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Feasibility and efficacy of a remote real-time wireless ECG monitoring and stimulation system for management of ventricular arrhythmia in rabbits with myocardial infarction.

Zhou ZW, Gou K, Luo ZY, Li W, Zhang WZ, Li YG - Exp Ther Med (2014)

Bottom Line: IECD implantation and MI surgery, as well as qualified remote and bidirectional signal communications between the implanted IECD and extracorporeal system, were successfully achieved in 18 rabbits.Sustained ventricular tachycardia (VT) was induced in five rabbits (5/20, 25%) prior to MI induction and in 12 rabbits (12/16, 75%) following MI induction.Thus, this model of MI may be used to test the efficacy of novel drugs and devices for the management of VAs.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. China.

ABSTRACT
The purpose of this study was to explore the feasibility of continuous remote monitoring, and the induction and termination of malignant ventricular arrhythmias (VAs) by a novel implantable electronic cardiovascular device (IECD) system in rabbits with myocardial infarction (MI). The IECD was implanted and MI was induced by ligation of the left anterior descending coronary artery in 20 adult rabbits. Internet-based remote electrocardiogram (ECG) monitoring and ventricular stimulation were conducted in remote locations with internet access. The voltage amplitudes of the stimulation signals were recorded synchronously by remote and surface ECG. Programmed stimulation with regular stimuli and regular stimuli with an added extra stimulus were performed prior to and following the MI surgery to induce and terminate VAs. IECD implantation and MI surgery, as well as qualified remote and bidirectional signal communications between the implanted IECD and extracorporeal system, were successfully achieved in 18 rabbits. The voltage of the stimulation signals recorded by the remote and surface ECGs showed a good correlation with the stimulation current (remote ECG, r=0.972 and surface ECG, r=0.988; P<0.001). Sustained ventricular tachycardia (VT) was induced in five rabbits (5/20, 25%) prior to MI induction and in 12 rabbits (12/16, 75%) following MI induction. Of the 17 induced VTs, 16 were successfully terminated by remote ventricular stimulation. The novel IECD system provides qualified remote wireless ECG monitoring and possesses the potential to induce and terminate VAs by remote ventricular pacing in this rabbit model of MI. Thus, this model of MI may be used to test the efficacy of novel drugs and devices for the management of VAs.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram of the implantable electronic cardiovascular device (IECD) implanted in a rabbit and the extracorporeal remote system. 3G, third-generation mobile communications technology.
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f2-etm-08-01-0201: Schematic diagram of the implantable electronic cardiovascular device (IECD) implanted in a rabbit and the extracorporeal remote system. 3G, third-generation mobile communications technology.

Mentions: The IECD system was provided by Genix Biotek Science Technology (Shanghai) Co., Ltd. (Shanghai, China). The IECD consists of one electronic component box, <5 ml in volume and 15 g in weight, two ECG monitoring electrodes and one bipolar stimulation electrode (5076 lead; Medtronic, Inc., Minneapolis, MN, USA; Fig. 1). The extracorporeal system consisted of a signal transmit-receive box which connected with the internet or the third-generation communication system (virtual private network system), and a personal computer with ECG monitoring and electrical stimulation software (Fig. 2). The personal computer was also used as a central workstation in the system. The computer received remote digital signals and converted them into real-time ECG data. The real-time ECG was saved as a compressed ECG signal file with precise time stamps for off-line analysis. When the IECD was implanted, the extracorporeal system also remotely sent out a stimulation signal wirelessly to the IECD to stimulate the heart via a stimulation electrode. Two stimulation modes were designed in this IECD system: The regular stimuli (S1S1), and the regular stimuli with an added extra stimulus (S1S2). The stimulation parameters of this IECD system were as follows: Stimulation current between 0.1 and 5 mA, stimulation time length between 0.5 and 5 msec, and stimulation rate between 1 and 50 Hz. In the S1S2 program, every seventh S1 was followed by one S2, and the stimulation interval was 1–10 sec.


