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Correlation between sialic acid levels in the synovial fluid and the radiographic severity of knee osteoarthritis.

Cui Z, Liu K, Wang A, Liu S, Wang F, Li J - Exp Ther Med (2014)

Bottom Line: The results demonstrated that knee OA patients exhibited significantly elevated levels of serum SA when compared with the healthy controls, and also significantly elevated levels of SF SA when compared with the knee fracture patients.In addition, OA patients of KL grade 3 had significantly higher SA levels in the SF as compared with patients with KL grade 2 (P<0.01).However, there was no significant correlation identified between serum SA levels and KL grade.

View Article: PubMed Central - PubMed

Affiliation: Rehabilitation College, Capital Medical University, Beijing 100069, P.R. China ; Department of Orthopedics and Rehabilitation, China Rehabilitation Research Center, Beijing Charity Hospital, Beijing 100068, P.R. China.

ABSTRACT
Osteoarthritis (OA) is associated with the presence of inflammation. Sialic acid (SA), an acetylated derivative of neuraminic acid, is reported to be a useful biomarker of inflammation. The aim of the present study was to investigate the correlation between SA levels in the serum and synovial fluid (SF) and radiographic severity in patients with knee OA. A total of 234 patients with knee OA were recruited for the study, as well as 20 patients that had suffered a knee injury or fracture (without knee OA) and 160 healthy controls. Radiological grading of OA in the knee was conducted according to the Kellgren-Lawrence (KL) grading system. SA levels in the serum and SF were measured using Warren's thiobarbituric acid assay. The results demonstrated that knee OA patients exhibited significantly elevated levels of serum SA when compared with the healthy controls, and also significantly elevated levels of SF SA when compared with the knee fracture patients. Higher SA levels in the SF were identified in knee OA patients with KL grade 4 as compared with patients with KL grade 2 or 3. In addition, OA patients of KL grade 3 had significantly higher SA levels in the SF as compared with patients with KL grade 2 (P<0.01). The SA levels in the SF of the knee OA patients positively correlated with the KL grades (r=0.353; P<0.01). However, there was no significant correlation identified between serum SA levels and KL grade. Therefore, SA levels in the SF positively correlated with the radiographic severity of OA, thus, SA levels in the SF may serve as a biomarker for the progression of OA.

No MeSH data available.


Related in: MedlinePlus

SA levels in the (A) serum and (B) SF of knee OA patients. *P<0.05, vs. healthy controls; **P<0.01, vs. knee injury/fracture patients. SF, synovial fluid; SA, sialic acid; OA, osteoarthritis.
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f1-etm-08-01-0255: SA levels in the (A) serum and (B) SF of knee OA patients. *P<0.05, vs. healthy controls; **P<0.01, vs. knee injury/fracture patients. SF, synovial fluid; SA, sialic acid; OA, osteoarthritis.

Mentions: Patients with knee OA exhibited significantly elevated serum SA levels as compared with the healthy controls (Table I; Fig. 1A; P<0.05). In addition, the SA levels in the SF increased significantly when compared with the knee injury or fracture patients without knee OA (Fig. 1B; P<0.01).


Correlation between sialic acid levels in the synovial fluid and the radiographic severity of knee osteoarthritis.

Cui Z, Liu K, Wang A, Liu S, Wang F, Li J - Exp Ther Med (2014)

SA levels in the (A) serum and (B) SF of knee OA patients. *P<0.05, vs. healthy controls; **P<0.01, vs. knee injury/fracture patients. SF, synovial fluid; SA, sialic acid; OA, osteoarthritis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061225&req=5

f1-etm-08-01-0255: SA levels in the (A) serum and (B) SF of knee OA patients. *P<0.05, vs. healthy controls; **P<0.01, vs. knee injury/fracture patients. SF, synovial fluid; SA, sialic acid; OA, osteoarthritis.
Mentions: Patients with knee OA exhibited significantly elevated serum SA levels as compared with the healthy controls (Table I; Fig. 1A; P<0.05). In addition, the SA levels in the SF increased significantly when compared with the knee injury or fracture patients without knee OA (Fig. 1B; P<0.01).

Bottom Line: The results demonstrated that knee OA patients exhibited significantly elevated levels of serum SA when compared with the healthy controls, and also significantly elevated levels of SF SA when compared with the knee fracture patients.In addition, OA patients of KL grade 3 had significantly higher SA levels in the SF as compared with patients with KL grade 2 (P<0.01).However, there was no significant correlation identified between serum SA levels and KL grade.

View Article: PubMed Central - PubMed

Affiliation: Rehabilitation College, Capital Medical University, Beijing 100069, P.R. China ; Department of Orthopedics and Rehabilitation, China Rehabilitation Research Center, Beijing Charity Hospital, Beijing 100068, P.R. China.

ABSTRACT
Osteoarthritis (OA) is associated with the presence of inflammation. Sialic acid (SA), an acetylated derivative of neuraminic acid, is reported to be a useful biomarker of inflammation. The aim of the present study was to investigate the correlation between SA levels in the serum and synovial fluid (SF) and radiographic severity in patients with knee OA. A total of 234 patients with knee OA were recruited for the study, as well as 20 patients that had suffered a knee injury or fracture (without knee OA) and 160 healthy controls. Radiological grading of OA in the knee was conducted according to the Kellgren-Lawrence (KL) grading system. SA levels in the serum and SF were measured using Warren's thiobarbituric acid assay. The results demonstrated that knee OA patients exhibited significantly elevated levels of serum SA when compared with the healthy controls, and also significantly elevated levels of SF SA when compared with the knee fracture patients. Higher SA levels in the SF were identified in knee OA patients with KL grade 4 as compared with patients with KL grade 2 or 3. In addition, OA patients of KL grade 3 had significantly higher SA levels in the SF as compared with patients with KL grade 2 (P<0.01). The SA levels in the SF of the knee OA patients positively correlated with the KL grades (r=0.353; P<0.01). However, there was no significant correlation identified between serum SA levels and KL grade. Therefore, SA levels in the SF positively correlated with the radiographic severity of OA, thus, SA levels in the SF may serve as a biomarker for the progression of OA.

No MeSH data available.


Related in: MedlinePlus