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Phase-contrast X-ray CT imaging of esophagus and esophageal carcinoma.

Zhang J, Tian D, Lin R, Zhou G, Peng G, Su M - Sci Rep (2014)

Bottom Line: The surface of the mucous layer was smooth.The boundary between normal tissue and tumor was comparatively fuzzy, the three-layer structure of the esophageal wall was indistinct.The surface of the mucous layer was rugose.

View Article: PubMed Central - PubMed

Affiliation: First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People's Republic of China.

ABSTRACT
The electron density resolution is 1000 times higher for synchrotron-radiation phase-contrast CT imaging than conventional X-ray absorption imaging in light elements, with which high-resolution X-ray imaging of biological soft tissue can be achieved. In the present study, we used phase-contrast X-ray CT to investigate human resected esophagus and esophageal carcinoma specimens. This technology revealed the three-layer structure of the esophageal wall-- mucous, submucosa and muscular layers. The mucous and muscular layers were clearly separated by a loose submucosa layer with a honeycomb appearance. The surface of the mucous layer was smooth. In esophageal carcinoma, because of tumor tissue infiltration, the submucosa layer was absent, which indicated destruction of the submucosa. The boundary between normal tissue and tumor was comparatively fuzzy, the three-layer structure of the esophageal wall was indistinct. The surface of the mucous layer was rugose. The technology might be helpful in tumor staging of esophageal carcinoma.

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Related in: MedlinePlus

Gas-barium double contrast X-ray image (A) and CT axial view image (B) of normal esophageal tissue.(A) Mucosa shows many setuliforms high-density shadow (double arrow). (B) CT demonstrates the esophageal wall and the relation with adjacent tissues. tra: trachea; fat: fat tissue; ves: blood vessel; eso: esophageal wall.
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f3: Gas-barium double contrast X-ray image (A) and CT axial view image (B) of normal esophageal tissue.(A) Mucosa shows many setuliforms high-density shadow (double arrow). (B) CT demonstrates the esophageal wall and the relation with adjacent tissues. tra: trachea; fat: fat tissue; ves: blood vessel; eso: esophageal wall.

Mentions: Phase-contrast X-ray CT imaging by synchrotron-radiation broadband monochromatic light clearly depicted normal esophageal wall, including the mucous, submucosa and muscular layers (Figure 2). The mucous and muscular layers were clearly separated by a loose submucosa layer, with a honeycomb appearance. The surface of the mucous layer was smooth. We found many strips of tubular low-density areas in the muscular layer, which were crevices that might be caused by fiber contraction during fixation or open-air drying. For comparison, we show a gas-barium double contrast X-ray image and CT image of normal tissue from the same patient (Figure 3). The gas-barium double contrast X-ray image showed the mucosa, displaying setuliform high-density shadows (caused by the barium sulfate coating on the esophageal mucosa surface), as well as gas filling the esophageal lumen. CT revealed the esophageal wall in relation to adjacent tissues. However, both techniques combined could not discriminate the layers of the esophageal wall.


Phase-contrast X-ray CT imaging of esophagus and esophageal carcinoma.

Zhang J, Tian D, Lin R, Zhou G, Peng G, Su M - Sci Rep (2014)

Gas-barium double contrast X-ray image (A) and CT axial view image (B) of normal esophageal tissue.(A) Mucosa shows many setuliforms high-density shadow (double arrow). (B) CT demonstrates the esophageal wall and the relation with adjacent tissues. tra: trachea; fat: fat tissue; ves: blood vessel; eso: esophageal wall.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061548&req=5

f3: Gas-barium double contrast X-ray image (A) and CT axial view image (B) of normal esophageal tissue.(A) Mucosa shows many setuliforms high-density shadow (double arrow). (B) CT demonstrates the esophageal wall and the relation with adjacent tissues. tra: trachea; fat: fat tissue; ves: blood vessel; eso: esophageal wall.
Mentions: Phase-contrast X-ray CT imaging by synchrotron-radiation broadband monochromatic light clearly depicted normal esophageal wall, including the mucous, submucosa and muscular layers (Figure 2). The mucous and muscular layers were clearly separated by a loose submucosa layer, with a honeycomb appearance. The surface of the mucous layer was smooth. We found many strips of tubular low-density areas in the muscular layer, which were crevices that might be caused by fiber contraction during fixation or open-air drying. For comparison, we show a gas-barium double contrast X-ray image and CT image of normal tissue from the same patient (Figure 3). The gas-barium double contrast X-ray image showed the mucosa, displaying setuliform high-density shadows (caused by the barium sulfate coating on the esophageal mucosa surface), as well as gas filling the esophageal lumen. CT revealed the esophageal wall in relation to adjacent tissues. However, both techniques combined could not discriminate the layers of the esophageal wall.

Bottom Line: The surface of the mucous layer was smooth.The boundary between normal tissue and tumor was comparatively fuzzy, the three-layer structure of the esophageal wall was indistinct.The surface of the mucous layer was rugose.

View Article: PubMed Central - PubMed

Affiliation: First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People's Republic of China.

ABSTRACT
The electron density resolution is 1000 times higher for synchrotron-radiation phase-contrast CT imaging than conventional X-ray absorption imaging in light elements, with which high-resolution X-ray imaging of biological soft tissue can be achieved. In the present study, we used phase-contrast X-ray CT to investigate human resected esophagus and esophageal carcinoma specimens. This technology revealed the three-layer structure of the esophageal wall-- mucous, submucosa and muscular layers. The mucous and muscular layers were clearly separated by a loose submucosa layer with a honeycomb appearance. The surface of the mucous layer was smooth. In esophageal carcinoma, because of tumor tissue infiltration, the submucosa layer was absent, which indicated destruction of the submucosa. The boundary between normal tissue and tumor was comparatively fuzzy, the three-layer structure of the esophageal wall was indistinct. The surface of the mucous layer was rugose. The technology might be helpful in tumor staging of esophageal carcinoma.

Show MeSH
Related in: MedlinePlus