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Feasibility and efficacy of a remote real-time wireless ECG monitoring and stimulation system for management of ventricular arrhythmia in rabbits with myocardial infarction.

Zhou ZW, Gou K, Luo ZY, Li W, Zhang WZ, Li YG - Exp Ther Med (2014)

Bottom Line: IECD implantation and MI surgery, as well as qualified remote and bidirectional signal communications between the implanted IECD and extracorporeal system, were successfully achieved in 18 rabbits.Sustained ventricular tachycardia (VT) was induced in five rabbits (5/20, 25%) prior to MI induction and in 12 rabbits (12/16, 75%) following MI induction.Thus, this model of MI may be used to test the efficacy of novel drugs and devices for the management of VAs.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. China.

ABSTRACT
The purpose of this study was to explore the feasibility of continuous remote monitoring, and the induction and termination of malignant ventricular arrhythmias (VAs) by a novel implantable electronic cardiovascular device (IECD) system in rabbits with myocardial infarction (MI). The IECD was implanted and MI was induced by ligation of the left anterior descending coronary artery in 20 adult rabbits. Internet-based remote electrocardiogram (ECG) monitoring and ventricular stimulation were conducted in remote locations with internet access. The voltage amplitudes of the stimulation signals were recorded synchronously by remote and surface ECG. Programmed stimulation with regular stimuli and regular stimuli with an added extra stimulus were performed prior to and following the MI surgery to induce and terminate VAs. IECD implantation and MI surgery, as well as qualified remote and bidirectional signal communications between the implanted IECD and extracorporeal system, were successfully achieved in 18 rabbits. The voltage of the stimulation signals recorded by the remote and surface ECGs showed a good correlation with the stimulation current (remote ECG, r=0.972 and surface ECG, r=0.988; P<0.001). Sustained ventricular tachycardia (VT) was induced in five rabbits (5/20, 25%) prior to MI induction and in 12 rabbits (12/16, 75%) following MI induction. Of the 17 induced VTs, 16 were successfully terminated by remote ventricular stimulation. The novel IECD system provides qualified remote wireless ECG monitoring and possesses the potential to induce and terminate VAs by remote ventricular pacing in this rabbit model of MI. Thus, this model of MI may be used to test the efficacy of novel drugs and devices for the management of VAs.

No MeSH data available.


Related in: MedlinePlus

VT induced and then terminated by the S1S2 pacing program (upper graphs). VT/VF induced and then terminated by the S1S2 pacing program (lower graphs). SR, sinus rhythm; VT, ventricular tachycardia; VF, ventricular fibrillation; S1S2, regular stimuli with an added extra stimulus.
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f6-etm-08-01-0201: VT induced and then terminated by the S1S2 pacing program (upper graphs). VT/VF induced and then terminated by the S1S2 pacing program (lower graphs). SR, sinus rhythm; VT, ventricular tachycardia; VF, ventricular fibrillation; S1S2, regular stimuli with an added extra stimulus.

Mentions: Sixteen rabbits were stimulated remotely by S1S1 and S1S2 to induce VT and then terminate it afterwards. Sustained VT was induced in five rabbits prior to the MI surgery (5/20, 25%) and terminated successfully. Following the MI surgery, sustained VT was induced in 12 rabbits (12/16, 75%), and four of these VTs deteriorated into VF. The induced sustained VTs/VF were terminated successfully in 11 of the 12 rabbits by S1S1 and S1S2 ventricular stimulation and failed in one, which died of induced VT/VF. Three of the induced VFs were also terminated successfully by ventricular stimulation (Fig. 6). Overall, of 17 induced VTs, 16 (94%) were successfully terminated. The system continued to work well with prolonged use, and high-fidelity and stable wireless ECG signaling was observed for three months in the two rabbits used for observing the battery capacities.


Feasibility and efficacy of a remote real-time wireless ECG monitoring and stimulation system for management of ventricular arrhythmia in rabbits with myocardial infarction.

Zhou ZW, Gou K, Luo ZY, Li W, Zhang WZ, Li YG - Exp Ther Med (2014)

VT induced and then terminated by the S1S2 pacing program (upper graphs). VT/VF induced and then terminated by the S1S2 pacing program (lower graphs). SR, sinus rhythm; VT, ventricular tachycardia; VF, ventricular fibrillation; S1S2, regular stimuli with an added extra stimulus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061215&req=5

f6-etm-08-01-0201: VT induced and then terminated by the S1S2 pacing program (upper graphs). VT/VF induced and then terminated by the S1S2 pacing program (lower graphs). SR, sinus rhythm; VT, ventricular tachycardia; VF, ventricular fibrillation; S1S2, regular stimuli with an added extra stimulus.
Mentions: Sixteen rabbits were stimulated remotely by S1S1 and S1S2 to induce VT and then terminate it afterwards. Sustained VT was induced in five rabbits prior to the MI surgery (5/20, 25%) and terminated successfully. Following the MI surgery, sustained VT was induced in 12 rabbits (12/16, 75%), and four of these VTs deteriorated into VF. The induced sustained VTs/VF were terminated successfully in 11 of the 12 rabbits by S1S1 and S1S2 ventricular stimulation and failed in one, which died of induced VT/VF. Three of the induced VFs were also terminated successfully by ventricular stimulation (Fig. 6). Overall, of 17 induced VTs, 16 (94%) were successfully terminated. The system continued to work well with prolonged use, and high-fidelity and stable wireless ECG signaling was observed for three months in the two rabbits used for observing the battery capacities.

Bottom Line: IECD implantation and MI surgery, as well as qualified remote and bidirectional signal communications between the implanted IECD and extracorporeal system, were successfully achieved in 18 rabbits.Sustained ventricular tachycardia (VT) was induced in five rabbits (5/20, 25%) prior to MI induction and in 12 rabbits (12/16, 75%) following MI induction.Thus, this model of MI may be used to test the efficacy of novel drugs and devices for the management of VAs.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. China.

ABSTRACT
The purpose of this study was to explore the feasibility of continuous remote monitoring, and the induction and termination of malignant ventricular arrhythmias (VAs) by a novel implantable electronic cardiovascular device (IECD) system in rabbits with myocardial infarction (MI). The IECD was implanted and MI was induced by ligation of the left anterior descending coronary artery in 20 adult rabbits. Internet-based remote electrocardiogram (ECG) monitoring and ventricular stimulation were conducted in remote locations with internet access. The voltage amplitudes of the stimulation signals were recorded synchronously by remote and surface ECG. Programmed stimulation with regular stimuli and regular stimuli with an added extra stimulus were performed prior to and following the MI surgery to induce and terminate VAs. IECD implantation and MI surgery, as well as qualified remote and bidirectional signal communications between the implanted IECD and extracorporeal system, were successfully achieved in 18 rabbits. The voltage of the stimulation signals recorded by the remote and surface ECGs showed a good correlation with the stimulation current (remote ECG, r=0.972 and surface ECG, r=0.988; P<0.001). Sustained ventricular tachycardia (VT) was induced in five rabbits (5/20, 25%) prior to MI induction and in 12 rabbits (12/16, 75%) following MI induction. Of the 17 induced VTs, 16 were successfully terminated by remote ventricular stimulation. The novel IECD system provides qualified remote wireless ECG monitoring and possesses the potential to induce and terminate VAs by remote ventricular pacing in this rabbit model of MI. Thus, this model of MI may be used to test the efficacy of novel drugs and devices for the management of VAs.

No MeSH data available.


Related in: MedlinePlus