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Chromophobe renal cell carcinoma associated with eosinophilia: A report of three cases.

Wei YB, Yan B, Yin Z, Yang JR - Exp Ther Med (2014)

Bottom Line: Eosinophilia is typically associated with allergic reactions, parasitic infestations, certain forms of vasculitis, the use of certain medications and hematologic malignancies.In addition to eosinophilia associated with gastrointestinal tumors, lung cancer and thyroid carcinoma in solid malignancies, there are a limited number of cases describing peripheral hypereosinophilia in urologic tumors.Eosinophilia following tumor resectioning may indicate a poor prognosis, tumor recurrence and rapid disease progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

ABSTRACT
Eosinophilia is typically associated with allergic reactions, parasitic infestations, certain forms of vasculitis, the use of certain medications and hematologic malignancies. In addition to eosinophilia associated with gastrointestinal tumors, lung cancer and thyroid carcinoma in solid malignancies, there are a limited number of cases describing peripheral hypereosinophilia in urologic tumors. The present study reports three cases of eosinophilia in patients with chromophobe renal cell carcinoma (CRCC) and investigates the association between excessive eosinophilia and the recurrence and prognosis of renal carcinoma. This is the first report of CRCC associated with excessive eosinophilia. Eosinophilia following tumor resectioning may indicate a poor prognosis, tumor recurrence and rapid disease progression.

No MeSH data available.


Related in: MedlinePlus

Peripheral blood smear demonstrating eosinophilia.
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f2-etm-08-01-0091: Peripheral blood smear demonstrating eosinophilia.

Mentions: Prior to surgery, routine blood tests revealed that all patients had persistent leukocytosis (11,360–22,230/μl, normal range: 4,000–100,000/μl) and eosinophilia (1,120–5,060/μl, normal range: 0–800/μl; Fig. 2). A routine blood test was administered during the perioperative period and at the one-year follow-up following discharge. Eosinophilia disappeared in the first month following radical nephrectomy. The two male patients presented with normal eosinophilic granulocytes without tumor recurrence following surgery and at the one-year follow-up. However, blood analysis of the female patient revealed that the leukocyte and eosinophilic granulocyte counts had gradually increased and returned to the preoperative levels (Fig. 3). Ultrasound examination revealed renal carcinoma recurrence in the original renal region involving the abdominal wall and intestine. Blood tests demonstrated that the levels of eosinophilic granulocytes continuously increased (19.61–20.49%, normal range: 0–5%). The patient suffered from pain, fever and an abdominal mass. The female patient succumbed to the disease six months following surgery due to tumor recurrence.


Chromophobe renal cell carcinoma associated with eosinophilia: A report of three cases.

Wei YB, Yan B, Yin Z, Yang JR - Exp Ther Med (2014)

Peripheral blood smear demonstrating eosinophilia.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061223&req=5

f2-etm-08-01-0091: Peripheral blood smear demonstrating eosinophilia.
Mentions: Prior to surgery, routine blood tests revealed that all patients had persistent leukocytosis (11,360–22,230/μl, normal range: 4,000–100,000/μl) and eosinophilia (1,120–5,060/μl, normal range: 0–800/μl; Fig. 2). A routine blood test was administered during the perioperative period and at the one-year follow-up following discharge. Eosinophilia disappeared in the first month following radical nephrectomy. The two male patients presented with normal eosinophilic granulocytes without tumor recurrence following surgery and at the one-year follow-up. However, blood analysis of the female patient revealed that the leukocyte and eosinophilic granulocyte counts had gradually increased and returned to the preoperative levels (Fig. 3). Ultrasound examination revealed renal carcinoma recurrence in the original renal region involving the abdominal wall and intestine. Blood tests demonstrated that the levels of eosinophilic granulocytes continuously increased (19.61–20.49%, normal range: 0–5%). The patient suffered from pain, fever and an abdominal mass. The female patient succumbed to the disease six months following surgery due to tumor recurrence.

Bottom Line: Eosinophilia is typically associated with allergic reactions, parasitic infestations, certain forms of vasculitis, the use of certain medications and hematologic malignancies.In addition to eosinophilia associated with gastrointestinal tumors, lung cancer and thyroid carcinoma in solid malignancies, there are a limited number of cases describing peripheral hypereosinophilia in urologic tumors.Eosinophilia following tumor resectioning may indicate a poor prognosis, tumor recurrence and rapid disease progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

ABSTRACT
Eosinophilia is typically associated with allergic reactions, parasitic infestations, certain forms of vasculitis, the use of certain medications and hematologic malignancies. In addition to eosinophilia associated with gastrointestinal tumors, lung cancer and thyroid carcinoma in solid malignancies, there are a limited number of cases describing peripheral hypereosinophilia in urologic tumors. The present study reports three cases of eosinophilia in patients with chromophobe renal cell carcinoma (CRCC) and investigates the association between excessive eosinophilia and the recurrence and prognosis of renal carcinoma. This is the first report of CRCC associated with excessive eosinophilia. Eosinophilia following tumor resectioning may indicate a poor prognosis, tumor recurrence and rapid disease progression.

No MeSH data available.


Related in: MedlinePlus