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The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy.

Nitta F, Kunikata H, Aizawa N, Omodaka K, Shiga Y, Yasuda M, Nakazawa T - Clin Ophthalmol (2014)

Bottom Line: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04).In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively).IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

ABSTRACT

Background: This study evaluated the effect of intravitreal injection of bevacizumab (IVB) on macular edema associated with diabetic retinopathy (DME) or branch retinal vein occlusion (BRVOME) using laser speckle flowgraphy.

Methods: A comparative interventional study of 25 eyes from 22 patients with macular edema (DME group: 12 eyes; BRVOME group: 13 eyes) who underwent IVB. Mean blur rate (MBR) was measured in the retinal artery, retinal vein, optic nerve head (ONH), and choroid before and after IVB.

Results: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04). In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively). In the DME group, pre-IVB MBR in the ONH was significantly correlated with post-IVB foveal thickness (R= -0.71, P=0.002). There was no such correlation in the BRVOME group in the ONH.

Conclusion: IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME. This suggests that this noninvasive and objective biomarker may be a useful part of pre-IVB evaluations and decision-making in DME.

No MeSH data available.


Related in: MedlinePlus

Representative eye with branch retinal vein occlusion-associated macular edema.Notes: Images from a 65-year-old woman with BRVOME in her left eye. Fundus color photographs (A and D), color LSFG maps (B and E), and axial OCT images at fovea (C and F) are shown. Pre-IVB findings are above (A, B, and C) and findings 1 month after IVB are below (D, E, and F). In the color LSFG maps (B and E), the numbers 1 and 2 indicate the rectangular scanning areas for the retinal artery and vein, respectively; 3 and 4 indicate the circular and square scanning areas for the optic nerve head and choroid, respectively. Pre-IVB MBR was 15.9 in the retinal artery, 35.7 in the retinal vein, 23.5 in the optic nerve head, and 7.2 in the choroid. MBR 1 month after IVB was 14.0 (12.0% decrease) in the retinal artery, 33.4 (6.4% decrease) in the retinal vein, 26.0 (10.6% increase) in the optic nerve head, and 6.2 (13.9% decrease) in the choroid. Decimal best-corrected visual acuity in the right eye was 0.5 before IVB and did not change after 1 month. FT in the right eye was 364 μm before IVB and 264 μm 1 month after IVB.Abbreviations: BRVOME, branch retinal vein occlusion-associated macular edema; FT, foveal thickness; IVB, intravitreal bevacizumab; LSFG, laser speckle flowgraphy; MBR, mean blur rate; OCT, optical coherence tomography.
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f7-opth-8-1119: Representative eye with branch retinal vein occlusion-associated macular edema.Notes: Images from a 65-year-old woman with BRVOME in her left eye. Fundus color photographs (A and D), color LSFG maps (B and E), and axial OCT images at fovea (C and F) are shown. Pre-IVB findings are above (A, B, and C) and findings 1 month after IVB are below (D, E, and F). In the color LSFG maps (B and E), the numbers 1 and 2 indicate the rectangular scanning areas for the retinal artery and vein, respectively; 3 and 4 indicate the circular and square scanning areas for the optic nerve head and choroid, respectively. Pre-IVB MBR was 15.9 in the retinal artery, 35.7 in the retinal vein, 23.5 in the optic nerve head, and 7.2 in the choroid. MBR 1 month after IVB was 14.0 (12.0% decrease) in the retinal artery, 33.4 (6.4% decrease) in the retinal vein, 26.0 (10.6% increase) in the optic nerve head, and 6.2 (13.9% decrease) in the choroid. Decimal best-corrected visual acuity in the right eye was 0.5 before IVB and did not change after 1 month. FT in the right eye was 364 μm before IVB and 264 μm 1 month after IVB.Abbreviations: BRVOME, branch retinal vein occlusion-associated macular edema; FT, foveal thickness; IVB, intravitreal bevacizumab; LSFG, laser speckle flowgraphy; MBR, mean blur rate; OCT, optical coherence tomography.

Mentions: Representative eyes with DME and BRVOME are shown in Figures 6 and 7, respectively.


The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy.

