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Does copper enhance the antihypertensive effect of Elaeocarpus ganitrus in experimentally induced hypertensive rats?

Barve KH, Chodankar R - J Ayurveda Integr Med (2014)

Bottom Line: E1 and E2 did not show any toxicity at the dose of 5 g/kg in rats.It was found that 15 mg/kg of E1 and 30 mg/kg of E2 decreases the blood pressure by 30.20 mmHg and 28.96 mmHg, respectively, in hypertensive rats.Thus, it can be said that 15 mg/kg of E1 produced similar decrease in blood pressure as was observed with 30 mg/kg of E2.

View Article: PubMed Central - PubMed

Affiliation: Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Department of Pharmacognosy, Shri VileParle Kelavani Manlal's Narsee Monjee Institute of Management Studies, Mumbai, Maharashtra, India.

ABSTRACT
Ayurveda, one of the traditional systems of medicine of India, reports that the seeds of Elaeocarpus ganitrus Linn. (Tilaceae) can be used for the treatment of hypertension. The main aim is to evaluate the antihypertensive effect of Elaeocarpus ganitrus (Rudraksha) seeds. Powdered seeds were extracted by maceration, overnight, using water, in copper (E1) and glass vessel (E2) and analyzed for antihypertensive activity in cadmium chloride (1 mg/kg intraperitoneally, for a period of 15 days) induced hypertensive male Wistar rats at three dose levels. E1 was administered at the dose of 5, 10, and 15 mg/kg and E2 at dose of 10, 20, and 30 mg/kg. All the data were analyzed using one way analysis of variance (ANOVA) followed by Dunnett's multiple comparison test. E1 and E2 did not show any toxicity at the dose of 5 g/kg in rats. It was found that 15 mg/kg of E1 and 30 mg/kg of E2 decreases the blood pressure by 30.20 mmHg and 28.96 mmHg, respectively, in hypertensive rats. Thus, it can be said that 15 mg/kg of E1 produced similar decrease in blood pressure as was observed with 30 mg/kg of E2. Copper ions in E1 might be additively affecting the reduction in blood pressure with the usage of Elaeocarpus ganitrus extracts.

No MeSH data available.


Related in: MedlinePlus

Division of experimental animals
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Figure 1: Division of experimental animals

Mentions: Experimental animals were divided as shown in the Graph 1 below. Hypertension was induced in the animals by intraperitoneal injection of cadmium chloride at dose of 1 mg/kg for a period of 15 days.[12] The acute effect on mean arterial blood pressure was observed for a period of 15 min at each dose level, using the invasive blood pressure monitoring system (Iworks data recorder). All the animals of both groups also received normal water and water kept in copper vessel to observe the effect of vehicle on blood pressure.


Does copper enhance the antihypertensive effect of Elaeocarpus ganitrus in experimentally induced hypertensive rats?

Barve KH, Chodankar R - J Ayurveda Integr Med (2014)

Division of experimental animals
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061593&req=5

Figure 1: Division of experimental animals
Mentions: Experimental animals were divided as shown in the Graph 1 below. Hypertension was induced in the animals by intraperitoneal injection of cadmium chloride at dose of 1 mg/kg for a period of 15 days.[12] The acute effect on mean arterial blood pressure was observed for a period of 15 min at each dose level, using the invasive blood pressure monitoring system (Iworks data recorder). All the animals of both groups also received normal water and water kept in copper vessel to observe the effect of vehicle on blood pressure.

Bottom Line: E1 and E2 did not show any toxicity at the dose of 5 g/kg in rats.It was found that 15 mg/kg of E1 and 30 mg/kg of E2 decreases the blood pressure by 30.20 mmHg and 28.96 mmHg, respectively, in hypertensive rats.Thus, it can be said that 15 mg/kg of E1 produced similar decrease in blood pressure as was observed with 30 mg/kg of E2.

View Article: PubMed Central - PubMed

Affiliation: Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Department of Pharmacognosy, Shri VileParle Kelavani Manlal's Narsee Monjee Institute of Management Studies, Mumbai, Maharashtra, India.

ABSTRACT
Ayurveda, one of the traditional systems of medicine of India, reports that the seeds of Elaeocarpus ganitrus Linn. (Tilaceae) can be used for the treatment of hypertension. The main aim is to evaluate the antihypertensive effect of Elaeocarpus ganitrus (Rudraksha) seeds. Powdered seeds were extracted by maceration, overnight, using water, in copper (E1) and glass vessel (E2) and analyzed for antihypertensive activity in cadmium chloride (1 mg/kg intraperitoneally, for a period of 15 days) induced hypertensive male Wistar rats at three dose levels. E1 was administered at the dose of 5, 10, and 15 mg/kg and E2 at dose of 10, 20, and 30 mg/kg. All the data were analyzed using one way analysis of variance (ANOVA) followed by Dunnett's multiple comparison test. E1 and E2 did not show any toxicity at the dose of 5 g/kg in rats. It was found that 15 mg/kg of E1 and 30 mg/kg of E2 decreases the blood pressure by 30.20 mmHg and 28.96 mmHg, respectively, in hypertensive rats. Thus, it can be said that 15 mg/kg of E1 produced similar decrease in blood pressure as was observed with 30 mg/kg of E2. Copper ions in E1 might be additively affecting the reduction in blood pressure with the usage of Elaeocarpus ganitrus extracts.

No MeSH data available.


Related in: MedlinePlus