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Efficacy of a standardized herbal preparation (Roidosanal(®)) in the treatment of hemorrhoids: A randomized, controlled, open-label multicentre study.

Aggrawal K, Satija N, Dasgupta G, Dasgupta P, Nain P, Sahu AR - J Ayurveda Integr Med (2014)

Bottom Line: Baseline characteristics were comparable between the two groups.Hemorrhoids associated symptoms like bleeding, pain, etc., improved in both groups, although intergroup comparisons were comparable.Roidosanal(®) can be tried as a safe and effective treatment option for treatment of hemorrhoids.

View Article: PubMed Central - PubMed

Affiliation: General and Laparoscopy Surgery, Mohinder Hospital, Green Park, New Delhi, India.

ABSTRACT

Background: Catechins and epicatechins are monomers of naturally occurring proanthocyanidins, which have been reported with free radical scavenging, antioxidant, antiinflammatory, antiallergic, and vasodilatory properties. Plant parts rich in proanthocyanidins have been used for years in treatment of various ano-rectal diseases. This study compares the efficacy of two herbal preparations, Daflon(®) 500 mg and Roidosanal(®), in ameliorating the signs and symptoms associated with hemorrhoids.

Objective: To evaluate the safety and to compare the efficacy of a herbal preparation, Roidosanal(®) versus Daflon(®) 500 mg, on signs and symptoms of hemorrhoidal disease.

Materials and methods: In this pilot, active controlled, open-labeled multicentre study, 73 patients with proctoscopy proven hemorrhoids (Grade I to III) were randomly assigned to receive either Roidosanal(®) (Gr R; n = 37) or Daflon(®) 500 mg (Gr D; n = 36), for 15 days, at three centers in India. Assessment of hemorrhoidal symptoms was carried out in all patients at different time points. Intent-to-treat analysis was performed for both primary and secondary endpoints.

Results: Baseline characteristics were comparable between the two groups. Both products were found to be equally effective in improving the ano-rectal conditions in Grade I and Grade II hemorrhoids; however, Roidosanal(®) demonstrated better efficacy in patients with Grade III hemorrhoids. Hemorrhoids associated symptoms like bleeding, pain, etc., improved in both groups, although intergroup comparisons were comparable.

Conclusion: Both Roidosanal(®) and Daflon(®) 500 mg were equally effective in resolving signs and symptoms of hemorrhoids. Roidosanal(®) can be tried as a safe and effective treatment option for treatment of hemorrhoids. Further randomized, double-blind and large multicentre studies are recommended.

No MeSH data available.


Related in: MedlinePlus

Distribution of patients with pain symptom at baseline and at follow-ups. Within group differences as depicted above were compared using Pearson chi-square test. Between group differences (Roidosanal® vs Daflon® at all visits were comparable (Pearson chi-square test; Day 0, P = 0.577; Day 8, P = 0.408; Day 16, P = 0.765; Day 45, P = 0.751)
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Figure 3: Distribution of patients with pain symptom at baseline and at follow-ups. Within group differences as depicted above were compared using Pearson chi-square test. Between group differences (Roidosanal® vs Daflon® at all visits were comparable (Pearson chi-square test; Day 0, P = 0.577; Day 8, P = 0.408; Day 16, P = 0.765; Day 45, P = 0.751)

Mentions: There was significant decrease in severity and frequency of ano-rectal pain in both groups on Days 8, 16, and 45 [Figure 3 and Table 3]. The intergroup analysis was comparable as both products demonstrated similar efficacy in relieving severity and frequency of pain on 8th, 16th, and 45th day [Figure 3 and Table 3].


Efficacy of a standardized herbal preparation (Roidosanal(®)) in the treatment of hemorrhoids: A randomized, controlled, open-label multicentre study.

Aggrawal K, Satija N, Dasgupta G, Dasgupta P, Nain P, Sahu AR - J Ayurveda Integr Med (2014)

Distribution of patients with pain symptom at baseline and at follow-ups. Within group differences as depicted above were compared using Pearson chi-square test. Between group differences (Roidosanal® vs Daflon® at all visits were comparable (Pearson chi-square test; Day 0, P = 0.577; Day 8, P = 0.408; Day 16, P = 0.765; Day 45, P = 0.751)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061586&req=5

Figure 3: Distribution of patients with pain symptom at baseline and at follow-ups. Within group differences as depicted above were compared using Pearson chi-square test. Between group differences (Roidosanal® vs Daflon® at all visits were comparable (Pearson chi-square test; Day 0, P = 0.577; Day 8, P = 0.408; Day 16, P = 0.765; Day 45, P = 0.751)
Mentions: There was significant decrease in severity and frequency of ano-rectal pain in both groups on Days 8, 16, and 45 [Figure 3 and Table 3]. The intergroup analysis was comparable as both products demonstrated similar efficacy in relieving severity and frequency of pain on 8th, 16th, and 45th day [Figure 3 and Table 3].

Bottom Line: Baseline characteristics were comparable between the two groups.Hemorrhoids associated symptoms like bleeding, pain, etc., improved in both groups, although intergroup comparisons were comparable.Roidosanal(®) can be tried as a safe and effective treatment option for treatment of hemorrhoids.

View Article: PubMed Central - PubMed

Affiliation: General and Laparoscopy Surgery, Mohinder Hospital, Green Park, New Delhi, India.

ABSTRACT

Background: Catechins and epicatechins are monomers of naturally occurring proanthocyanidins, which have been reported with free radical scavenging, antioxidant, antiinflammatory, antiallergic, and vasodilatory properties. Plant parts rich in proanthocyanidins have been used for years in treatment of various ano-rectal diseases. This study compares the efficacy of two herbal preparations, Daflon(®) 500 mg and Roidosanal(®), in ameliorating the signs and symptoms associated with hemorrhoids.

Objective: To evaluate the safety and to compare the efficacy of a herbal preparation, Roidosanal(®) versus Daflon(®) 500 mg, on signs and symptoms of hemorrhoidal disease.

Materials and methods: In this pilot, active controlled, open-labeled multicentre study, 73 patients with proctoscopy proven hemorrhoids (Grade I to III) were randomly assigned to receive either Roidosanal(®) (Gr R; n = 37) or Daflon(®) 500 mg (Gr D; n = 36), for 15 days, at three centers in India. Assessment of hemorrhoidal symptoms was carried out in all patients at different time points. Intent-to-treat analysis was performed for both primary and secondary endpoints.

Results: Baseline characteristics were comparable between the two groups. Both products were found to be equally effective in improving the ano-rectal conditions in Grade I and Grade II hemorrhoids; however, Roidosanal(®) demonstrated better efficacy in patients with Grade III hemorrhoids. Hemorrhoids associated symptoms like bleeding, pain, etc., improved in both groups, although intergroup comparisons were comparable.

Conclusion: Both Roidosanal(®) and Daflon(®) 500 mg were equally effective in resolving signs and symptoms of hemorrhoids. Roidosanal(®) can be tried as a safe and effective treatment option for treatment of hemorrhoids. Further randomized, double-blind and large multicentre studies are recommended.

No MeSH data available.


Related in: MedlinePlus