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Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma.

Verma J, Lal S, Van Noorden CJ - Int J Nanomedicine (2014)

Bottom Line: Despite recent advances, survival of GBM patients remains poor.Major challenges in GBM treatment are drug delivery across the blood-brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies.Third, it discusses different methodologies for synthesis of each inorganic agent.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Harvard Medical School, Boston, MA, USA ; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.

ABSTRACT
Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Major challenges in GBM treatment are drug delivery across the blood-brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies. This article reviews recent advances in the application of magnetic nanoparticles (MNPs), gold nanorods (GNRs), and carbon nanotubes (CNTs) for hyperthermia ablation of GBM. First, the article introduces GBM, its current treatment, and hyperthermia as a potential modality for the management of GBM. Second, it introduces MNPs, GNRs, and CNTs as inorganic agents to induce hyperthermia in GBM. Third, it discusses different methodologies for synthesis of each inorganic agent. Finally, it reviews in vitro and in vivo studies in which MNPs, GNRs, and CNTs have been applied for hyperthermia ablation and drug delivery in GBM.

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Mechanism of action of mesoporous silica-coated gold nanorods (A), gold nanorods without coating (B), and mesoporous silica-coated GNRs (C).Notes: The core of GNRs functioned both as an agent that allowed noninvasive imaging as well as a hyperthermic agent while the outer mesoporous silica shell encapsulated a high drug load, thus posing itself as an effective drug carrier. Reproduced from Zhang Z, Wang L, Wang J, et al. Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv Mater. 2012;24(11):1418–1423.104 Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Abbreviations: Au@SiO2, silica-coated gold nanorods; DOX, doxorubicin; GNRs, gold nanorods.
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f7-ijn-9-2863: Mechanism of action of mesoporous silica-coated gold nanorods (A), gold nanorods without coating (B), and mesoporous silica-coated GNRs (C).Notes: The core of GNRs functioned both as an agent that allowed noninvasive imaging as well as a hyperthermic agent while the outer mesoporous silica shell encapsulated a high drug load, thus posing itself as an effective drug carrier. Reproduced from Zhang Z, Wang L, Wang J, et al. Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv Mater. 2012;24(11):1418–1423.104 Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Abbreviations: Au@SiO2, silica-coated gold nanorods; DOX, doxorubicin; GNRs, gold nanorods.

Mentions: Zhang et al evaluated the potential of mesoporous silica-coated GNRs for cancer theranostics in a proof of concept study in human alveolar adenocarcinoma cells.104 The core of GNRs functioned both as an agent that allowed noninvasive imaging as well as a hyperthermic agent while the outer mesoporous silica shell encapsulated a high drug load, thus posing itself as an effective drug carrier (Figure 7).


Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma.

Verma J, Lal S, Van Noorden CJ - Int J Nanomedicine (2014)

Mechanism of action of mesoporous silica-coated gold nanorods (A), gold nanorods without coating (B), and mesoporous silica-coated GNRs (C).Notes: The core of GNRs functioned both as an agent that allowed noninvasive imaging as well as a hyperthermic agent while the outer mesoporous silica shell encapsulated a high drug load, thus posing itself as an effective drug carrier. Reproduced from Zhang Z, Wang L, Wang J, et al. Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv Mater. 2012;24(11):1418–1423.104 Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Abbreviations: Au@SiO2, silica-coated gold nanorods; DOX, doxorubicin; GNRs, gold nanorods.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061173&req=5

f7-ijn-9-2863: Mechanism of action of mesoporous silica-coated gold nanorods (A), gold nanorods without coating (B), and mesoporous silica-coated GNRs (C).Notes: The core of GNRs functioned both as an agent that allowed noninvasive imaging as well as a hyperthermic agent while the outer mesoporous silica shell encapsulated a high drug load, thus posing itself as an effective drug carrier. Reproduced from Zhang Z, Wang L, Wang J, et al. Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv Mater. 2012;24(11):1418–1423.104 Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Abbreviations: Au@SiO2, silica-coated gold nanorods; DOX, doxorubicin; GNRs, gold nanorods.
Mentions: Zhang et al evaluated the potential of mesoporous silica-coated GNRs for cancer theranostics in a proof of concept study in human alveolar adenocarcinoma cells.104 The core of GNRs functioned both as an agent that allowed noninvasive imaging as well as a hyperthermic agent while the outer mesoporous silica shell encapsulated a high drug load, thus posing itself as an effective drug carrier (Figure 7).

Bottom Line: Despite recent advances, survival of GBM patients remains poor.Major challenges in GBM treatment are drug delivery across the blood-brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies.Third, it discusses different methodologies for synthesis of each inorganic agent.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Harvard Medical School, Boston, MA, USA ; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.

ABSTRACT
Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Major challenges in GBM treatment are drug delivery across the blood-brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies. This article reviews recent advances in the application of magnetic nanoparticles (MNPs), gold nanorods (GNRs), and carbon nanotubes (CNTs) for hyperthermia ablation of GBM. First, the article introduces GBM, its current treatment, and hyperthermia as a potential modality for the management of GBM. Second, it introduces MNPs, GNRs, and CNTs as inorganic agents to induce hyperthermia in GBM. Third, it discusses different methodologies for synthesis of each inorganic agent. Finally, it reviews in vitro and in vivo studies in which MNPs, GNRs, and CNTs have been applied for hyperthermia ablation and drug delivery in GBM.

Show MeSH
Related in: MedlinePlus