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Possible factors affecting thyroid dysfunction in hepatitis C virus-infected untreated patients.

Mao XR, Zhang LT, Chen H, Xiao P, Zhang YC - Exp Ther Med (2014)

Bottom Line: The results showed the existence of geographical differences in the types of TD present with HCV infection.Therefore, liver dysfunction may be associated with thyroid disease.This study supports the potential of individualized treatment for HCV-infected patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China ; Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R. China.

ABSTRACT
The present study investigated the association of thyroid dysfunction (TD) with the distribution of chronic hepatitis C virus (HCV) infection in untreated patients. A total of 1,012 cases of HCV-infected patients were collected from different regions, of which 209 patients demonstrated a type of TD (chronic thyroiditis complicated with hyperthyroidism, chronic thyroiditis complicated with hypothyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, hyperthyroidism, hypothyroidism or chronic thyroiditis). The results showed the existence of geographical differences in the types of TD present with HCV infection. The female patients had a higher incidence of autoimmune-related TD than the male patients. High levels of HCV RNA expression were most common in all HCV-infected patients, regardless of the presence of TD. High and medium expression levels of HCV RNA were more prevalent in the patients with autoimmune-related TD. Relative analysis of the HCV RNA levels showed that the pathogenesis of TD was not correlated with the HCV RNA expression levels; however, it may have been associated with autoimmunity. The HCV-infected patients with TD were most commonly middle-aged, whereas young adults were the largest group of patients with HCV and normal thyroid function. Among all HCV genotypes, type 1b was the most common HCV genotype and type 2 was the second most common. Types 3 and 6 were scarce in this study population. No associations were identified between HCV genotypes and thyroid disease. The data of liver function showed that HCV-infected patients with TD had a higher liver dysfunction rate compared with that of the patients with normal thyroid function. Therefore, liver dysfunction may be associated with thyroid disease. This study supports the potential of individualized treatment for HCV-infected patients.

No MeSH data available.


Related in: MedlinePlus

Regional distribution of the patients with HCV recruited in this study. Twenty-eight hospitals were divided territorially into North, Northeast, Southwest, South, Central, Northwest and East China. There were 92 HCV-infected patients in North China, 91 in Southwest China, 104 in South China, 224 in Central China, 162 in Northwest China, 252 in East China and 89 in Northeast China. HCV, hepatitis C virus.
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f1-etm-08-01-0133: Regional distribution of the patients with HCV recruited in this study. Twenty-eight hospitals were divided territorially into North, Northeast, Southwest, South, Central, Northwest and East China. There were 92 HCV-infected patients in North China, 91 in Southwest China, 104 in South China, 224 in Central China, 162 in Northwest China, 252 in East China and 89 in Northeast China. HCV, hepatitis C virus.

Mentions: The registration ID for the present study is the ClinicalTrials.gov identifier NCT01293279. A total of 1,012 patients infected with HCV, including 209 patients with a type of TD, were randomly recruited for this study. The patients were treated at 28 hospitals in different regions of China (Table I) and the age, gender and HCV RNA expression were considered. All the patients were free of cirrhosis and HCC, and had not been treated with interferon. The study was approved by the ethics committees of all hospitals at which the patients were recruited. Written informed consent was obtained from each patient. The hospitals were divided territorially into North, Northeast, Southwest, South, Central, Northwest and East China (Fig. 1). Among the 1,012 patients with HCV infection, there were 92 cases in North China, 91 in Southwest China, 104 in South China, 224 in Central China, 162 in Northwest China, 252 in East China and 89 in Northeast China.


Possible factors affecting thyroid dysfunction in hepatitis C virus-infected untreated patients.

Mao XR, Zhang LT, Chen H, Xiao P, Zhang YC - Exp Ther Med (2014)

Regional distribution of the patients with HCV recruited in this study. Twenty-eight hospitals were divided territorially into North, Northeast, Southwest, South, Central, Northwest and East China. There were 92 HCV-infected patients in North China, 91 in Southwest China, 104 in South China, 224 in Central China, 162 in Northwest China, 252 in East China and 89 in Northeast China. HCV, hepatitis C virus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061218&req=5

f1-etm-08-01-0133: Regional distribution of the patients with HCV recruited in this study. Twenty-eight hospitals were divided territorially into North, Northeast, Southwest, South, Central, Northwest and East China. There were 92 HCV-infected patients in North China, 91 in Southwest China, 104 in South China, 224 in Central China, 162 in Northwest China, 252 in East China and 89 in Northeast China. HCV, hepatitis C virus.
Mentions: The registration ID for the present study is the ClinicalTrials.gov identifier NCT01293279. A total of 1,012 patients infected with HCV, including 209 patients with a type of TD, were randomly recruited for this study. The patients were treated at 28 hospitals in different regions of China (Table I) and the age, gender and HCV RNA expression were considered. All the patients were free of cirrhosis and HCC, and had not been treated with interferon. The study was approved by the ethics committees of all hospitals at which the patients were recruited. Written informed consent was obtained from each patient. The hospitals were divided territorially into North, Northeast, Southwest, South, Central, Northwest and East China (Fig. 1). Among the 1,012 patients with HCV infection, there were 92 cases in North China, 91 in Southwest China, 104 in South China, 224 in Central China, 162 in Northwest China, 252 in East China and 89 in Northeast China.

Bottom Line: The results showed the existence of geographical differences in the types of TD present with HCV infection.Therefore, liver dysfunction may be associated with thyroid disease.This study supports the potential of individualized treatment for HCV-infected patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China ; Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R. China.

ABSTRACT
The present study investigated the association of thyroid dysfunction (TD) with the distribution of chronic hepatitis C virus (HCV) infection in untreated patients. A total of 1,012 cases of HCV-infected patients were collected from different regions, of which 209 patients demonstrated a type of TD (chronic thyroiditis complicated with hyperthyroidism, chronic thyroiditis complicated with hypothyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, hyperthyroidism, hypothyroidism or chronic thyroiditis). The results showed the existence of geographical differences in the types of TD present with HCV infection. The female patients had a higher incidence of autoimmune-related TD than the male patients. High levels of HCV RNA expression were most common in all HCV-infected patients, regardless of the presence of TD. High and medium expression levels of HCV RNA were more prevalent in the patients with autoimmune-related TD. Relative analysis of the HCV RNA levels showed that the pathogenesis of TD was not correlated with the HCV RNA expression levels; however, it may have been associated with autoimmunity. The HCV-infected patients with TD were most commonly middle-aged, whereas young adults were the largest group of patients with HCV and normal thyroid function. Among all HCV genotypes, type 1b was the most common HCV genotype and type 2 was the second most common. Types 3 and 6 were scarce in this study population. No associations were identified between HCV genotypes and thyroid disease. The data of liver function showed that HCV-infected patients with TD had a higher liver dysfunction rate compared with that of the patients with normal thyroid function. Therefore, liver dysfunction may be associated with thyroid disease. This study supports the potential of individualized treatment for HCV-infected patients.

No MeSH data available.


Related in: MedlinePlus