Limits...
Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma.

Verma J, Lal S, Van Noorden CJ - Int J Nanomedicine (2014)

Bottom Line: Despite recent advances, survival of GBM patients remains poor.Major challenges in GBM treatment are drug delivery across the blood-brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies.Third, it discusses different methodologies for synthesis of each inorganic agent.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Harvard Medical School, Boston, MA, USA ; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.

ABSTRACT
Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Major challenges in GBM treatment are drug delivery across the blood-brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies. This article reviews recent advances in the application of magnetic nanoparticles (MNPs), gold nanorods (GNRs), and carbon nanotubes (CNTs) for hyperthermia ablation of GBM. First, the article introduces GBM, its current treatment, and hyperthermia as a potential modality for the management of GBM. Second, it introduces MNPs, GNRs, and CNTs as inorganic agents to induce hyperthermia in GBM. Third, it discusses different methodologies for synthesis of each inorganic agent. Finally, it reviews in vitro and in vivo studies in which MNPs, GNRs, and CNTs have been applied for hyperthermia ablation and drug delivery in GBM.

Show MeSH

Related in: MedlinePlus

Structural arrangement of carbon in (A) single-walled nanotube and (B) multiwalled nanotube.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4061173&req=5

f4-ijn-9-2863: Structural arrangement of carbon in (A) single-walled nanotube and (B) multiwalled nanotube.

Mentions: Carbon nanotubes (CNTs) were first observed in 1952 by Radushkevich and Lukyanovich, but only in 1991 was a methodology for the synthesis of CNTs described by Iijima using C60 carbon molecules.63,64 CNTs are most commonly synthesized from allotropes of carbon in two different forms, such as single-walled carbon nanotubes (SWNTs) and multi-walled nanotubes (MWNTs). SWNTs consist of a single tube of graphene, and MWNTs consist of several concentric tubes of graphene (Figure 4). Both forms have unique physical and chemical properties that enable their application in anticancer hyperthermia therapy. CNTs generate heat upon infrared irradiation. Another salient feature of CNTs is the possibility to engineer their surface for conjugation with a wide variety of molecules.64


Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma.

Verma J, Lal S, Van Noorden CJ - Int J Nanomedicine (2014)

Structural arrangement of carbon in (A) single-walled nanotube and (B) multiwalled nanotube.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061173&req=5

f4-ijn-9-2863: Structural arrangement of carbon in (A) single-walled nanotube and (B) multiwalled nanotube.
Mentions: Carbon nanotubes (CNTs) were first observed in 1952 by Radushkevich and Lukyanovich, but only in 1991 was a methodology for the synthesis of CNTs described by Iijima using C60 carbon molecules.63,64 CNTs are most commonly synthesized from allotropes of carbon in two different forms, such as single-walled carbon nanotubes (SWNTs) and multi-walled nanotubes (MWNTs). SWNTs consist of a single tube of graphene, and MWNTs consist of several concentric tubes of graphene (Figure 4). Both forms have unique physical and chemical properties that enable their application in anticancer hyperthermia therapy. CNTs generate heat upon infrared irradiation. Another salient feature of CNTs is the possibility to engineer their surface for conjugation with a wide variety of molecules.64

Bottom Line: Despite recent advances, survival of GBM patients remains poor.Major challenges in GBM treatment are drug delivery across the blood-brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies.Third, it discusses different methodologies for synthesis of each inorganic agent.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Harvard Medical School, Boston, MA, USA ; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.

ABSTRACT
Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Major challenges in GBM treatment are drug delivery across the blood-brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies. This article reviews recent advances in the application of magnetic nanoparticles (MNPs), gold nanorods (GNRs), and carbon nanotubes (CNTs) for hyperthermia ablation of GBM. First, the article introduces GBM, its current treatment, and hyperthermia as a potential modality for the management of GBM. Second, it introduces MNPs, GNRs, and CNTs as inorganic agents to induce hyperthermia in GBM. Third, it discusses different methodologies for synthesis of each inorganic agent. Finally, it reviews in vitro and in vivo studies in which MNPs, GNRs, and CNTs have been applied for hyperthermia ablation and drug delivery in GBM.

Show MeSH
Related in: MedlinePlus