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Paraganglioma of the vagina: a case report and review of the literature.

Cai T, Li Y, Jiang Q, Wang D, Huang Y - Onco Targets Ther (2014)

Bottom Line: She was found to have an immobile solid mass in the right side of her vaginal wall.A transient blood pressure increase occurred during the biopsy.After oral administration of antihypertensive drugs, surgery was performed to completely remove the mass.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, China.

ABSTRACT
Vaginal paraganglioma is a rare and unusual tumor occurring in the vaginal wall. It is a solitary primary paraganglioma, especially in atypical sites. Herein, we report an unusual case of a 17-year-old woman who had not experienced vomiting, or hypertension. She was found to have an immobile solid mass in the right side of her vaginal wall. Positron emission tomography/computed tomography scans revealed a well-defined solid ovoid mass adjacent to the bladder and pelvic floor. Tumor markers were within the normal range. A transient blood pressure increase occurred during the biopsy. After oral administration of antihypertensive drugs, surgery was performed to completely remove the mass. Histopathological examination indicated that it was a paraganglioma of the vagina. Repeat computed tomography examination did not reveal any local recurrence or distant metastasis during the 12-month follow-up period.

No MeSH data available.


Related in: MedlinePlus

Surgical specimen of paraganglioma of vagina.
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f1-ott-7-965: Surgical specimen of paraganglioma of vagina.

Mentions: After oral administration of sustained-release metoprolol and nifedipine tablets for 1 week, the woman had vaginal tumorectomy and reconstruction performed, and she had smooth blood pressure throughout the operation. The tumor mass was gray-white and taupe, with a size of 35×30×25 mm (Figure 1). Microscopically, polygon-like oncocytes were spread in nest or cluster forms. Abundant acidophilic granulates within the cytoplasm and round or oval karyons could be clearly identified. The tumor cells were clustered in small nests or irregular trabecular structures demarcated by delicate fibrous stroma and capillaries in the Zellballen pattern. In the tumor stroma, blood sinus, blood capillary, and little fibrous tissue could be found (Figure 2). Synaptophysin, chromogranin A, protein S-100, neuron-specific enolase, cell proliferation-associated antigen Ki67, and vimentin were all positive, while smooth-muscle actin, human melanoma-associated antigen (HMB-45), and cytokeratin were negative in immunohistochemistry assay (Figure 3).


Paraganglioma of the vagina: a case report and review of the literature.

Cai T, Li Y, Jiang Q, Wang D, Huang Y - Onco Targets Ther (2014)

Surgical specimen of paraganglioma of vagina.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061176&req=5

f1-ott-7-965: Surgical specimen of paraganglioma of vagina.
Mentions: After oral administration of sustained-release metoprolol and nifedipine tablets for 1 week, the woman had vaginal tumorectomy and reconstruction performed, and she had smooth blood pressure throughout the operation. The tumor mass was gray-white and taupe, with a size of 35×30×25 mm (Figure 1). Microscopically, polygon-like oncocytes were spread in nest or cluster forms. Abundant acidophilic granulates within the cytoplasm and round or oval karyons could be clearly identified. The tumor cells were clustered in small nests or irregular trabecular structures demarcated by delicate fibrous stroma and capillaries in the Zellballen pattern. In the tumor stroma, blood sinus, blood capillary, and little fibrous tissue could be found (Figure 2). Synaptophysin, chromogranin A, protein S-100, neuron-specific enolase, cell proliferation-associated antigen Ki67, and vimentin were all positive, while smooth-muscle actin, human melanoma-associated antigen (HMB-45), and cytokeratin were negative in immunohistochemistry assay (Figure 3).

Bottom Line: She was found to have an immobile solid mass in the right side of her vaginal wall.A transient blood pressure increase occurred during the biopsy.After oral administration of antihypertensive drugs, surgery was performed to completely remove the mass.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, China.

ABSTRACT
Vaginal paraganglioma is a rare and unusual tumor occurring in the vaginal wall. It is a solitary primary paraganglioma, especially in atypical sites. Herein, we report an unusual case of a 17-year-old woman who had not experienced vomiting, or hypertension. She was found to have an immobile solid mass in the right side of her vaginal wall. Positron emission tomography/computed tomography scans revealed a well-defined solid ovoid mass adjacent to the bladder and pelvic floor. Tumor markers were within the normal range. A transient blood pressure increase occurred during the biopsy. After oral administration of antihypertensive drugs, surgery was performed to completely remove the mass. Histopathological examination indicated that it was a paraganglioma of the vagina. Repeat computed tomography examination did not reveal any local recurrence or distant metastasis during the 12-month follow-up period.

No MeSH data available.


Related in: MedlinePlus