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The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy.

Nitta F, Kunikata H, Aizawa N, Omodaka K, Shiga Y, Yasuda M, Nakazawa T - Clin Ophthalmol (2014)

Bottom Line: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04).In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively).IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

ABSTRACT

Background: This study evaluated the effect of intravitreal injection of bevacizumab (IVB) on macular edema associated with diabetic retinopathy (DME) or branch retinal vein occlusion (BRVOME) using laser speckle flowgraphy.

Methods: A comparative interventional study of 25 eyes from 22 patients with macular edema (DME group: 12 eyes; BRVOME group: 13 eyes) who underwent IVB. Mean blur rate (MBR) was measured in the retinal artery, retinal vein, optic nerve head (ONH), and choroid before and after IVB.

Results: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04). In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively). In the DME group, pre-IVB MBR in the ONH was significantly correlated with post-IVB foveal thickness (R= -0.71, P=0.002). There was no such correlation in the BRVOME group in the ONH.

Conclusion: IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME. This suggests that this noninvasive and objective biomarker may be a useful part of pre-IVB evaluations and decision-making in DME.

No MeSH data available.


Related in: MedlinePlus

Relationship between foveal thickness and mean blur rate in eyes with branch retinal vein occlusion-associated macular edema.Notes: Pre-IVB MBR was not correlated with pre-IVB FT (P=0.77) (A), nor was post-IVB MBR correlated with post-IVB FT (P=0.13) (B). In addition, pre-IVB MBR was not correlated with post-IVB FT (P=0.32) (C). One MBR sample is represented by one pixel.Abbreviations: FT, foveal thickness; IVB, intravitreal bevacizumab; MBR, mean blur rate.
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f5-opth-8-1119: Relationship between foveal thickness and mean blur rate in eyes with branch retinal vein occlusion-associated macular edema.Notes: Pre-IVB MBR was not correlated with pre-IVB FT (P=0.77) (A), nor was post-IVB MBR correlated with post-IVB FT (P=0.13) (B). In addition, pre-IVB MBR was not correlated with post-IVB FT (P=0.32) (C). One MBR sample is represented by one pixel.Abbreviations: FT, foveal thickness; IVB, intravitreal bevacizumab; MBR, mean blur rate.

Mentions: The relationship between FT and MBR in the ONH of the DME group is shown in Figure 4. Pre-IVB MBR in the ONH was not correlated with pre-IVB FT (P=0.33), but post-IVB MBR in the ONH was correlated with post-IVB FT (R= −0.80, P=0.009). Furthermore, pre-IVB MBR in the ONH was correlated with post-IVB FT (R= −0.71, P=0.002). The relationship between FT and MBR in the ONH of the BRVOME group is shown in Figure 5. There were no equivalent correlations in the ONH of the BRVOME group.


The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy.

Nitta F, Kunikata H, Aizawa N, Omodaka K, Shiga Y, Yasuda M, Nakazawa T - Clin Ophthalmol (2014)

Relationship between foveal thickness and mean blur rate in eyes with branch retinal vein occlusion-associated macular edema.Notes: Pre-IVB MBR was not correlated with pre-IVB FT (P=0.77) (A), nor was post-IVB MBR correlated with post-IVB FT (P=0.13) (B). In addition, pre-IVB MBR was not correlated with post-IVB FT (P=0.32) (C). One MBR sample is represented by one pixel.Abbreviations: FT, foveal thickness; IVB, intravitreal bevacizumab; MBR, mean blur rate.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061168&req=5

f5-opth-8-1119: Relationship between foveal thickness and mean blur rate in eyes with branch retinal vein occlusion-associated macular edema.Notes: Pre-IVB MBR was not correlated with pre-IVB FT (P=0.77) (A), nor was post-IVB MBR correlated with post-IVB FT (P=0.13) (B). In addition, pre-IVB MBR was not correlated with post-IVB FT (P=0.32) (C). One MBR sample is represented by one pixel.Abbreviations: FT, foveal thickness; IVB, intravitreal bevacizumab; MBR, mean blur rate.
Mentions: The relationship between FT and MBR in the ONH of the DME group is shown in Figure 4. Pre-IVB MBR in the ONH was not correlated with pre-IVB FT (P=0.33), but post-IVB MBR in the ONH was correlated with post-IVB FT (R= −0.80, P=0.009). Furthermore, pre-IVB MBR in the ONH was correlated with post-IVB FT (R= −0.71, P=0.002). The relationship between FT and MBR in the ONH of the BRVOME group is shown in Figure 5. There were no equivalent correlations in the ONH of the BRVOME group.

Bottom Line: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04).In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively).IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

ABSTRACT

Background: This study evaluated the effect of intravitreal injection of bevacizumab (IVB) on macular edema associated with diabetic retinopathy (DME) or branch retinal vein occlusion (BRVOME) using laser speckle flowgraphy.

Methods: A comparative interventional study of 25 eyes from 22 patients with macular edema (DME group: 12 eyes; BRVOME group: 13 eyes) who underwent IVB. Mean blur rate (MBR) was measured in the retinal artery, retinal vein, optic nerve head (ONH), and choroid before and after IVB.

Results: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04). In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively). In the DME group, pre-IVB MBR in the ONH was significantly correlated with post-IVB foveal thickness (R= -0.71, P=0.002). There was no such correlation in the BRVOME group in the ONH.

Conclusion: IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME. This suggests that this noninvasive and objective biomarker may be a useful part of pre-IVB evaluations and decision-making in DME.

No MeSH data available.


Related in: MedlinePlus