Nitta F, Kunikata H, Aizawa N, Omodaka K, Shiga Y, Yasuda M, Nakazawa T - Clin Ophthalmol (2014)

Representative eye with branch retinal vein occlusion-associated macular edema.Notes: Images from a 65-year-old woman with BRVOME in her left eye. Fundus color photographs (A and D), color LSFG maps (B and E), and axial OCT images at fovea (C and F) are shown. Pre-IVB findings are above (A, B, and C) and findings 1 month after IVB are below (D, E, and F). In the color LSFG maps (B and E), the numbers 1 and 2 indicate the rectangular scanning areas for the retinal artery and vein, respectively; 3 and 4 indicate the circular and square scanning areas for the optic nerve head and choroid, respectively. Pre-IVB MBR was 15.9 in the retinal artery, 35.7 in the retinal vein, 23.5 in the optic nerve head, and 7.2 in the choroid. MBR 1 month after IVB was 14.0 (12.0% decrease) in the retinal artery, 33.4 (6.4% decrease) in the retinal vein, 26.0 (10.6% increase) in the optic nerve head, and 6.2 (13.9% decrease) in the choroid. Decimal best-corrected visual acuity in the right eye was 0.5 before IVB and did not change after 1 month. FT in the right eye was 364 μm before IVB and 264 μm 1 month after IVB.Abbreviations: BRVOME, branch retinal vein occlusion-associated macular edema; FT, foveal thickness; IVB, intravitreal bevacizumab; LSFG, laser speckle flowgraphy; MBR, mean blur rate; OCT, optical coherence tomography.
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Related In: Results  -  Collection

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f7-opth-8-1119: Representative eye with branch retinal vein occlusion-associated macular edema.Notes: Images from a 65-year-old woman with BRVOME in her left eye. Fundus color photographs (A and D), color LSFG maps (B and E), and axial OCT images at fovea (C and F) are shown. Pre-IVB findings are above (A, B, and C) and findings 1 month after IVB are below (D, E, and F). In the color LSFG maps (B and E), the numbers 1 and 2 indicate the rectangular scanning areas for the retinal artery and vein, respectively; 3 and 4 indicate the circular and square scanning areas for the optic nerve head and choroid, respectively. Pre-IVB MBR was 15.9 in the retinal artery, 35.7 in the retinal vein, 23.5 in the optic nerve head, and 7.2 in the choroid. MBR 1 month after IVB was 14.0 (12.0% decrease) in the retinal artery, 33.4 (6.4% decrease) in the retinal vein, 26.0 (10.6% increase) in the optic nerve head, and 6.2 (13.9% decrease) in the choroid. Decimal best-corrected visual acuity in the right eye was 0.5 before IVB and did not change after 1 month. FT in the right eye was 364 μm before IVB and 264 μm 1 month after IVB.Abbreviations: BRVOME, branch retinal vein occlusion-associated macular edema; FT, foveal thickness; IVB, intravitreal bevacizumab; LSFG, laser speckle flowgraphy; MBR, mean blur rate; OCT, optical coherence tomography.
Mentions: Representative eyes with DME and BRVOME are shown in Figures 6 and 7, respectively.

Bottom Line: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04).In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively).IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

ABSTRACT

Background: This study evaluated the effect of intravitreal injection of bevacizumab (IVB) on macular edema associated with diabetic retinopathy (DME) or branch retinal vein occlusion (BRVOME) using laser speckle flowgraphy.

Methods: A comparative interventional study of 25 eyes from 22 patients with macular edema (DME group: 12 eyes; BRVOME group: 13 eyes) who underwent IVB. Mean blur rate (MBR) was measured in the retinal artery, retinal vein, optic nerve head (ONH), and choroid before and after IVB.

Results: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04). In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively). In the DME group, pre-IVB MBR in the ONH was significantly correlated with post-IVB foveal thickness (R= -0.71, P=0.002). There was no such correlation in the BRVOME group in the ONH.

Conclusion: IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME. This suggests that this noninvasive and objective biomarker may be a useful part of pre-IVB evaluations and decision-making in DME.

No MeSH data available.


Related in: MedlinePlus