6±1.35
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061593&req=5

Figure 4: Effect of E1 and E2 on normotensive animals. Each values represent Mean ± S.E.M. for the number of animals utilized during experiment. ***P<0.001, when compare to normal control animals. Actual figures from which graph i drawn Normal control: 103.66±4.13, E1 5: 95.5±0.85, E1 10: 85.15±1.08, E1 15: 70.11±0.83, E2 10: 86.15±1.5, E2 20: 74.18±1.19, E2 30: 64.6±1.35
Mentions: Extracts E1 and E2 show considerable and significant effect on the blood pressure of normotensive animals [Figure 2] and hypertensive animals [Figure 3]. Further it was observed that the decrement in blood pressure is same for 10 and 15 mg/kg dose of E1 and 20 and 30 mg/kg dose of E2. Administration of vehicles did not show significant change in the blood pressure of either group.

Bottom Line: E1 and E2 did not show any toxicity at the dose of 5 g/kg in rats.It was found that 15 mg/kg of E1 and 30 mg/kg of E2 decreases the blood pressure by 30.20 mmHg and 28.96 mmHg, respectively, in hypertensive rats.Copper ions in E1 might be additively affecting the reduction in blood pressure with the usage of Elaeocarpus ganitrus extracts.

View Article: PubMed Central - PubMed

Affiliation: Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Department of Pharmacognosy, Shri VileParle Kelavani Manlal's Narsee Monjee Institute of Management Studies, Mumbai, Maharashtra, India.

ABSTRACT
Ayurveda, one of the traditional systems of medicine of India, reports that the seeds of Elaeocarpus ganitrus Linn. (Tilaceae) can be used for the treatment of hypertension. The main aim is to evaluate the antihypertensive effect of Elaeocarpus ganitrus (Rudraksha) seeds. Powdered seeds were extracted by maceration, overnight, using water, in copper (E1) and glass vessel (E2) and analyzed for antihypertensive activity in cadmium chloride (1 mg/kg intraperitoneally, for a period of 15 days) induced hypertensive male Wistar rats at three dose levels. E1 was administered at the dose of 5, 10, and 15 mg/kg and E2 at dose of 10, 20, and 30 mg/kg. All the data were analyzed using one way analysis of variance (ANOVA) followed by Dunnett's multiple comparison test. E1 and E2 did not show any toxicity at the dose of 5 g/kg in rats. It was found that 15 mg/kg of E1 and 30 mg/kg of E2 decreases the blood pressure by 30.20 mmHg and 28.96 mmHg, respectively, in hypertensive rats. Thus, it can be said that 15 mg/kg of E1 produced similar decrease in blood pressure as was observed with 30 mg/kg of E2. Copper ions in E1 might be additively affecting the reduction in blood pressure with the usage of Elaeocarpus ganitrus extracts.

No MeSH data available.


Related in: MedlinePlus