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An unusual cause of an anterior mediastinal mass.

Hassan I, Goolam-Mahomed A - Respir Med Case Rep (2014)

Bottom Line: Mesothelioma is a rare tumour and its radiological growth pattern varies.We report the case of a biopsy proven Malignant Pleural Mesothelioma (MPM) presenting as an anterior mediastinal mass in a platinum miner.The prognosis for this aggressive tumour remains poor, despite combination treatment modalities.

View Article: PubMed Central - PubMed

Affiliation: Intensive Care and Pulmonary Medicine, Dr George Mukhari Academic Hospital and University of Limpopo Medunsa Campus, South Africa.

ABSTRACT
Mesothelioma is a rare tumour and its radiological growth pattern varies. We report the case of a biopsy proven Malignant Pleural Mesothelioma (MPM) presenting as an anterior mediastinal mass in a platinum miner. The prognosis for this aggressive tumour remains poor, despite combination treatment modalities.

No MeSH data available.


Related in: MedlinePlus

Positive epithelial membrane antigen stain.
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fig7: Positive epithelial membrane antigen stain.

Mentions: A 56 year old non-smoker male, with a more than 25 year occupational history of platinum mining, presented with unrelenting chest pain that was neither ischaemic nor pleuritic in nature. He had a history of progressive dyspnoea. Physical examination showed clubbing of the digits, an uncommon finding in MPM. The flow volume loop (spirometery) disclosed a mild obstructive pattern. MPM and asbestosis usually demonstrates a restrictive pattern. The clinical significance of this pattern in this patient is uncertain. On bronchoscopy for airway examination the bronchial lavage retrieval yielded a ferruginised asbestos body [Fig. 2.1]. Following a CT Scan of the chest [Figs. 1.1 and 1.2], the diagnosis was established on an ultrasound-guided core biopsy of the mediastinal mass that stained positive for mesothelial markers, including calretinin [Fig. 2.2], AE1/AE3 cytokeratin [Fig. 2.3]and epithelial membrane antigen[Fig. 2.4]. The patient had a high performance status at the time of diagnosis, and was treated with palliative chemotherapy, opioid analgesics and carbamezapine for neuropathic pain, but succumbed a year later to his disease [Fig. 1.3].


An unusual cause of an anterior mediastinal mass.

Hassan I, Goolam-Mahomed A - Respir Med Case Rep (2014)

Positive epithelial membrane antigen stain.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061419&req=5

fig7: Positive epithelial membrane antigen stain.
Mentions: A 56 year old non-smoker male, with a more than 25 year occupational history of platinum mining, presented with unrelenting chest pain that was neither ischaemic nor pleuritic in nature. He had a history of progressive dyspnoea. Physical examination showed clubbing of the digits, an uncommon finding in MPM. The flow volume loop (spirometery) disclosed a mild obstructive pattern. MPM and asbestosis usually demonstrates a restrictive pattern. The clinical significance of this pattern in this patient is uncertain. On bronchoscopy for airway examination the bronchial lavage retrieval yielded a ferruginised asbestos body [Fig. 2.1]. Following a CT Scan of the chest [Figs. 1.1 and 1.2], the diagnosis was established on an ultrasound-guided core biopsy of the mediastinal mass that stained positive for mesothelial markers, including calretinin [Fig. 2.2], AE1/AE3 cytokeratin [Fig. 2.3]and epithelial membrane antigen[Fig. 2.4]. The patient had a high performance status at the time of diagnosis, and was treated with palliative chemotherapy, opioid analgesics and carbamezapine for neuropathic pain, but succumbed a year later to his disease [Fig. 1.3].

Bottom Line: Mesothelioma is a rare tumour and its radiological growth pattern varies.We report the case of a biopsy proven Malignant Pleural Mesothelioma (MPM) presenting as an anterior mediastinal mass in a platinum miner.The prognosis for this aggressive tumour remains poor, despite combination treatment modalities.

View Article: PubMed Central - PubMed

Affiliation: Intensive Care and Pulmonary Medicine, Dr George Mukhari Academic Hospital and University of Limpopo Medunsa Campus, South Africa.

ABSTRACT
Mesothelioma is a rare tumour and its radiological growth pattern varies. We report the case of a biopsy proven Malignant Pleural Mesothelioma (MPM) presenting as an anterior mediastinal mass in a platinum miner. The prognosis for this aggressive tumour remains poor, despite combination treatment modalities.

No MeSH data available.


Related in: MedlinePlus