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Phase-contrast X-ray CT imaging of esophagus and esophageal carcinoma.

Zhang J, Tian D, Lin R, Zhou G, Peng G, Su M - Sci Rep (2014)

Bottom Line: The surface of the mucous layer was smooth.The boundary between normal tissue and tumor was comparatively fuzzy, the three-layer structure of the esophageal wall was indistinct.The surface of the mucous layer was rugose.

View Article: PubMed Central - PubMed

Affiliation: First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People's Republic of China.

ABSTRACT
The electron density resolution is 1000 times higher for synchrotron-radiation phase-contrast CT imaging than conventional X-ray absorption imaging in light elements, with which high-resolution X-ray imaging of biological soft tissue can be achieved. In the present study, we used phase-contrast X-ray CT to investigate human resected esophagus and esophageal carcinoma specimens. This technology revealed the three-layer structure of the esophageal wall-- mucous, submucosa and muscular layers. The mucous and muscular layers were clearly separated by a loose submucosa layer with a honeycomb appearance. The surface of the mucous layer was smooth. In esophageal carcinoma, because of tumor tissue infiltration, the submucosa layer was absent, which indicated destruction of the submucosa. The boundary between normal tissue and tumor was comparatively fuzzy, the three-layer structure of the esophageal wall was indistinct. The surface of the mucous layer was rugose. The technology might be helpful in tumor staging of esophageal carcinoma.

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Resected human esophagus and esophageal carcinoma specimens.Yellow arrow is tumor.
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f6: Resected human esophagus and esophageal carcinoma specimens.Yellow arrow is tumor.

Mentions: Phase-contrast X-ray CT revealed the esophageal carcinoma specimen as cancerous tissue infiltrating the entire esophageal wall. The subtotal submucosa layer was absent, and the boundary between tumor tissues and a normal esophageal wall was comparatively fuzzy (Figure 4). The esophageal wall became irregularly shaped, and the mucosa surface became rugose. In this esophageal carcinoma specimen, the muscular layer was not penetrated, so the surface of muscular layer remained smooth (Figure 5). Figure 6 shows a human resected esophagus and esophageal carcinoma specimens. The tissue shows many cancer nests, evidenced by round or oval low-density areas due to necrosis (Figure 7). Additional carcinoma tissue images are shown in Figure 8, showing mucosal destruction and intraluminal filling defects. CT revealed an incrassate esophageal wall. However, the 2 modalities could not discriminate tumor infiltration depth in the esophageal wall.


Phase-contrast X-ray CT imaging of esophagus and esophageal carcinoma.

Zhang J, Tian D, Lin R, Zhou G, Peng G, Su M - Sci Rep (2014)

Resected human esophagus and esophageal carcinoma specimens.Yellow arrow is tumor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061548&req=5

f6: Resected human esophagus and esophageal carcinoma specimens.Yellow arrow is tumor.
Mentions: Phase-contrast X-ray CT revealed the esophageal carcinoma specimen as cancerous tissue infiltrating the entire esophageal wall. The subtotal submucosa layer was absent, and the boundary between tumor tissues and a normal esophageal wall was comparatively fuzzy (Figure 4). The esophageal wall became irregularly shaped, and the mucosa surface became rugose. In this esophageal carcinoma specimen, the muscular layer was not penetrated, so the surface of muscular layer remained smooth (Figure 5). Figure 6 shows a human resected esophagus and esophageal carcinoma specimens. The tissue shows many cancer nests, evidenced by round or oval low-density areas due to necrosis (Figure 7). Additional carcinoma tissue images are shown in Figure 8, showing mucosal destruction and intraluminal filling defects. CT revealed an incrassate esophageal wall. However, the 2 modalities could not discriminate tumor infiltration depth in the esophageal wall.

Bottom Line: The surface of the mucous layer was smooth.The boundary between normal tissue and tumor was comparatively fuzzy, the three-layer structure of the esophageal wall was indistinct.The surface of the mucous layer was rugose.

View Article: PubMed Central - PubMed

Affiliation: First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People's Republic of China.

ABSTRACT
The electron density resolution is 1000 times higher for synchrotron-radiation phase-contrast CT imaging than conventional X-ray absorption imaging in light elements, with which high-resolution X-ray imaging of biological soft tissue can be achieved. In the present study, we used phase-contrast X-ray CT to investigate human resected esophagus and esophageal carcinoma specimens. This technology revealed the three-layer structure of the esophageal wall-- mucous, submucosa and muscular layers. The mucous and muscular layers were clearly separated by a loose submucosa layer with a honeycomb appearance. The surface of the mucous layer was smooth. In esophageal carcinoma, because of tumor tissue infiltration, the submucosa layer was absent, which indicated destruction of the submucosa. The boundary between normal tissue and tumor was comparatively fuzzy, the three-layer structure of the esophageal wall was indistinct. The surface of the mucous layer was rugose. The technology might be helpful in tumor staging of esophageal carcinoma.

Show MeSH
Related in: MedlinePlus