Feasibility and efficacy of a remote real-time wireless ECG monitoring and stimulation system for management of ventricular arrhythmia in rabbits with myocardial infarction.

Zhou ZW, Gou K, Luo ZY, Li W, Zhang WZ, Li YG - Exp Ther Med (2014)

Schematic diagram of the implantable electronic cardiovascular device (IECD) implanted in a rabbit and the extracorporeal remote system. 3G, third-generation mobile communications technology.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061215&req=5

f2-etm-08-01-0201: Schematic diagram of the implantable electronic cardiovascular device (IECD) implanted in a rabbit and the extracorporeal remote system. 3G, third-generation mobile communications technology.
Mentions: The IECD system was provided by Genix Biotek Science Technology (Shanghai) Co., Ltd. (Shanghai, China). The IECD consists of one electronic component box, <5 ml in volume and 15 g in weight, two ECG monitoring electrodes and one bipolar stimulation electrode (5076 lead; Medtronic, Inc., Minneapolis, MN, USA; Fig. 1). The extracorporeal system consisted of a signal transmit-receive box which connected with the internet or the third-generation communication system (virtual private network system), and a personal computer with ECG monitoring and electrical stimulation software (Fig. 2). The personal computer was also used as a central workstation in the system. The computer received remote digital signals and converted them into real-time ECG data. The real-time ECG was saved as a compressed ECG signal file with precise time stamps for off-line analysis. When the IECD was implanted, the extracorporeal system also remotely sent out a stimulation signal wirelessly to the IECD to stimulate the heart via a stimulation electrode. Two stimulation modes were designed in this IECD system: The regular stimuli (S1S1), and the regular stimuli with an added extra stimulus (S1S2). The stimulation parameters of this IECD system were as follows: Stimulation current between 0.1 and 5 mA, stimulation time length between 0.5 and 5 msec, and stimulation rate between 1 and 50 Hz. In the S1S2 program, every seventh S1 was followed by one S2, and the stimulation interval was 1–10 sec.

Bottom Line: IECD implantation and MI surgery, as well as qualified remote and bidirectional signal communications between the implanted IECD and extracorporeal system, were successfully achieved in 18 rabbits.Sustained ventricular tachycardia (VT) was induced in five rabbits (5/20, 25%) prior to MI induction and in 12 rabbits (12/16, 75%) following MI induction.Thus, this model of MI may be used to test the efficacy of novel drugs and devices for the management of VAs.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. China.

ABSTRACT
The purpose of this study was to explore the feasibility of continuous remote monitoring, and the induction and termination of malignant ventricular arrhythmias (VAs) by a novel implantable electronic cardiovascular device (IECD) system in rabbits with myocardial infarction (MI). The IECD was implanted and MI was induced by ligation of the left anterior descending coronary artery in 20 adult rabbits. Internet-based remote electrocardiogram (ECG) monitoring and ventricular stimulation were conducted in remote locations with internet access. The voltage amplitudes of the stimulation signals were recorded synchronously by remote and surface ECG. Programmed stimulation with regular stimuli and regular stimuli with an added extra stimulus were performed prior to and following the MI surgery to induce and terminate VAs. IECD implantation and MI surgery, as well as qualified remote and bidirectional signal communications between the implanted IECD and extracorporeal system, were successfully achieved in 18 rabbits. The voltage of the stimulation signals recorded by the remote and surface ECGs showed a good correlation with the stimulation current (remote ECG, r=0.972 and surface ECG, r=0.988; P<0.001). Sustained ventricular tachycardia (VT) was induced in five rabbits (5/20, 25%) prior to MI induction and in 12 rabbits (12/16, 75%) following MI induction. Of the 17 induced VTs, 16 were successfully terminated by remote ventricular stimulation. The novel IECD system provides qualified remote wireless ECG monitoring and possesses the potential to induce and terminate VAs by remote ventricular pacing in this rabbit model of MI. Thus, this model of MI may be used to test the efficacy of novel drugs and devices for the management of VAs.

No MeSH data available.


Related in: MedlinePlus