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Two patients with new granulomatous lung lesions during treatment of Crohn's disease.

Takeda S, Akagi T, Miyazaki H, Kodama M, Yamamoto S, Beppu T, Nagahama T, Matsui T, Watanabe K, Nagata N - Respir Med Case Rep (2014)

Bottom Line: Video-assisted thoracoscopic surgery (VATS) in June 2012 revealed granulomatous lesions.Tuberculosis, fungal infections, drug-induced lung disorder, and sarcoidosis were ruled out as a cause of the granulomatous lesions in both patients.The aetiology was thought to be CD.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan ; Department of Respiratory Medicine, Fukuoka University Hospital, Japan.

ABSTRACT
Two patients with granulomatous lung lesions thought to be related to Crohn's disease (CD) are reported. Patient 1 was a 43-year-old man who was diagnosed with CD at age 11 years. He developed a fever in the 38 °C, and a chest X-ray and CT scan showed infiltrates with air bronchograms in the right upper lobe and left lingular segment. Transbronchial lung biopsy (TBLB) revealed granulomatous lesions. Patient 2 was a 76-year-old woman who was diagnosed with CD at age 44 years. Chest CT showed infiltrates and nodular shadows in both lung fields. Video-assisted thoracoscopic surgery (VATS) in June 2012 revealed granulomatous lesions. Tuberculosis, fungal infections, drug-induced lung disorder, and sarcoidosis were ruled out as a cause of the granulomatous lesions in both patients. The aetiology was thought to be CD.

No MeSH data available.


Related in: MedlinePlus

Chest X-ray and CT of August 2012. The infiltrative shadow of the right lower and left upper lobes noted in Fig. 4 have improved.
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fig6: Chest X-ray and CT of August 2012. The infiltrative shadow of the right lower and left upper lobes noted in Fig. 4 have improved.

Mentions: These findings were consistent with CD-related pulmonary lesions based on a diagnosis by exclusion and the histopathology. The patient developed dyspnoea on exertion, and treatment with tapering doses of prednisolone (PSL) starting at a dose of 40 mg/day was begun in July 2012. The exertional dyspnoea and imaging findings improved rapidly (Fig. 6).


Two patients with new granulomatous lung lesions during treatment of Crohn's disease.

Takeda S, Akagi T, Miyazaki H, Kodama M, Yamamoto S, Beppu T, Nagahama T, Matsui T, Watanabe K, Nagata N - Respir Med Case Rep (2014)

Chest X-ray and CT of August 2012. The infiltrative shadow of the right lower and left upper lobes noted in Fig. 4 have improved.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061430&req=5

fig6: Chest X-ray and CT of August 2012. The infiltrative shadow of the right lower and left upper lobes noted in Fig. 4 have improved.
Mentions: These findings were consistent with CD-related pulmonary lesions based on a diagnosis by exclusion and the histopathology. The patient developed dyspnoea on exertion, and treatment with tapering doses of prednisolone (PSL) starting at a dose of 40 mg/day was begun in July 2012. The exertional dyspnoea and imaging findings improved rapidly (Fig. 6).

Bottom Line: Video-assisted thoracoscopic surgery (VATS) in June 2012 revealed granulomatous lesions.Tuberculosis, fungal infections, drug-induced lung disorder, and sarcoidosis were ruled out as a cause of the granulomatous lesions in both patients.The aetiology was thought to be CD.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan ; Department of Respiratory Medicine, Fukuoka University Hospital, Japan.

ABSTRACT
Two patients with granulomatous lung lesions thought to be related to Crohn's disease (CD) are reported. Patient 1 was a 43-year-old man who was diagnosed with CD at age 11 years. He developed a fever in the 38 °C, and a chest X-ray and CT scan showed infiltrates with air bronchograms in the right upper lobe and left lingular segment. Transbronchial lung biopsy (TBLB) revealed granulomatous lesions. Patient 2 was a 76-year-old woman who was diagnosed with CD at age 44 years. Chest CT showed infiltrates and nodular shadows in both lung fields. Video-assisted thoracoscopic surgery (VATS) in June 2012 revealed granulomatous lesions. Tuberculosis, fungal infections, drug-induced lung disorder, and sarcoidosis were ruled out as a cause of the granulomatous lesions in both patients. The aetiology was thought to be CD.

No MeSH data available.


Related in: MedlinePlus